Results 61 to 70 of about 5,924 (208)

Pentavalent Antimonials: New Perspectives for Old Drugs

Molecules, 2009
Pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate, have been used for more than half a century in the therapy of the parasitic disease leishmaniasis.
Raul R. Ribeiro, Cynthia Demicheli, Frédéric Frézard   +2 more
doaj   +1 more source

METTL14 Regulates Myocardial Infarction Progression via m6A‐Dependent Modulation of OTUD1‐Mediated Deubiquitination of DUSP6

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Myocardial infarction (MI) is the most severe clinical manifestation of coronary artery diseases (CVD) and serves as a critical driver of sudden cardiac death and heart failure (HF). Its pathophysiology begins with the abrupt cessation of coronary blood flow, leading to severe ischemia and subsequent cardiomyocyte necrosis. This study aimed to
Cheng‐Cheng Wei, Ya‐Fang Shen, Jin‐Yu Zhang   +2 more
wiley   +1 more source

Synthesis of 4,6-Disubstituted Pyrimido[4,5-b]indole Ribonucleosides through Regioselective Cross-coupling Reactions

, 2012
A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido[4,5-b]indole ribonucleoside with (
Shi, Pei-Yong, Tichý, Michal, Chen, Yen Liang, Xu, Haoying, Pohl, Radek, Hocek, Michal, Yokokawa, Fumiaki   +6 more
core   +1 more source

Novel Method of Synthesis of 5''-Phosphate 2'-O-ribosyl-ribonucleosides and Their 3'-Phosphoramidites

Molecules, 2013
Synthesis of 5''-phosphate 2'-O-ribosylribonucleosides [Nr(p)] of four common ribonucleosides, and 3'-phosphoramidites of 5''-phosphate 2'-O-ribosyladenosine and 2'-O-ribosylguanosine using the H-phosphonate chemistry is described.
Marcin K. Chmielewski, Wojciech T. Markiewicz   +1 more
doaj   +1 more source

The telomere‐to‐telomere gap‐free reference genome and DNA methylome unveil epigenetic regulation of proanthocyanidin biosynthesis during apricot fruit development

The Plant Journal, Volume 127, Issue 6, September 2026.
SUMMARY Apricot (Prunus armeniaca L.) is an economically significant fruit crop worldwide with remarkable germplasm diversity, and its fruit quality is primarily determined by key metabolites (e.g., sugars, organic acids, and flavonoids). However, current apricot genome assemblies remain incomplete, with substantial unanchored regions that hamper ...
Xu Qiang, Tingting Zhang, Meng Wang, Ting Ren, Guoqing Bai, Ying Zhang, Zhikun Chen, Xiying Du, Yun Jia, Zhonghu Li, Ming Yue   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, Volume 20, Issue 8, Page 2054-2084, August 2026.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Incorporation of Histamine Ribonucleoside into Soluble Proteins [PDF]

Nature, 1966
ISOTOPICALLY labelled histamine ribonucleoside can be detected in the urine of experimental animals after intraperitoneal administration of either 2(ring)−14C-labelled histamine1, or similarly labelled histamine-adenine-dinucleotides2. However, in such experiments the quantities of histamine ribonucleoside recovered from the urine represent only a ...
S G, Alivisatos, F, Ungar, G A, Mourkides   +2 more
openaire   +2 more sources

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, Volume 13, Issue 45, 13 August 2026.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Regioselective 2′‐Silylation of Purine Ribonucleosides for Phosphoramidite RNA Synthesis [PDF]

, 2001
This unit describes high‐yield procedures for protection of purine ribonucleosides based on a reaction that allows concomitant highly regioselective 2′‐silylation and 3′‐phosphitylation to give, in one step, monomers that are ready for H‐phosphonate ...
Roger A. Jones, Gaffney, Barbara L., Barbara L. Gaffney, Jones, Roger A.   +3 more
core   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, Volume 13, Issue 44, 7 August 2026.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source