Results 81 to 90 of about 56,639 (202)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Embryonic exposure to diclofenac disturbs actin organization and leads to myofibril misalignment

, 2012
100學年度研究獎補助論文The objective of this study was to investigate the embryotoxicity of diclofenac. Zebrafish (Danio rerio) embryos at 12 hpf were treated with different dosages of diclofenac (0–2,000 ppm) for different time courses (12–72 hr).
Chen, Yau-hung, Chen, Ying-hsin; Chang, Chao-yuan; Wang, Yun-hsin; Wen, Chi-chung; Chen, Yun-chen; Hu, Sheng-chuan; Yu, Dah-shyong; Chen, Yau-hung   +1 more
core   +1 more source

Photochemical and photocatalytic degradation of diclofenac and amoxicillin using natural and simulated sunlight [PDF]

, 2012
Photochemical and titanium dioxide (TiO2) photocatalysed degradations of diclofenac and amoxicillin in water, under natural and simulated sunlight, were investigated.
Kockler, Jutta, Kanakaraju, Devagi, Glass, Beverley, Oelgemöller, Michael   +3 more
core   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Protective effect of chlorogenic acid on diclofenac-induced oxidative stress and inflammation in the liver of BALB/c mice [PDF]

مجله علوم پزشکی فیض (پیوسته)
Background and Aim: Diclofenac, a non-steroidal anti-inflammatory drug, is known to induce liver damage. This study evaluated the protective effects of chlorogenic acid, a plant compound with anti-inflammatory and antioxidant properties, against ...
Mohamad Hadi Yazdani, Firoozeh Saghaei, Maryam Karimi-Dehkordi   +2 more
doaj  

DICLOFENAC: A Review on Its Synthesis, Mechanism of Action, Pharmacokinetics, Prospect and Environmental Impact

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Diclofenac, potent a nonsteroidal anti-inflammatory drug, used in the treatment of inflammation, pain and fever associated with a wide range of disease condition.
Hind A. Satar, Emad Yousif, Ahmed Ahmed   +2 more
doaj   +1 more source

Sensitization profiles in patients with wheat‐dependent exercise‐induced anaphylaxis: practical aspects for allergy workup

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Wheat‐dependent exercise‐induced anaphylaxis (WDEIA) occurs after ingestion of wheat/gluten in the presence of various cofactors. Here, we characterized the sensitization spectrum to various wheat flours, as revealed by skin prick test (SPT) and specific IgE (sIgE) against wheat flour, gluten, and various wheat components.
Enna M. Schwarze, Carolin C. Albers, Randolf Brehler, Mathias Sulk   +3 more
wiley   +1 more source

On the Specific Diclofenac–Iron Cation Interaction for Selective Diclofenac Removal from a Water Solution

Separations
Diclofenac is one of the most common, commercially available, non-steroidal anti-inflammatory drugs (NSAIDs) in the world, with thousands of tons produced and consumed per year, which creates issues related to its presence in water bodies and the need ...
Magdalena Frańska, Aleksandra Grześkowiak   +1 more
doaj   +1 more source

A single‐center prospective observational study evaluating the efficacy and safety of tirbanibulin 1% in actinic keratoses in immunosuppressed patients: the ESTIMATE study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Actinic keratoses (AKs) are common precursors to squamous cell carcinoma and pose a heightened risk in immunosuppressed patients, such as organ transplant recipients (OTRs). Patients and methods This prospective, monocentric, single‐arm observational study investigated the safety and efficacy of topical tirbanibulin 1% ointment in ...
Elisa Zavattaro, Federica Veronese, Vanessa Tarantino, Chiara Airoldi, Paola Savoia   +4 more
wiley   +1 more source