Results 91 to 100 of about 35,255 (199)
DDIapp—A Web‐Based Application for Static Drug–Drug Interaction Assessment
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.ABSTRACT In this work we describe the development of a web‐based application for static drug–drug interaction (DDI) risk assessment in accordance with the International Council for Harmonization (ICH) M12 guidance. The app was built using the Shiny for Python framework and it employs a modular mathematical modeling structure that incorporates models ...
Hirotaka Watase +5 more
wiley +1 more source
Environmental Toxicology, Volume 41, Issue 8, Page 507-522, August 2026.ABSTRACT Pesticides and pharmaceuticals are among the most common chemical groups in waterbodies and soils, and their universal distribution raises concerns about potential adverse effects on nontarget organisms and humans. Reproductive output disruption is of particular concern, as it transposes effects from the individual to the next generations at ...
Fábio Campos +3 more
wiley +1 more source
Upper Urinary Tract Stone Disease: Practical Guidance for Early Assessment and Management
Trends in Urology &Men's Health, Volume 17, Issue 4, August 2026.ABSTRACT Upper urinary tract stone disease is a common urological condition with high recurrence rates and a significant healthcare burden. Many patients initially present in community or primary care settings, where early assessment and triage influence patient safety, referral timing and subsequent urological management.
Matthew Kwon, Avi Raman
wiley +1 more source
Exploring Risks of Adverse Drug Events From Single Drug to Three‐Drug Combination
Clinical and Translational Science, Volume 19, Issue 8, August 2026.ABSTRACT Use of three‐drug combinations is common and could increase the risk of adverse drug events (ADEs). Signals of ADEs from three‐drug combinations could be identified from real‐world data, and the risks of ADEs from single drug exposure to three‐drug combination exposure could be illustrated by a graphic model.
Yi Shi +14 more
wiley +1 more source
Effect of turmeric extract on glutathione levels in diclofenac-induced oxidative stress in rats
Acta Biochimica IndonesianaBackground: Glutathione (GSH), the primary endogenous antioxidant, protects cells against oxidative stress. Diclofenac sodium, a commonly prescribed nonsteroidal anti-inflammatory drug (NSAID), depletes GSH through hepatic metabolic byproducts, causing ...
Cynthia Benedikta Jumba +3 more
doaj +1 more source
Journal of Clinical Periodontology, Volume 53, Issue 8, Page 1301-1311, August 2026.ABSTRACT Background Nonsteroidal anti‐inflammatory drugs (NSAIDs) may mitigate periodontal tissue breakdown through cyclooxygenase (COX) inhibition; however, their long‐term effects on the risk of periodontitis remain unclear. Methods We emulated target trials using US electronic health records (1995–2019) to compare the 5‐year risk of incident ...
Ignacio Leiva‐Escobar +7 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 13, 14 July 2026.Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira +8 more
wiley +1 more source
International Journal of Nanomedicine, 2014 Jun Zheng Goh,1 Sook Nai Tang,1 Hoe Siong Chiong,1,2 Yoke Keong Yong,3 Ahmad Zuraini,1 Muhammad Nazrul Hakim1,4 1Department of Biomedical Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; 2InQpharm Group, Kuala Lumpur, Malaysia ...
Goh JZ +5 more
doaj
Evaluation of Hemoadsorption Capacity of the CytoSorb Adsorber for Toxic Doses of Diclofenac and Meloxicam in Porcine Plasma. [PDF]
J Clin ApherGiani B +3 more
europepmc +1 more source