Shock-Induced Degradation of Guanosine and Uridine Promoted by Nickel and Carbonate: Potential Applications [PDF]
Molecules, 2023 Experimental studies of the degradation of two ribonucleosides (guanosine and uridine) were carried out by making use of mechanochemistry. Mechanochemical experiments reveal the decomposition of guanosine and uridine, promoted by nickel(II) and carbonate
Gustavo P. Maia +3 more
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Quantifying the mRNA epitranscriptome reveals epitranscriptome signatures and roles in cancer [PDF]
Cellular and Molecular Life SciencesPost-transcriptional modifications on mRNA are crucial for mRNA fate and function. The current lack of a comprehensive method for high-coverage and sensitive quantitative analysis of mRNA modifications significantly limits the discovery of new mRNA ...
Ying Feng +11 more
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Response of Escherichia coli chemotaxis pathway to pyrimidine deoxyribonucleosides [PDF]
Microbiology SpectrumNucleosides are essential components of all living cells. Bacteria use salvage pathways to import nucleosides from their environment and to utilize them for nucleic acid biosynthesis, but also as alternative sources of carbon, nitrogen and energy. Motile
Malay Shah, Wenhao Xu, Victor Sourjik
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Novel Antimicrobial Activities of Albofungin, Albonoursin, and Ribonucleosides Produced by Streptomyces sp. Caat 5-35 Against Phytopathogens and Their Potential as a Biocontrol Agent [PDF]
MoleculesThe genus Streptomyces is the largest group within the phylum Actinobacteria, recognized for producing antibiotics and enzymes, with wide applications in medicine and biological control for crop protection against phytopathogens.
Carmen Julia Pedroza-Padilla +4 more
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Transcriptional and metabolic stasis define desiccation-induced dormancy in the soil bacterium Arthrobacter sp. AZCC_0090 until water vapor initiates resuscitation [PDF]
mSystemsMicrobes inhabiting soils experience periodic water deprivation. The effects of desiccation on DNA, protein, and membrane integrity are well-described. However, the effects of drying and rehydration on the composition of cellular RNA and metabolites are ...
Paul Carini +13 more
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Toward standardized epitranscriptome analytics: an inter-laboratory comparison of mass spectrometric detection and quantification of modified ribonucleosides in human RNA [PDF]
Nucleic Acids ResearchMartin Hengesbach +2 more
exaly +2 more sources
Frontiers in Molecular Biosciences, 2021 RNA methylation plays a significant regulatory role in various of physiological activities and it has gradually become a hotspot of epigenetics in the past decade.
Zhihao Fang +8 more
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Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine [PDF]
Biochemical Pharmacology, 1995 6-Methylmercaptopurine ribonucleoside-5'-phosphate (MeSPuRMP), the sole metabolite of 6-methylmercaptopurine ribonucleoside (MeSPuRib), is a strong inhibitor of purine de novo synthesis, inducing depletion of intracellular purine nucleotides and subsequent cell death in several tumor cell lines.
Stet, E.H. +6 more
openaire +5 more sources
Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations [PDF]
, 2020 The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Giessmann, Robert T. +9 more
core +1 more source
Photoactivatable ribonucleosides mark base-specific RNA-binding sites
Nature Communications, 2021 RNA-protein interactions play critical roles in post-transcriptional gene regulation. Here the authors demonstrate pRBS-ID, an updated MS/MS-based method that combines the benefits of photoactivatable ribonucleosides and the chemical cleavage of RNA.
Jong Woo Bae +3 more
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