Inhibition of mammalian RNA polymerase by 5,6-dichlororibofuranosylbenzimidazole (DRB) and DRB triphosphate [PDF]
DRB triphosphate inhibits activity of isolated RNA polymerase B, and, to a lesser extent, that of polymerase A. The same holds true for transcription in isolated nuclei. It does not act as an initiation inhibitor. In all cases, high concentrations of DRB triphosphate are required. Cells do not phosphorylate DRB to a measurable extent.
C, Dreyer, P, Hausen
openaire +2 more sources
5,6‐dichlororibofuranosylbenzimidazole (DRB) is phosphorylated in salivary gland cells of Chironomus tentans [PDF]
Egyházi, Endre, Shugar, David
openaire +2 more sources
Population pharmacokinetic modeling and simulation of maribavir to support dose selection and regulatory approval in adolescents with posttransplant refractory cytomegalovirus. [PDF]
Sun K, Hayes S, Farrell C, Song IH.
europepmc +1 more source
5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) induces apoptosis in breast cancer cells through inhibiting of Mcl-1 expression. [PDF]
Kuo YH +5 more
europepmc +1 more source
Maribavir Pharmacokinetics and Safety in Participants With Moderate Hepatic Impairment: A Phase 1, Open-Label, Single-Dose, Parallel Group Study. [PDF]
Song I, Chen G, Wu J, Ilic K.
europepmc +1 more source
Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing. [PDF]
Chou S +3 more
europepmc +1 more source
Dual Resistance to Maribavir and Ganciclovir in Transplant Recipients. [PDF]
Kleiboeker SB.
europepmc +1 more source
Evaluating valaciclovir, letermovir, and maribavir safety in first-trimester human placental development. [PDF]
Atukorala I +5 more
europepmc +1 more source
Association Between Cytomegalovirus Viremia Clearance and Post-Solid Organ Transplant Mortality in Patients With Refractory Cytomegalovirus Infection: SOLSTICE Post Hoc Analysis. [PDF]
Kamar N +5 more
europepmc +1 more source

