Results 71 to 80 of about 104,803 (261)
A Study on Pregnancy with Disseminated Intravascular Coagulation and its Fetomaternal Outcome
National Board of Examinations Journal of Medical SciencesBackground: Obstetric bleeding continues to be the leading cause of maternal death worldwide, and the cornerstone of treatment is early detection of the factors that contribute to hemorrhage and early management of the underlying pathological process ...
Kesha Salvi +5 more
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun +10 more
wiley +1 more source
Proceedings of the Japan Academy. Series B, Physical and Biological SciencesThrombomodulin (TM) is an important regulator of intravascular blood coagulation, fibrinolysis, and inflammation. TM inhibits the procoagulant and proinflammatory activities of thrombin and promotes the thrombin-induced activation of protein C (PC) bound
Koji SUZUKI
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Advanced Science, EarlyView.Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg +18 more
wiley +1 more source
Advanced Science, EarlyView.Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao +11 more
wiley +1 more source
Advanced Science, EarlyView.Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak +6 more
wiley +1 more source
Advanced Science, EarlyView.A high‐strength lightweight refractory high‐entropy alloy achieves extraordinary ductility owing to the introduction of coherent chemically gradient ordered nanodomains (CGONs). The CGONs not only serve as effective barriers to dislocation motion (strengthening) but also significantly promote dislocation nucleation and multiplication (ductilizing) upon
Wei Zhang +3 more
wiley +1 more source
Advanced Science, EarlyView.Intrinsic phase toughening transforms a brittle B2 intermetallic into a plastically deformable, load‐bearing phase, while a heterogeneous laminated architecture suppresses strain localization and interface cracking. The synergy between ductile intermetallics and mesoscale heterogeneity establishes a general design strategy for breaking the long ...
Lu Yang +9 more
wiley +1 more source
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Experimental study on Brazilian splitting characteristics of heat damaged hot dry granite
矿业科学学报In the process of geothermal exploitation in dry-hot granite reservoirs, the heat exchange and cooling of the reservoir can cause thermal damage to high-temperature rocks, directly affecting the mechanical properties of the reservoir rocks.
WU Xinghui +4 more
doaj +1 more source