Results 221 to 230 of about 46,100 (277)

Pharmacology of diclofenac sodium

The American Journal of Medicine, 1986
Diclofenac sodium is the active ingredient in Voltaren, a nonsteroidal anti-inflammatory drug designed by selection of appropriate physicochemical and steric properties. Its pharmacologic activity, specifically its effects in acute and subchronic inflammation, and its analgesic activity have been assessed in animal models.
D W, Scholer, E C, Ku, I, Boettcher, A, Schweizer   +3 more
openaire   +2 more sources

Pharmacology of diclofenac sodium (Voltaren®)

Seminars in Arthritis and Rheumatism, 1985
HE treatment of inflammatory conditions and rheumatic disorders is largely based on the use of nonsteroidal, anti-inflammatory agents. The choice of the appropriate drug, among a considerable number of compounds, depends ultimately on therapeutic efficacy and tolerability/safety profiles as observed under clinical conditions.
D W, Scholer, I, Boettcher, E C, Ku, A, Schweizer   +3 more
openaire   +2 more sources

Nanostructured Diclofenac Sodium Releasing Material

AIP Conference Proceedings, 2008
Various techniques have been developed to produce second generation biomaterials for tissue repair. These include extrusion, molding, salt leaching, spinning etc, but success in regenerating tissues has been limited. It is important to develop porous material, yet with a fibrous structure for it to be biomimetic.
L. Nikkola, K. Vapalahti, A. Harlin, J. Seppälä, N. Ashammakhi, Glaucio H. Paulino, Marek-Jerzy Pindera, Robert H. Dodds, Fernando A. Rochinha, Eshan Dave, Linfeng Chen   +10 more
openaire   +1 more source

Thermal behaviour of diclofenac, diclofenac sodium and sodium bicarbonate compositions

Journal of Thermal Analysis and Calorimetry, 2007
This work aims to investigate the thermal behaviour of diclofenac, diclofenac sodium, and NaHCO3 both as single components and binary mixtures. In particular, the melting point and latent heat of fusion binary diagrams of the diclofenac sodium/diclofenac mixtures at different mole fraction compositions were investigated in order to gain information ...
Irene Pasquali, R. Bettini, F. Giordano
openaire   +1 more source

Electrospun Multifunctional Diclofenac Sodium Releasing Nanoscaffold

Journal of Nanoscience and Nanotechnology, 2006
Electrospinning is a method utilized to produce nano-scale fibers for tissue engineering applications. A variety of cells are attracted by nano scale surfaces and structures probably due to the similarity of their natural environment scale. In this study, diclofenac sodium (DS) releasing nanofibers were manufactured via electrospinning process.
L, Nikkola, J, Seppälä, A, Harlin, A, Ndreu, N, Ashammakhi   +4 more
openaire   +2 more sources

Diclofenac Sodium Injection (Dyloject®)

Drugs, 2008
*A new formulation of the nonselective NSAID diclofenac sodium suitable for intravenous bolus injection has been developed using hydroxypropyl beta-cyclodextrin as a solubility enhancer (HPbetaCD diclofenac). * HPbetaCD diclofenac intravenous bolus injection was shown to be bioequivalent to the existing parenteral formulation of diclofenac containing ...
Paul L, McCormack, Lesley J, Scott
openaire   +2 more sources

Diclofenac Sodium and Bruising

Annals of Internal Medicine, 1990
Excerpt To the Editor:No reports to date have described prolonged bleeding time and spontaneous bruising with the use of diclofenac sodium.
Uri Khazan, Mary Toth, Anand Mutgi
openaire   +1 more source

Analysis of diclofenac sodium and derivatives

Journal of Pharmaceutical and Biomedical Analysis, 1999
There are two reasons explaining why several researchers have carried out the in vitro release studies of diclofenac sodium (DFNa) using pH media of above 6.5. Firstly the pH dependence of solubility, and secondly the intramolecular cyclization suffered under acidic conditions which causes the salt to become inactivated. Nevertheless, many commercially
M E, Palomo, M P, Ballesteros, P, Frutos
openaire   +2 more sources

Comparative bioavailability of diclofenac hydroxyethylpyrrolidine vs diclofenac sodium in man

European Journal of Clinical Pharmacology, 1990
A phamacokinetic study in man has been made of a new dosage form of diclofenac hydroxyethylpyrrolidine (DIEP); soluble salt packed in sachets was compared with diclofenac sodium as enteric coated tablets. Oral DIEP 2 X 50 mg showed a significant difference in absorption kinetics (ka, lag time and tmax) as compared to oral diclofenac sodium 2 X 50 mg. A
C A, Maggi, P, Lualdi, G, Mautone
openaire   +2 more sources