Results 91 to 100 of about 8,043 (217)
Microbial Biotechnology, Volume 19, Issue 4, April 2026.The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance
Frontiers in Molecular Biosciences, 2017 Nucleoside reverse transcriptase inhibitors (NRTIs) were the first drugs used to treat human immunodeficiency virus (HIV) the cause of acquired immunodeficiency syndrome.
Matthew J. Young
doaj +1 more source
Characterization of nucleoside transport in the intestinal protozoan parasite Giardia intestinalis. [PDF]
, 1994 A rapid sampling technique has been adapted and used to measure nucleoside transport in a human-derived isolate of the intestinal protozoan parasite Giardia intestinalis (syn. G.
Davey, Robert Andrew
core
A ‘bottom up’, ab initio computational approach to understanding fundamental photophysical processes in nitrogen containing heterocycles, DNA bases and base pairs [PDF]
, 2016 A systematic computational study of non-radiative decay pathways following UV excitation of selected heterocycles, DNA bases, nucleosides and base-pairs in the gas phase.
Ashfold, Michael N R +3 more
core +2 more sources
Clinical and Translational Science, Volume 19, Issue 4, April 2026.ABSTRACT Molnupiravir is an orally administered prodrug of β‐D‐N4‐hydroxycytidine (NHC) that is conditionally approved in China for the treatment of mild to moderate COVID‐19 in nonhospitalized adults at high risk of disease progression. Molnupiravir is rapidly absorbed and hydrolyzed to deliver NHC into systemic circulation.
Jixiang Zhu +10 more
wiley +1 more source
Synthesis and antiviral activity of novel spirocyclic nucleosides [PDF]
, 2018 The synthesis of a number of spirocyclic ribonucleosides containing either a triazolic or azetidinic system is described, along with two analogous phosphonate derivatives of the former.
Abdulsattar, Ban O. +9 more
core +1 more source
Chemical and Pharmaceutical Bulletin, 1970 Adenosine 5'-phosphate was converted to the 2', 3'-cyclic phosphate by the treatment with dimethylformamide at reflux temperature. The reaction was shown to be proceeded by the initial release of the phosphoryl group as an"activated phosphoric acid"and rephosphorylated to furnish the 2', 3'-cyclic phosphate. In fact a ribonucleoside and phosphoric acid,
TOHRU UEDA, IKUKO KAWAI
openaire +2 more sources
The Plant Journal, Volume 126, Issue 2, April 2026.SUMMARY Seeds are resilient to genetic and envirxonmental perturbation. For example, they can compensate for the loss of highly abundant seed storage proteins (SSPs) while maintaining amino acid levels and composition, a process known as proteome rebalancing.
Huda Ansaf +4 more
wiley +1 more source
Protecting Groups for the Synthesis of Ribonucleic Acids
CHIMIA, 2001 Methods for the regioselective introduction of alkoxymethyl-groups into the 2?-O-position of 5?-O-dimethoxytritylated, nucleobase-protected ribonucleosides and for the N-alkyloxycarbonylation of adenine and guanine nucleosides were developed ...
Stefan Pitsch
doaj