Results 31 to 40 of about 8,043 (217)

Synthesis of Disaccharide Nucleosides Utilizing the Temporary Protection of the 2′,3′-cis-Diol of Ribonucleosides by a Boronic Ester

Molecules, 2017
Disaccharide nucleosides are an important class of natural compounds that have a variety of biological activities. In this study, we report on the synthesis of disaccharide nucleosides utilizing the temporary protection of the 2′,3′-cis-diol of ...
Hidehisa Someya, Taiki Itoh, Shin Aoki
doaj   +1 more source

Practical Silyl Protection of Ribonucleosides [PDF]

Organic Letters, 2013
Herein we report the site-selective silylation of the ribonucelosides. The method enables a simple and efficient procedure for accessing suitably protected monomers for automated RNA synthesis. Switching to the opposite enantiomer of the catalyst allows for the selective silylation of the 3'-hydroxyl, which could be used in the synthesis of unnatural ...
Thomas P, Blaisdell, Sunggi, Lee, Pinar, Kasaplar, Xixi, Sun, Kian L, Tan   +4 more
openaire   +2 more sources

The taste of ribonucleosides: Novel macronutrients essential for larval growth are sensed by Drosophila gustatory receptor proteins.

PLoS Biology, 2018
Animals employ various types of taste receptors to identify and discriminate between different nutritious food chemicals. These macronutrients are thought to fall into 3 major groups: carbohydrates/sugars, proteins/amino acids, and fats.
Dushyant Mishra, Natasha Thorne, Chika Miyamoto, Christopher Jagge, Hubert Amrein   +4 more
doaj   +1 more source

Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides [PDF]

, 2014
A major challenge in the study of mycobacterial RNA biology is the lack of a comprehensive RNA isolation method that overcomes the unusual cell wall to faithfully yield the full spectrum of non-coding RNA (ncRNA) species.
Chionh, Yok Hian, Dedon, Peter C., DeMott, Michael S., Hia, Fabian, McBee, Megan E., Pang, Yan Ling Joy   +5 more
core   +1 more source

Nucleobase Protection of Deoxyribo‐ and Ribonucleosides [PDF]

Current Protocols in Nucleic Acid Chemistry, 2017
AbstractOligonucleotides carrying a variety of chemical modifications including conjugates are finding increasing applications in therapeutics, diagnostics, functional genomics, proteomics, and as research tools in chemical and molecular biology. The successful synthesis of oligonucleotides primarily depends on the use of appropriately protected ...
Geeta, Meher, Nabin K, Meher, Radhakrishnan P, Iyer   +2 more
openaire   +5 more sources

Characterizing Benzo[a]pyrene Adducts in Transfer RNAs Using Liquid Chromatography Coupled with Tandem Mass Spectrometry (LC-MS/MS)

Biomedicines, 2023
The activated forms of the environmental pollutant benzo[a]pyrene (B[a]P), such as benzo[a]pyrene diol epoxide (BPDE), are known to cause damage to genomic DNA and proteins. However, the impact of BPDE on ribonucleic acid (RNA) remains unclear.
Cassandra Herbert, Corinna L. Ohrnberger, Ella Quinlisk, Balasubrahmanyam Addepalli, Patrick A. Limbach   +4 more
doaj   +1 more source

Determination of total potentially available nucleosides in bovine milk [PDF]

, 2010
Bovine colostrum and milk samples were collected from two herds over the course of the first month post-partum, pooled for each herd by stage of lactation and total potentially available nucleosides were determined.
Gill, Brendon D., Indyk, Harvey E., Manley-Harris, Merilyn   +2 more
core   +2 more sources

A multidimensional platform for the purification of non-coding RNA species [PDF]

, 2013
A renewed interest in non-coding RNA (ncRNA) has led to the discovery of novel RNA species and post-transcriptional ribonucleoside modifications, and an emerging appreciation for the role of ncRNA in RNA epigenetics.
Anderson, Azarani, Barciszewska, Batey, Beier, Bernstein, Brown, Burns, Chan, Chan, Chan, Chee Sheng Ng, Chen Gu, Chia-Hua Ho, Chomczynski, Chomczynski, Chow, Cunningham, Dame, Dame, Dan Su, Dickman, Dominissini, Dong, Dumnoensun Pruksakorn, Duro, Easton, Erin G. Prestwich, Fabian Hia, Fremont, Galasso, Gilar, Gjerde, Hammann, Holden, Hongping Dong, Horie, I. Ramesh Babu, Jahn, Janse, Janse, Jia, Jones, Kato, Kim, Krowczynska, Levin, Li, Likic, Lujambio, Lukavsky, Matera, Megan E. McBee, Miyauchi, Mullineux, Nagele, Nilsen, Noll, Ozsolak, Ozsolak, Parvez, Pei-Yong Shi, Perez-Novo, Peter C. Dedon, Peter Rainer Preiser, Phizicky, Rinn, Rio, Seong, Sharp, Shi, Sylvie Alonso, Uchiyama, Waghmare, Wu, Wu, Wyatt, Xue, Yan Ling Joy Pang, Yok Hian Chionh, Zou   +80 more
core   +4 more sources

tRNA epitranscriptomics and biased codon are linked to proteome expression in [PDF]

, 2018
Among components of the translational machinery, ribonucleoside modifications on tRNAs are emerging as critical regulators of cell physiology and stress response. Here, we demonstrate highly coordinated behavior of the repertoire of tRNA modifications of
Aniweh, Yaw, Babu, Indrakanti Ramesh, Chionh, Yok Hian, Dedon, Peter C, Gu, Chen, Nah, Qianhui, Ng, Chee Sheng, Preiser, Peter R, Sinha, Ameya   +8 more
core   +1 more source

Lethal Mutagenesis of Picornaviruses with N-6-Modified Purine Nucleoside Analogues [PDF]

, 2008
RNA viruses exhibit extraordinarily high mutation rates during genome replication. Nonnatural ribonucleosides that can increase the mutation rate of RNA viruses by acting as ambiguous substrates during replication have been explored as antiviral agents ...
Barr, Eric W., Bollinger, J. Martin, Jr., Brown, Daniel M., Cameron, Craig E., Edathil, Jocelyn P., Galarraga, Jessica E., Graci, Jason D., Harki, Daniel A., Loakes, David, Peterson, Blake R., Smidansky, Eric D., Too, Kathleen   +11 more
core   +4 more sources