Results 11 to 20 of about 5,924 (208)
Ribonucleosides, Aminoacyl- and Peptidyl-RNA: Synthesis, Thermodynamics, and Structure [PDF]
CHIMIA, 1999 Ribonucleosides, RNA and peptides are prepared to study non-covalent interactions of RNA, aminoacyl- and peptidyl-RNA. Techniques used include chemical synthesis in solution and on solid supports, UV- and NM-detected thermal denaturation, X-ray ...
Ewa Biala +3 more
doaj +2 more sources
The taste of ribonucleosides: Novel macronutrients essential for larval growth are sensed by Drosophila gustatory receptor proteins. [PDF]
PLoS Biology, 2018 Animals employ various types of taste receptors to identify and discriminate between different nutritious food chemicals. These macronutrients are thought to fall into 3 major groups: carbohydrates/sugars, proteins/amino acids, and fats.
Dushyant Mishra +4 more
doaj +2 more sources
Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides. [PDF]
PLoS Pathogens, 2012 Ribonucleoside analogues have potential utility as anti-viral, -parasitic, -bacterial and -cancer agents. However, their clinical applications have been limited by off target effects.
Jamie J Arnold +18 more
doaj +2 more sources
Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC-MS/MS. [PDF]
Biomed ChromatogrABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Deppas JJ +5 more
europepmc +2 more sources
Nucleobase Protection of Deoxyribo‐ and Ribonucleosides [PDF]
Current Protocols in Nucleic Acid Chemistry, 2017 AbstractOligonucleotides carrying a variety of chemical modifications including conjugates are finding increasing applications in therapeutics, diagnostics, functional genomics, proteomics, and as research tools in chemical and molecular biology. The successful synthesis of oligonucleotides primarily depends on the use of appropriately protected ...
Geeta, Meher +2 more
openaire +5 more sources
Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine [PDF]
Biochemical Pharmacology, 1995 6-Methylmercaptopurine ribonucleoside-5'-phosphate (MeSPuRMP), the sole metabolite of 6-methylmercaptopurine ribonucleoside (MeSPuRib), is a strong inhibitor of purine de novo synthesis, inducing depletion of intracellular purine nucleotides and subsequent cell death in several tumor cell lines.
Stet, E.H. +6 more
openaire +5 more sources
Naturally occurring modified ribonucleosides [PDF]
WIREs RNA, 2020 AbstractThe chemical identity of RNA molecules beyond the four standard ribonucleosides has fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in 1951. Since then, the ever‐increasing number and complexity of modified ribonucleosides have been found in viruses and throughout all three domains of life.
Phillip J. McCown +7 more
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Metabolites, 2022 Accumulating evidence supports the important role of RNA modifications in liver disease pathogenesis. However, RNA modifications in alcohol-associated liver disease (ALD) have not yet been reported.
Liqing He +7 more
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BBA Advances, 2021 Epitranscriptomic variations include >140 different RNA modifications, many of which can serve as disease biomarkers.Owing to the challenges on synthesizing modified RNA oligos, majority of earlier studies on the effects of RNA modifications to RNA ...
Norman H.L. Chiu +3 more
doaj +1 more source
ARKIVOC, 2012 International audienceIn this study, we describe the synthesis of 1,4-disustituted-1,2,3-triazolo-ribonucleosides by means of 1,3-dipolar cycloaddition between various N-1 propargyl-pyrimidines and 1'-azido2',3',5'-tri-O-benzoylribose catalyzed by ...
Hanane Elayadi +6 more
doaj +2 more sources