Reusing organic waste materials, such as animal manure, as soil amendments reduces water and fertiliser demand, contributing to achieving the Sustainable Development Goals. However, organic wastes may contain contaminants of emerging concern (CECs), posing potential ecosystem and human health risks. Despite the importance of this issue, there is a lack
Felicity C. T. Elder +7 more
wiley +1 more source
Quantitative sensory testing in painful hand osteoarthritis demonstrates features of peripheral sensitisation. [PDF]
Hand osteoarthritis (HOA) is a prevalent condition for which treatments are based on analgesia and physical therapies. Our primary objective was to evaluate pain perception in participants with HOA by assessing the characteristics of nodal involvement ...
Ejindu, V +5 more
core +2 more sources
Response to commentary article on environmental quality standards for diclofenac derived under the European water framework directive: 1. Aquatic organisms, by Maack et al. 2022 [PDF]
Dean Leverett +3 more
openalex +1 more source
Nanoemulsions for Skin Delivery of Essential Oils: A Systematic Review
ABSTRACT Essential oils (EOs) are recognized for their multiple health benefits. However, their high volatility, low stability, and limited water solubility limit their effective application. This systematic review aims to assess the use of nanoemulsions as delivery systems for the topical administration of EOs, highlighting their efficacy, safety, and
Thais Leticia Moreira da Silva +3 more
wiley +1 more source
ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos +3 more
wiley +1 more source
Noninvasive vagus nerve stimulation as acute therapy for migraine. The randomized PRESTO study [PDF]
Objective: To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for the acute treatment of migraine in a multicenter, double-blind, randomized, sham-controlled ...
Ambrosini, Anna +12 more
core +2 more sources
Novel approaches for drug development against chronic primary pain: A systematic review
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
ADVERSE EFFECTS OF DICLOFENAC SODIUM ON KIDNEYS IN ADULT VOLUNTEERS
Ahmed Othman Hassen Zokari
openalex +2 more sources
Summary Background Tirbanibulin is an approved topical treatment for actinic keratosis (AK). This non‐interventional study investigated effectiveness and safety of tirbanibulin for AK. Patients and Methods The prospective KLIR‐study was conducted at 58 German dermatology centers (02/2022–09/2023).
Markus V. Heppt +4 more
wiley +1 more source
Continuing mortality of vultures in India associated with illegal veterinary use of diclofenac and a potential threat from nimesulide [PDF]
The collapse of South Asia's Gyps vulture populations is attributable to the veterinary use of the non-steroidal anti-inflammatory drug (NSAID) diclofenac. Vultures died after feeding on carcasses of recently-medicated animals.
Cuthbert, RJ +10 more
core +1 more source

