Results 101 to 110 of about 5,924 (208)

An Efficient and Short Route for the Synthesis of Reverse Pyrrole Ribonucleosides

Journal of the Brazilian Chemical Society, 2002
The synthesis of reverse pyrrole ribonucleosides methyl 5-C-(4-acetyl-5-methyl-pyrrol-1-yl)-2,3-O-isopropylidene-5-deoxy- beta-D-ribofuranoside (10), methyl 5-C-(4-ethoxycarbonyl-5-methyl-pyrrol-1-yl)-2,3-O-isopropylidene-5-deoxy- beta-D-ribofuranoside ...
Pereira Letícia O. R., Cunha Anna C., Souza Maria Cecília B. V. de, Ferreira Vitor F.   +3 more
doaj  

Identification of gut microbiome features associated with host metabolic health in a large population-based cohort

Nature Communications
The complex relationship between the gut microbiome and host metabolic health has been an emerging research area. Several recent studies have highlighted the potential effects of the microbiome’s diversity, composition and metabolic production ...
Ayya Keshet, Eran Segal
doaj   +1 more source

Engineering a Bifunctional Fusion Purine/Pyrimidine Nucleoside Phosphorylase for the Production of Nucleoside Analogs

Biomolecules
Nucleoside phosphorylases (NPs) are pivotal enzymes in the salvage pathway, catalyzing the reversible phosphorolysis of nucleosides to produce nucleobases and α-D-ribose 1-phosphate.
Daniel Hormigo, Jon Del Arco, Javier Acosta, Maximilian J. L. J. Fürst, Jesús Fernández-Lucas   +4 more
doaj   +1 more source

Spectral libraries from nucleobases and deoxyribonucleosides facilitate the identification of ribonucleosides by nano-flow liquid chromatography–tandem mass spectrometry

Rationale: The study addresses the challenge of identifying RNA post-transcriptional modifications when commercial standards are not available to generate reference spectral libraries. It proposes employing homologous nucleobases and deoxyribonucleosides
Novoa E. M., Tuorto F., Espadas G., Ollivier A., Sabido E., Llovera L.   +5 more
core   +1 more source

Combined metagenomic and metabolomic analyses reveal gut microbiota dysbiosis and metabolic dysfunction in pediatric neurodevelopmental disorders

Frontiers in Immunology
IntroductionNeurodevelopmental disorders (NDDs) are chronic brain diseases linked to innate immune signaling abnormalities, affecting children with complex gut-brain axis etiologies and limited targeted therapies.
Qi Wang, Yuanhao Luo, Chunmei Mao, Xuesong Xiang, Juanjuan Chen   +4 more
doaj   +1 more source

The Refinement and Innovation of The UV Cross-linking and Immunoprecipitation

Shengwu huaxue yu shengwu wuli jinzhan
RNA-binding proteins (RBPs) are ubiquitous components within cells, fulfilling essential functions in a myriad of biological processes. These proteins interact with RNA molecules to regulate gene expression at various levels, including transcription ...
ZHAO Jia-Min, LU Cheng-Jiang, YANG Ming, Nashun Buhe, WANG Gang   +4 more
doaj   +1 more source

The Components of xRNA: Synthesis and Fluorescence of a Full Genetic Set of Size-Expanded Ribonucleosides

, 2016
The synthesis and properties of a full set of four benzo-expanded ribonucleosides (xRNA), analogous to A, G, C, and U RNA monomers, are described. The nucleosides are efficient fluorophores with emission maxima of 369−411 nm.
Eric T. Kool (1310808), Armando R. Hernández (2042572)   +1 more
core   +1 more source

Direct Synthesis of Ribonucleoside 2′,3′-Cyclic Phosphate from Ribonucleoside [PDF]

Agricultural and Biological Chemistry, 1978
Masayoshi Eto, Masayoshi Iio, Hirohisa Omura, Morifusa Eto   +3 more
openaire   +1 more source

Synthesis of heteroaryl substituted pyrazolopyrimidine ribonucleosides with potential biological activity

In this bachelor thesis a series of four heteroaryl substituted pyrazolopyrimidine ribonucleosides was prepared. These nucleosides extend our large series of structurally-active study examining anticancer properties of nucleosides, furthermore the ...
Svobodová, Petra
core  

Synthetic studies to improve the deuterium labelling in nucleosides for facilitating structural studies of large RNAs by high-field NMR spectroscopy

, 2001
Synthetic studies to prepare ribonucleosides deuterated at C2' and the application of the developed procedures for the synthesis of H-2(5)-ribonucleosides from 1,2-O-isopropylidene-3-O-benzyl-ribofuranose-3,4,5,5'-H-2(4) have been reported.
Trifonova, A, Kundu, MK,, Chattopadhyaya, J, Dinya, Z, Foldesi, A   +4 more
core   +1 more source