Results 21 to 30 of about 5,924 (208)
Learning from the Invaders: What Viruses Teach Us about RNA-Based Regulation in Microbes
Microorganisms, 2022 Viruses feature an evolutionary shaped minimal genome that is obligately dependent on the cellular transcription and translation machinery for propagation.
L. Peter Sarin
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Molecules, 2022 An improved protocol for the transformation of ribonucleosides into 2′,3′-dideoxynucleoside and 2′,3′-didehydro-2′,3′-dideoxynucleoside derivatives, including the anti-HIV drugs stavudine (d4T), zalcitabine (ddC) and didanosine (ddI), was established ...
Virginia Martín-Nieves +3 more
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Practical Silyl Protection of Ribonucleosides [PDF]
Organic Letters, 2013 Herein we report the site-selective silylation of the ribonucelosides. The method enables a simple and efficient procedure for accessing suitably protected monomers for automated RNA synthesis. Switching to the opposite enantiomer of the catalyst allows for the selective silylation of the 3'-hydroxyl, which could be used in the synthesis of unnatural ...
Thomas P, Blaisdell +4 more
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Molecules, 2023 Human mitochondrial DNA (mtDNA) is a 16.9 kbp double-stranded, circular DNA, encoding subunits of the oxidative phosphorylation electron transfer chain and essential RNAs for mitochondrial protein translation.
Joon Park +2 more
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Permeability of Coxiella burnetii to ribonucleosides [PDF]
Microbiology, 2002 Knowledge about transport in Coxiella burnetii, an obligate phagolysosomal parasite, is incomplete. The authors investigated the capability of isolated, intact, host-free Coxiella to transport ribonucleosides while incubated at a pH value typical of lysosomes.
Jeffrey D, Miller, Herbert A, Thompson
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Molecules, 2017 Disaccharide nucleosides are an important class of natural compounds that have a variety of biological activities. In this study, we report on the synthesis of disaccharide nucleosides utilizing the temporary protection of the 2′,3′-cis-diol of ...
Hidehisa Someya, Taiki Itoh, Shin Aoki
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Biomedicines, 2023 The activated forms of the environmental pollutant benzo[a]pyrene (B[a]P), such as benzo[a]pyrene diol epoxide (BPDE), are known to cause damage to genomic DNA and proteins. However, the impact of BPDE on ribonucleic acid (RNA) remains unclear.
Cassandra Herbert +4 more
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Synthesis of Novel Bicyclo[2.2.1] Ribonucleosides: 2‘-Amino- and 2‘-Thio-LNA Monomeric Nucleosides
, 2016 Synthesis of Novel Bicyclo[2.2.1] Ribonucleosides: 2‘-Amino- and 2‘-Thio-LNA Monomeric ...
Jesper Wengel (20049) +2 more
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Molecules, 2011 There are more than 100 different ribonucleoside structures incorporated as post-transcriptional modifications, mainly in tRNA and rRNA of both prokaryotes and eukaryotes, and emerging evidence suggests that these modifications function as a system in ...
Peter C. Dedon +8 more
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Biomimetic Ketone Reduction by Disulfide Radical Anion
Molecules, 2021 The conversion of ribonucleosides to 2′-deoxyribonucleosides is catalyzed by ribonucleoside reductase enzymes in nature. One of the key steps in this complex radical mechanism is the reduction of the 3′-ketodeoxynucleotide by a pair of cysteine residues,
Sebastian Barata-Vallejo +5 more
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