The seminal Michaelis–Menten theorization for biological catalysis was based on “transition state” (TS), involving the formation of a topologically complementary substrate (S) and enzyme (E) complex (ES) at the “active site” of the latter. Rudolph Marcus put forth the theory of outer sphere electron transfer (ET) in a “donor–acceptor” TS complex, which
Kelath Murali Manoj +4 more
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Synthesis, structural elucidation, and molecular docking of diclofenac-derived hydrazone metal complexes with anti-inflammatory and anticancer potential. [PDF]
Abbas AM, Salem HA, Orabi AS.
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Pharmacokinetics, Bioequivalence, and Safety of Diclofenac Sodium Sustained‐Release Tablets in Healthy Chinese Subjects Under Fasting and Fed Conditions [PDF]
Biao Sun +3 more
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Background Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by persistent synovitis, cartilage damage, progressive disability, and a significant decline in quality of life. The advent of biologics and small molecule inhibitors has substantially improved disease management and reduced disability.
Nasser M. Alorfi +8 more
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Chemically tuned radiolabeling and membrane affinity in Drug-Functionalized carbon nanotube nanocarriers. [PDF]
Abdollahi S, Raissi H, Farzad F.
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Intramuscular Drotaverine and Diclofenac in Acute Renal Colic: A Comparative Study of Analgesic Efficacy and Safety [PDF]
Amitabh Dash +3 more
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Health Benefits and Therapeutic Potential of Quercetin
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
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Low dose NSAIDs and sysadoas in the management of knee osteoarthritis. [PDF]
Migliore A +11 more
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Promoting organic nucleation of diclofenac: hydrophobic interfacial interactions drive self-assembly. [PDF]
Lu H +8 more
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