Results 51 to 60 of about 5,924 (208)
The Role of Ferroptosis Induced by Iron Overload in Osteoblast and Osteoclast Function
Cell Biology International, Volume 50, Issue 10, October 2026.ABSTRACT Iron overload disrupts bone homeostasis by suppressing osteoblast survival and mineralization, while promoting osteoclastogenesis. As a programmed cell death driven by iron‐dependent lipid peroxidation and glutathione peroxidase 4 (GPX4) downregulation. This study investigated the role of ferroptosis in bone cells under iron overload. Exposure
Supagarn Sooksawanwit +9 more
wiley +1 more source
BMC Veterinary Research, 2021 Background Thymidine kinase 1 (TK1) catalyzes the initial phosphorylation of thymidine in the salvage pathway synthesis of dTTP, an essential building block of DNA. TK1 is a cytosolic enzyme with its highest level during the S-phase of the cell cycle. In
Liya Wang +4 more
doaj +1 more source
Reproduction in Domestic Animals, Volume 61, Issue S3, October 2026.ABSTRACT Sperm capacitation requires signals from the female reproductive environment, although the molecular mechanisms governing this process remain poorly understood. Estrous sheep serum (ESS) is widely used in in vitro fertilization of small ruminants, contributing to mimic the female reproductive fluids.
Clara Vidal‐Garcia +9 more
wiley +1 more source
Viruses, 2018 Viral RNA-dependent RNA polymerases (RdRps) play a central role not only in viral replication, but also in the genetic evolution of viral RNAs. After binding to an RNA template and selecting 5′-triphosphate ribonucleosides, viral RdRps synthesize an RNA ...
Barbara Selisko +3 more
doaj +1 more source
BMC Molecular and Cell Biology, 2021 Background Thymidine kinase 1 (TK1) plays a key role in the synthesis of deoxythymidine triphosphate (dTTP) and is thus important for DNA replication and cell proliferation.
Liya Wang +5 more
doaj +1 more source
Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier +7 more
wiley +1 more source
, 1996 A series of polyhalogenated benzimidazole ribonucleosides were found to have potent activity against human cytomegalovirus (HCMV) in our laboratory. The lead compound TCRB was found to be more active and less toxic in vitro against HCMV than the two ...
Zhu, Zhijian
core +4 more sources
Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair
The Journal of Clinical Investigation, 2022 Various populations of cells are recruited to the heart after cardiac injury, but little is known about whether cardiomyocytes directly regulate heart repair.
Shen Li +31 more
doaj +1 more source
How Epitranscriptomic Machinery Senses Environmental Cues
Advanced Biology, Volume 10, Issue 9, September 2026.Exogenous exposures, microenvironmental signals, and intracellular metabolic or redox states can alter RNA‐modification machinery through catalytic chemistry, signaling‐dependent PTMs, compartmental redistribution, or changes in abundance and composition.
Shayan Jalali, Ehsan Pashay Ahi
wiley +1 more source
2‘-C-Branched Ribonucleosides. 2. Synthesis of 2‘-C-β-Trifluoromethyl Pyrimidine Ribonucleosides1
, 2016 The first synthesis of 2‘-C-β-trifluoromethyl pyrimidine ribonucleosides is described. 1,2,3,5-Tetra-O-benzoyl-2-C-β-trifluoromethyl-α-d-ribofuranose (3) is prepared from 1,3,5-tri-O-benzoyl-α-d-ribofuranose (1) in three steps and converted to 3,5-di-O ...
Nan-Sheng Li (1316058) +2 more
core +1 more source