Results 71 to 80 of about 89,653 (252)

Cocrystal construction between the ethyl ester with parent drug of diclofenac: structural, stability, and anti-inflammatory study

Heliyon, 2019
This study aimed to collect the crystallographic data of ethyl diclofenac and discover a cocrystal from this ester with its parent, diclofenac acid, and to investigate their physicochemical properties and anti-inflammation activity.
Ilma Nugrahani, Dwi Utami, Yuda Prasetya Nugraha, Hidehiro Uekusa, Rahel Hasianna, Aisyah Amalia Darusman   +5 more
doaj   +1 more source

Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy [PDF]

, 2017
BACKGROUND. Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments.
Ahu Turkoz, Andras Schaffer, Arturo P. Saavedra, Cipolat, Fenske, Hengameh Mirzaalian, Jean-Pierre Eliane, Lynn A. Cornelius, Mary Tabacchi, Michael Wallendorf, Raphael Kopan, Salasche, Sara Moradi Tuchayi, Seckin, Shadmehr Demehri, Sindhu Manivasagam, Stockfleth, Trevor J. Cunningham, Warino   +18 more
core   +2 more sources

Medication prescription patterns in cancer rehabilitation physiatry outpatients: A multicenter retrospective study

PM&R, EarlyView.
Abstract Background and Objective Previous work from this dataset found 45% prescribing frequency of any medications (35.1%, 33.5%, and 56.8% at institutions 1, 2, and 3 respectively), without significant difference between in‐person and telemedicine.
Matthew Chen, Nafis Eghrari, David Leong, Philip Chang, Jasmine Zheng, Amy Ng, Richard Wilson, Mary Vargo   +7 more
wiley   +1 more source

Effect of iguratimod on diclofenac metabolism by CYP2C9 in rats and human recombinant CYP2C9 yeast cells

Brazilian Journal of Pharmaceutical Sciences
Iguratimod (IGU, also known as T-614), a novel disease modifying antirheumatic drug intended to cure patients with rheumatoid arthritis (RA). The purpose of this study is to evaluate the effect of IGU on the pharmacokinetics of CYP2C9 probe drug ...
Muhammad Usman, Zhu Zhen-Han, Chang Ze-Na, Han Jun-Ping, Qian Wen, Yang Chang-Qing, Nishikawa Miyu, Sakaki Toshiyuki   +7 more
doaj   +1 more source

Effects of diclofenac on the pharmacokinetics of celastrol in rats and its transport

Pharmaceutical Biology, 2018
Context: Diclofenac and celastrol are always used together for the treatment of rheumatoid arthritis; the herb–drug interaction potential between diclofenac and celastrol is still unknown.
Zengfu Wang, Dali Chen, Zhongwei Wang
doaj   +1 more source

Regulated versus unregulated competition: How drug shortages boost illegal pharmacy sales

Strategic Management Journal, EarlyView.
Abstract Research Summary This study examines how product shortages among legal firms create competitive opportunities for illegal firms. We analyze 713 drug shortages in the United States between 2017 and 2023 and show that shortages substantially increase illicit pharmacies’ sales of affected drugs, which rise by 40.5% during shortages and remain 32 ...
Luis Diestre, Benjamin Barber IV
wiley   +1 more source

Importance of the formulation in the skin delivery of topical diclofenac: not all topical diclofenac formulations are the same

Journal of Pain Research, 2019
Julie Pradal, Coralie M Vallet, Guillaume Frappin, Frédérique Bariguian, Maria Stella LombardiDepartment of New Product Development, R&D, GSK Consumer Healthcare S.A, Nyon 1, 1260, SwitzerlandPurpose: The current study aimed to compare ...
Pradal J, Vallet CM, Frappin G, Bariguian F, Lombardi MS   +4 more
doaj  

Salt Cocrystal of Diclofenac Sodium-L-Proline: Structural, Pseudopolymorphism, and Pharmaceutics Performance Study

Pharmaceutics, 2020
Previously, we have reported on a zwitterionic cocrystal of diclofenac acid and L-proline. However, the solubility of this multicomponent crystal was still lower than that of diclofenac sodium salt.
Ilma Nugrahani, Rizka A. Kumalasari, Winni N. Auli, Ayano Horikawa, Hidehiro Uekusa   +4 more
doaj   +1 more source

Effects of various penetration enhancers on percutaneous absorption of piroxicam from emulgels [PDF]

, 2012
A suitable emulgel formulation of piroxicam was prepared and its percutaneous permeation was investigated using Wistar rat skin and diffusion cell technique.
Azarmi, Sh, Fasihi, Z, Hallaj-Nezhadi, S, Javadzadeh, Y, Nokhodchi, A, Shokri, J   +5 more
core   +2 more sources

Clinical utility of ingenol mebutate in the management of actinic keratosis. Perspectives from clinical practice [PDF]

, 2018
Actinic keratoses (AKs) are epidermal cutaneous neoplasia observed predominantly in middle-aged and older subjects with mainly photo type I and photo type II on sun-exposed surfaces as a result of DNA damage.
Bernardini, Nicoletta, Potenza, Concetta, Proietti, Ilaria, Skroza, Nevena   +3 more
core   +1 more source