Results 91 to 100 of about 150,124 (289)

A Study on Pregnancy with Disseminated Intravascular Coagulation and its Fetomaternal Outcome

National Board of Examinations Journal of Medical Sciences
Background: Obstetric bleeding continues to be the leading cause of maternal death worldwide, and the cornerstone of treatment is early detection of the factors that contribute to hemorrhage and early management of the underlying pathological process ...
Kesha Salvi, Smruti Vaishnav, Nitin Raithatha, Nipa Modi, Maitri Patel, Rumi Bhattacharyaji   +5 more
doaj   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

Thrombomodulin: A key regulator of intravascular blood coagulation, fibrinolysis, and inflammation, and a treatment for disseminated intravascular coagulation

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
Thrombomodulin (TM) is an important regulator of intravascular blood coagulation, fibrinolysis, and inflammation. TM inhibits the procoagulant and proinflammatory activities of thrombin and promotes the thrombin-induced activation of protein C (PC) bound
Koji SUZUKI
doaj   +1 more source

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Normas Legales del Sector Cultura, Dic. 1980 - Dic. 1985

, 1985
Designan miembros del Consejo de Junta de Clasificación de Películas. Información recopilada del Boletín del Diario El Peruano, Dic. 1980 - Dic. 1985"
RS N° 041-85-COMS/OAJ
core  

Hierarchical Twin Networks Enable Exceptional Strength and Fracture Toughness in Titanium

Advanced Science, EarlyView.
A commercial‐purity titanium with hierarchical ultrafine twin structures delivers an exceptional combination of fracture toughness (KJIc) of 187 MPa·m1/2 and specific yield strength of 140 MPa·cm3·g−1, in which pre‐engineered high‐density twin boundaries stimulate massive and dislocations to blunt crack tip.
Xiao‐Wei Zou, Ting Zhu, En Ma, Wei‐Zhong Han   +3 more
wiley   +1 more source

Catálogo Normas Legales del Sector Cultura, Dic. 1980 - Dic. 1985

, 1985
Designan representantes del Sector Industria y comercio ante Comité Multisectorial de Asentamiento Rural. Documento que forma parte del “Catálogo de normas legales. Una mirada del Sector Cultura desde el Boletín del Diario El Peruano, Dic.
RM N° 344-85-ICTI/DM
core   +1 more source

On anisotropy of indentation induced piling-up by using optical microstrain measurement

, 2012
[[abstract]]Full strain field measurement is used to study indentation-induced plastic patterns around a spherical indenter. An optical strain measurement system incorporates a digital image correlation (DIC) method to determine displacement fields from ...
Shih, M.H., Lu, Y.Y., 童士恒, Kuo, J.C.   +3 more
core  

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source