Results 91 to 100 of about 89,653 (252)

Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes [PDF]

, 2016
Cytochrome p450 (CYP450) enzymes are predominantly involved in Phase I metabolism of xenobiotics. In this study, the CYP450 isoforms involved in xanthotoxol metabolism were identified using recombinant CYP450s.
Cai, Jiqun, Guo, Feng, Ma, Zhongnv, Shan, Lina, Shi, Xianbao, Zhang, Gang   +5 more
core   +5 more sources

Diagnostic Impact of Liver Biopsy Among Antinuclear Antibody Positive Individuals With Mild Liver Enzyme Elevation

Alimentary Pharmacology &Therapeutics, EarlyView.
In ANA‐positive patients with suspected autoimmune hepatitis (AIH), liver biopsy rarely altered therapeutic management when alanine aminotransferase (ALT) was below 101 U/L and cirrhosis was absent. These findings suggest that biopsy may be safely deferred in this low‐risk group.
David Mehdi Asgher Niazi, Alphonse Charbel, Jan Pfeiffenberger, Uta Merle, Jessica Seessle, Theresa Wenz, Christa Flechtenmacher, Patrick Michl, Conrad Rauber   +8 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Layered double hydroxides-indomethacin nanohybrids: intercalation, pH influence, stability and release properties [PDF]

, 2016
In this work, three pH values (8, 9 and 10) were studied for the insertion of Indomethacin (Indo) molecules into Layered Double Hydroxides (LDHs). The obtained results showed that the LDH materials have been a good storage for the drug.
Crivello, Mónica Elsie, Granero, Gladys Ester, Longhi, Marcela Raquel, Mendieta, Silvia Nazaret, Oliva, Marcos Iván, Perez, Celso Francisco, Reyes Nuñez, Patricio   +6 more
core   +1 more source

Long‐term disease control of disseminated superficial actinic porokeratosis (DSAP) with simvastatin 2%/ cholesterol 2% cream

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Introduction Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder associated with an increased risk of cutaneous tumors. Objectives To develop a feasible and easy‐to‐apply treatment regimen for long‐time disease control of DSAP including prevention of new skin tumors. Patients and Methods 19 patients with DSAP
Berenice M. Lang, Gregor Ojak, Mandy Crummenauer, Joanna Wegner, Caroline Mann, Stephan Grabbe, Petra Staubach   +6 more
wiley   +1 more source

Diclofenac-β-cyclodextrin for colonic drug targeting: in vivo performance in rats [PDF]

, 2016
The aim of this in vivo study was to assess the ability of the prodrug conjugate diclofenac-β-cyclodextrin to release diclofenac in the colon following oral administration, using sulfapyridine (a metabolite of sulfasalazine) as a marker of colonic ...
Basit, AW, d’A Rocha Gonsalves, AM, Murdan, S, Serra, AC, Veiga, FJ, Vieira, ACF   +5 more
core   +1 more source

Management of Periodontal Abscesses and Endodontic‐Periodontal Lesions—A Systematic Review

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To evaluate the management of periodontal abscesses and endodontic‐periodontal lesions (EPLs). Methods Seven focused questions addressed outcomes such as pocket depth (PD), bleeding on probing (BOP), tooth loss or ovoid elevation. The literature search covered three electronic databases and manual sources for intervention studies.
Henrik Dommisch, Daniela Hoedke, Marina Dourou, Elena Calciolari, David Herrera, Selena Toma   +5 more
wiley   +1 more source

Quantitative sensory testing in painful hand osteoarthritis demonstrates features of peripheral sensitisation. [PDF]

, 2012
Hand osteoarthritis (HOA) is a prevalent condition for which treatments are based on analgesia and physical therapies. Our primary objective was to evaluate pain perception in participants with HOA by assessing the characteristics of nodal involvement ...
Ejindu, V, Hermansson, M, Heron, C, Kiely, P, Sofat, N, Wajed, J   +5 more
core   +2 more sources

KOH 5% solution versus diclofenac 3% for the treatment of actinic keratosis – Results from a three‐armed RCT

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In this RCT, KOH 5% demonstrated superior clinical success to diclofenac 3% and placebo at the end of treatment in patients with mild‐to‐moderate actinic keratosis and comparable long‐term efficacy to diclofenac. Its fast onset of efficacy and favourable tolerability make KOH a valuable treatment option in early‐stage actinic keratosis treatment ...
U. Reinhold, N. Leitz, R. Dominicus, E. L. Szabó, T. Dirschka, G. Popp, T. C. Fischer, N. Adamini, R. Ostendorf, M. Asefi, H. Durani, T. Hölting, U. Amann, F. Kreuziger, T. Assmann, H. Brüning, L. Freitag, K. Hoffmann, R. Gedschold   +18 more
wiley   +1 more source