Results 51 to 60 of about 4,285 (173)
Molecules, 2013 Synthesis of 5''-phosphate 2'-O-ribosylribonucleosides [Nr(p)] of four common ribonucleosides, and 3'-phosphoramidites of 5''-phosphate 2'-O-ribosyladenosine and 2'-O-ribosylguanosine using the H-phosphonate chemistry is described.
Marcin K. Chmielewski +1 more
doaj +1 more source
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, Volume 13, Issue 37, 3 July 2026.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
Developmental Neurobiology, Volume 86, Issue 3, July 2026.ABSTRACT Rett syndrome is a neurodevelopmental disorder caused by an X‐linked mutation of the MeCP2 gene. Individuals with Rett syndrome, as well as rodent models of this disorder, demonstrate abnormal cortical responses to sound, which impair auditory discrimination ability.
Isabella K. Myers +6 more
wiley +1 more source
A General Method for Selective Tritylation of Primary Hydroxyl Groups in Carbohydrates and Related Compounds [PDF]
Journal of Sciences, Islamic Republic of Iran, 1989 A general and rapid procedure is developed for the selective tritylation of the 'primary OH-function of the four common ribonucleosides, ascorbic acid, and polyhydric compounds.
doaj
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Ribonucleotide reductases (RNRs) are valuable biocatalysts for the biosynthesis of non‐natural deoxyribonucleotide, relevant in fields like medical science and synthetic biology. In this study, we explore the substrate spectrum of two thermostable RNRs and discuss their implications for nucleotide metabolism and biocatalytical applications ...
Lobna Eltoukhy, Christoph Loderer
wiley +1 more source
Advanced Science, Volume 13, Issue 32, 9 June 2026.ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley +1 more source
Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance
Frontiers in Molecular Biosciences, 2017 Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome.
Matthew J. Young
doaj +1 more source
Animal Genetics, Volume 57, Issue 3, June 2026.ABSTRACT The intramuscular fat (IMF) content is an important indicator of meat quality, affecting the sensory properties of meat. IMF is a complex trait with polygenic nature. This research aimed to identify differentially expressed (DE) genes and key transcription factors (TFs) associated with IMF deposition in the liver of two rabbit lines ...
Jesús Valdés‐Hernández +4 more
wiley +1 more source
Chemical and Pharmaceutical Bulletin, 1981 The degradation of nucleobases, ribonucleosides and ribonucleotides with ozone was examined as a model of the action of ozone on nucleic acids. The degradation rates of nucleobases were in the following order : G, T>U>C>A. Nucleosides and nucleotides were degraded in the same order as in the corresponding nucleobases.
ISHIZAKI, KOZO +3 more
openaire +2 more sources
5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease
Biotechnology and Applied Biochemistry, Volume 73, Issue 3, Page 1137-1150, June 2026.ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng +14 more
wiley +1 more source