Results 1 to 10 of about 8,043 (217)

An Efficient and Short Route for the Synthesis of Reverse Pyrrole Ribonucleosides

Journal of the Brazilian Chemical Society, 2002
The synthesis of reverse pyrrole ribonucleosides methyl 5-C-(4-acetyl-5-methyl-pyrrol-1-yl)-2,3-O-isopropylidene-5-deoxy- beta-D-ribofuranoside (10), methyl 5-C-(4-ethoxycarbonyl-5-methyl-pyrrol-1-yl)-2,3-O-isopropylidene-5-deoxy- beta-D-ribofuranoside ...
Pereira Letícia O. R., Cunha Anna C., Souza Maria Cecília B. V. de, Ferreira Vitor F.   +3 more
doaj  

Engineering a Bifunctional Fusion Purine/Pyrimidine Nucleoside Phosphorylase for the Production of Nucleoside Analogs

Biomolecules
Nucleoside phosphorylases (NPs) are pivotal enzymes in the salvage pathway, catalyzing the reversible phosphorolysis of nucleosides to produce nucleobases and α-D-ribose 1-phosphate.
Daniel Hormigo, Jon Del Arco, Javier Acosta, Maximilian J. L. J. Fürst, Jesús Fernández-Lucas   +4 more
doaj   +1 more source

Article III: Further Building Blocks [PDF]

, 1998
Ye
Pearson, Graham S.
core  

Silencing disease genes in the laboratory and the clinic

, 2011
Synthetic nucleic acids are commonly used laboratory tools for modulating gene expression and have the potential to be widely used in the clinic. Progress towards nucleic acid drugs, however, has been slow and many challenges remain to be overcome before
Corey, David R., Watts, Jonathan K.
core   +1 more source

Identification of gut microbiome features associated with host metabolic health in a large population-based cohort

Nature Communications
The complex relationship between the gut microbiome and host metabolic health has been an emerging research area. Several recent studies have highlighted the potential effects of the microbiome’s diversity, composition and metabolic production ...
Ayya Keshet, Eran Segal
doaj   +1 more source

Position-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexes [PDF]

, 2017
A series of oligodeoxyribonucleotides and oligoribonucleotides containing single and multiple tricyclo(tc)-nucleosides in various arrangements were prepared and the thermal and thermodynamic transition profiles of duplexes with complementary DNA and RNA ...
Gerber, Anna-Barbara, Ittig, Damian, Leumann, Christian J.   +2 more
core  

Combined metagenomic and metabolomic analyses reveal gut microbiota dysbiosis and metabolic dysfunction in pediatric neurodevelopmental disorders

Frontiers in Immunology
IntroductionNeurodevelopmental disorders (NDDs) are chronic brain diseases linked to innate immune signaling abnormalities, affecting children with complex gut-brain axis etiologies and limited targeted therapies.
Qi Wang, Yuanhao Luo, Chunmei Mao, Xuesong Xiang, Juanjuan Chen   +4 more
doaj   +1 more source

Live-Cell Bioorthogonal Chemical Imaging: Stimulated Raman Scattering Microscopy of Vibrational Probes [PDF]

, 2016
Innovations in light microscopy have tremendously revolutionized the way researchers study biological systems with subcellular resolution. In particular, fluorescence microscopy with the expanding choices of fluorescent probes has provided a ...
Chen, Zhixing, Hu, Fanghao, Min, Wei, Shen, Yihui, Wei, Lu, Zhang, Luyuan   +5 more
core  

Biocatalytic route to C-3?-azido/-hydroxy-C-4?-spiro-oxetanoribonucleosides

, 2015
The lipase, Novozyme®-435, exclusively deacetylates the 5-O-acetyl over 4-C-acetyloxymethyl group of almost identical reactivity in 5-O-acetyl-4-C-acetyloxymethyl-3-azido-3-deoxy-1,2-O-isopropylidene-?-D-ribofuranose that led to the development of first ...
Kumar, Manish, Kumar, Rajesh, Prasad, Ashok K., Sharma, Vivek K.   +3 more
core   +1 more source

Improved Nucleoside (2'-Deoxy)Ribosyltransferases Maximize Enzyme Promiscuity while Maintaining Catalytic Efficiency. [PDF]

ACS Chem Biol
Tang P, Zickuhr GM, Dickson AL, Harding CJ, Devi S, Lebl T, Harrison DJ, da Silva RG, Czekster CM.   +8 more
europepmc   +2 more sources