Results 21 to 30 of about 8,043 (217)

Ribonucleoside Hydrolases–Structure, Functions, Physiological Role and Practical Uses

Biomolecules, 2023
Ribonucleoside hydrolases are enzymes that catalyze the cleavage of ribonucleosides to nitrogenous bases and ribose. These enzymes are found in many organisms: bacteria, archaea, protozoa, metazoans, yeasts, fungi and plants.
Leonid A. Shaposhnikov, Svyatoslav S. Savin, Vladimir I. Tishkov, Anastasia A. Pometun   +3 more
doaj   +1 more source

Metabolic Analysis of Nucleosides/Bases in the Urine and Serum of Patients with Alcohol-Associated Liver Disease

Metabolites, 2022
Accumulating evidence supports the important role of RNA modifications in liver disease pathogenesis. However, RNA modifications in alcohol-associated liver disease (ALD) have not yet been reported.
Liqing He, Vatsalya Vatsalya, Xipeng Ma, Carolyn M. Klinge, Matthew C. Cave, Wenke Feng, Craig J. McClain, Xiang Zhang   +7 more
doaj   +1 more source

A theoretical perspective of the physical properties of different RNA modifications with respect to RNA duplexes

BBA Advances, 2021
Epitranscriptomic variations include >140 different RNA modifications, many of which can serve as disease biomarkers.Owing to the challenges on synthesizing modified RNA oligos, majority of earlier studies on the effects of RNA modifications to RNA ...
Norman H.L. Chiu, Jennifer H. Simpson, Hongzhou Wang, Bakhos A. Tannous   +3 more
doaj   +1 more source

Learning from the Invaders: What Viruses Teach Us about RNA-Based Regulation in Microbes

Microorganisms, 2022
Viruses feature an evolutionary shaped minimal genome that is obligately dependent on the cellular transcription and translation machinery for propagation.
L. Peter Sarin
doaj   +1 more source

Sustainable Protocol for the Synthesis of 2′,3′-Dideoxynucleoside and 2′,3′-Didehydro-2′,3′-dideoxynucleoside Derivatives

Molecules, 2022
An improved protocol for the transformation of ribonucleosides into 2′,3′-dideoxynucleoside and 2′,3′-didehydro-2′,3′-dideoxynucleoside derivatives, including the anti-HIV drugs stavudine (d4T), zalcitabine (ddC) and didanosine (ddI), was established ...
Virginia Martín-Nieves, Yogesh S. Sanghvi, Susana Fernández, Miguel Ferrero   +3 more
doaj   +1 more source

Phosphorylation of purine and pyrimidine nucleosides by isolated rat liver mitochondria [PDF]

, 1975
Formation of 5'-AMP, 5'-GMP, 5'-CMP and 5'UMP was confirmed in isolated rat liver mitochondria incubated with alpha-ketoglutarate, inorganic phosphate, purine nucleoside and pyrimidine nucleoside. Increased incorporation of 32Pi into ATP, GTP and UTP was
Inaba, Kozo, Oda, Takuzo
core   +1 more source

His+ reversions Caused in Salmonella typhimurium by different types of ionizing radiation [PDF]

, 1988
The yield of his+ reversions in the Ames Salmonella tester strain TA2638 has been determined for 60Co γ rays, 140 kV X rays, 5.4 keV characteristic X rays, 2.2 MeV protons, 3.1 MeV α particles, and 18 MeV/U Fe ions.
Fitzek, M., Kellerer, Albrecht M., Roos, H., Thomas, W.-H.   +3 more
core   +1 more source

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides.

PLoS Pathogens, 2012
Ribonucleoside analogues have potential utility as anti-viral, -parasitic, -bacterial and -cancer agents. However, their clinical applications have been limited by off target effects.
Jamie J Arnold, Suresh D Sharma, Joy Y Feng, Adrian S Ray, Eric D Smidansky, Maria L Kireeva, Aesop Cho, Jason Perry, Jennifer E Vela, Yeojin Park, Yili Xu, Yang Tian, Darius Babusis, Ona Barauskus, Blake R Peterson, Averell Gnatt, Mikhail Kashlev, Weidong Zhong, Craig E Cameron   +18 more
doaj   +1 more source

Structural and Molecular Basis for Mitochondrial DNA Replication and Transcription in Health and Antiviral Drug Toxicity

Molecules, 2023
Human mitochondrial DNA (mtDNA) is a 16.9 kbp double-stranded, circular DNA, encoding subunits of the oxidative phosphorylation electron transfer chain and essential RNAs for mitochondrial protein translation.
Joon Park, Noe Baruch-Torres, Y. Whitney Yin   +2 more
doaj   +1 more source

A System of RNA Modifications and Biased Codon Use Controls Cellular Stress Response at the Level of Translation [PDF]

, 2014
Cells respond to environmental stressors and xenobiotic exposures using regulatory networks to control gene expression, and there is an emerging appreciation for the role of numerous postsynthetic chemical modifications of DNA, RNA, and proteins in ...
Begley, Thomas J., Dedon, Peter C
core   +1 more source