Results 71 to 80 of about 5,924 (208)
, 2015 To develop oligonucleotides containing new 2′-O-modified ribonucleosides as nucleic acid drugs, we synthesized three types of ribonucleoside derivatives modified at the 2′-hydroxyl group with 2-(methoxycarbonyl)ethyl (MOCE), 2-(N-methylcarbamoyl)ethyl ...
Tetsuya Nagata (437055) +8 more
core +1 more source
A General Method for Selective Tritylation of Primary Hydroxyl Groups in Carbohydrates and Related Compounds [PDF]
Journal of Sciences, Islamic Republic of Iran, 1989 A general and rapid procedure is developed for the selective tritylation of the 'primary OH-function of the four common ribonucleosides, ascorbic acid, and polyhydric compounds.
doaj
A Modular Nucleoside Kinase Cascade for the Synthesis of Ribonucleoside Triphosphates
Biotechnology and Bioengineering, Volume 123, Issue 8, Page 2180-2191, August 2026.Damm et al. report standardized enzymatic cascades for production of all canonical nucleoside triphosphates from the corresponding nucleosides, using kinase‐catalyzed phosphorylation from acetyl phosphate. Reactions afforded ∼ 100 mM product in near‐quantitative conversion.
Oliver T. Damm +3 more
wiley +1 more source
Current Protocols, Volume 6, Issue 8, August 2026.Abstract Solid‐phase RNA synthesis is challenging because the 2'‐hydroxyl requires a protecting group that is stable during chain assembly yet easily removable without degrading the product. Driven by the demand for long RNA therapeutics, we report a synthesis method using 2'‐O‐acetal levulinic ester (ALE) ribonucleoside 3'‐O‐phosphoramidites.
Zidi Lyu, Adam Katolik, Masad J. Damha
wiley +1 more source
Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance
Frontiers in Molecular Biosciences, 2017 Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome.
Matthew J. Young
doaj +1 more source
Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aims Cancer cells undergo adaptation in hostile tumor microenvironments and go through extensive metabolic reprogramming for flourishing. Oncogenic transformation caused by mutations in some metabolic enzymes results in the generation of some metabolic intermediates called onco‐metabolites.
Mst. Mohona Khatun +8 more
wiley +1 more source
Chemical and Pharmaceutical Bulletin, 1981 The degradation of nucleobases, ribonucleosides and ribonucleotides with ozone was examined as a model of the action of ozone on nucleic acids. The degradation rates of nucleobases were in the following order : G, T>U>C>A. Nucleosides and nucleotides were degraded in the same order as in the corresponding nucleobases.
ISHIZAKI, KOZO +3 more
openaire +2 more sources
Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.ABSTRACT Extracellular vesicles (EVs) mediate intercellular communication within the tumour microenvironment by carrying cargoes from paracrine parent cells. EVs have attracted great research interest for their ability to carry nucleic acids into recipient cells and modulate cellular functions.
Gaoge Sun +11 more
wiley +1 more source
An economical synthesis of D- and L-pyrimidine arabinoand ribonucleosides
, 2011 The one-step synthesis of several β-D/L-arabino- and ribonucleosides was performed in good yields under reflux or microwave-assisted fusion method.
Driss Ouzebla +5 more
core +1 more source
Protecting Groups for the Synthesis of Ribonucleic Acids
CHIMIA, 2001 Methods for the regioselective introduction of alkoxymethyl-groups into the 2?-O-position of 5?-O-dimethoxytritylated, nucleobase-protected ribonucleosides and for the N-alkyloxycarbonylation of adenine and guanine nucleosides were developed ...
Stefan Pitsch
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