Results 31 to 40 of about 5,924 (208)

General and Modular Synthesis of Isomeric 5-Substituted Pyridin-2-yl and 6-Substituted Pyridin-3-yl C-Ribonucleosides Bearing Diverse Alkyl, Aryl, Hetaryl, Amino, Carbamoyl, and Hydroxy Groups

, 2016
A general modular and practical methodology for preparation of diverse 5-substituted pyridin-2-yl and 6-substituted pyridin-3-yl C-ribonucleosides was developed.
Michal Hocek (1365984), Lenka Slavětínská (1845826), Martin Štefko (2162386), Blanka Klepetářová (1398274)   +3 more
core   +6 more sources

Evaluation of the level of 5'-nucleotidase and some biochemical parameters in the sera of beta-thalassemia patients

Tikrit Journal of Pure Science, 2023
One of the hydrolytic enzymes that catalyzes the hydrolysis of 5' -nucleotides into ribonucleosides and phosphate is the 5'nucleotidase, which is found in several organs.
Sameer M. Al-Gorany, Mohammed Rajeh Altutnchi   +1 more
doaj   +1 more source

Regio- and Stereoselective Glycosylation:  Synthesis of 5-Haloimidazole α-Ribonucleosides

, 2016
We describe the synthesis of novel 5-haloimidazole ribonucleosides as precursors of modified cobalamins. A regio- and stereoselective glycosylation of protected ribose with silylated 4(5)-haloimidazoles produces 5-haloimidazole ribonucleosides ...
Xiang Zou (706903), Edward J. Valente (1487989), Kenneth L. Brown (2168224), Tilak Chandra (1586797)   +3 more
core   +2 more sources

Synthesis of New 1,2,3-Triazol-4-yl-quinazoline Nucleoside and Acyclonucleoside Analogues

Molecules, 2014
In this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-quinazoline ribonucleosides or acyclonucleosides by means of 1,3-dipolar cycloaddition between various O or N-alkylated propargyl-quinazoline and 1'-azido-2',3',5'-tri-O ...
Abdelaaziz Ouahrouch, Moha Taourirte, Joachim W. Engels, Soumaya Benjelloun, Hassan B. Lazrek   +4 more
doaj   +1 more source

Synthesis of oligoribonucleotides containing pyrimidine 2 '-O-[(hydroxyalkoxy)methyl]ribonucleosides

, 2006
A simple and efficient method for the preparation of pyrimidine 2'-O-[(2-hydroxyethoxy) methyl]ribonucleosides and 2'-O-[(3-hydroxypropoxy)methyl]ribonucleosides has been developed.
Brilliantov, C., Herdewijn, Piet, Bobkov, G.V., Van Aerschot, Arthur, Mikhailov, S.N., Rozenski, Jef   +5 more
core   +1 more source

Synthesis and Antiviral Evaluation of 5-(4-Aryl-1,3-butadiyn-1-yl)-uridines and Their Phosphoramidate Pronucleotides

Molecules
The emergence of RNA viruses driven by global population growth and international trade highlights the urgent need for effective antiviral agents that can inhibit viral replication.
Evan Saillard, Otmane Bourzikat, Koffi Assa, Vincent Roy, Luigi A. Agrofoglio   +4 more
doaj   +1 more source

The Impact of rAdo and ^OXOdGuo on the Electronic Properties of Clustered DNA Lesions: A Theoretical Approach

Molecules
Ribonucleotides and 7,8-dihydro-8-oxo-2′-deoxyguanosine (OG) are frequently incorporated into genomic DNA as non-canonical moieties; their local co-occurrence can lead to the formation of clustered DNA lesions (CDLs) which may not be susceptible to ...
Boleslaw T. Karwowski
doaj   +1 more source

Synthesis of [5‘-¹³C]Ribonucleosides and 2‘-Deoxy[5‘-¹³C]ribonucleosides

, 2016
The present efficient synthesis of [5‘-13C]ribonucleosides and 2‘-deoxy[5‘-13C]ribonucleosides is characterized by the synthesis of the d-[5-13C]ribose derivative as an intermediate via the Wittig reaction of 4-aldehydo-d-erythrose dialkyl acetals with ...
Takeshi Sekine (2998752), Etsuko Kawashima (2032711), Kaoru Umabe (3031296)   +2 more
core   +1 more source

Preparation of 2′‐O‐[(Triisopropylsilyl)oxy]methyl‐protected Ribonucleosides [PDF]

, 2001
The [(triisopropylsilyl)oxy]methyl (TOM) group is a useful protecting group for the 2′‐OH of ribonucleosides to be used for oligoribonucleotide synthesis by the phosphoramidite method.
Patrick A. Weiss, Weiss, Patrick A., Pitsch, Stefan, Stefan Pitsch, Pitsch S, Weiss PA   +5 more
core   +1 more source

rNMPID: a database for riboNucleoside Mono-Phosphates In DNA

Bioinformatics Advances, 2023
Abstract Motivation Ribonucleoside monophosphates (rNMPs) are the most abundant non-standard nucleotides embedded in genomic DNA. If the presence of rNMP in DNA cannot be controlled, it can lead to genome instability. The actual positive functions of rNMPs in DNA remain mainly unknown.
Jingcheng Yang, Mo Sun, Zihan Ran, Taehwan Yang, Deepali L Kundnani, Francesca Storici, Penghao Xu   +6 more
openaire   +2 more sources