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An on‐surface Diels–Alder reaction [PDF]
Angewandte Chemie - International Edition, 2021 AbstractThe Diels–Alder reaction is one of the most popular reactions in organic chemistry. However, its use in the field of on‐surface synthesis is hampered by the spatial restrictions of this cycloaddition reaction. Herein we selected a cyclic strained triyne to demonstrate an on‐surface hexadehydro‐Diels–Alder reaction in a single molecule.
Leo Gross +2 more
exaly +7 more sources
C(alkyl)–C(vinyl) bond cleavage enabled by Retro-Pallada-Diels-Alder reaction [PDF]
Nature Communications, 2023 Activation and cleavage of carbon–carbon (C–C) bonds is a fundamental transformation in organic chemistry while inert C–C bonds cleavage remains a long-standing challenge.
Qingyang Zhao +6 more
doaj +2 more sources
A Simple Entry to the 5,8-Disubstituted Indolizidine Skeleton via Hetero Diels-Alder Reaction [PDF]
Molecules, 2023 The 5,8-disubstituted indolizidines are the largest family of indolizidines isolated from the skin of amphibians. These compounds exhibit interesting biological activities such as noncompetitive blockers of nicotinic receptors.
Juan Francisco Rodríguez-Caro +2 more
doaj +2 more sources
Thermally Induced Intramolecular Diels–Alder Reaction of Furan-Tethered Methylenecyclopropanes [PDF]
MoleculesThe substantial ring strain and activated double bonds render methylenecyclopropanes (MCPs) potential substrates for Diels–Alder (DA) reactions. In this work, we present a thermally induced intramolecular Diels–Alder (IMDA) reaction utilizing furan ...
Qi-Yun Huang +3 more
doaj +2 more sources
New tandem Ugi/intramolecular Diels–Alder reaction based on vinylfuran and 1,3-butadienylfuran derivatives [PDF]
Beilstein Journal of Organic ChemistryA new tandem sequence involving the Ugi reaction and Diels–Alder [4 + 2] cycloaddition based on vinylfuran and 1,3-butadienylfuran derivatives was designed and studied.
Yuriy I. Horak +5 more
doaj +2 more sources
Origin of asynchronicity in Diels–Alder reactions [PDF]
Physical Chemistry Chemical Physics, 2021 Quantum chemical activation strain analyses reveal that asynchronicity in Diels–Alder reactions reduces both destabilizing Pauli repulsion as well as stabilizing orbital interactions, and occurs if the former dominates.
Pascal Vermeeren +2 more
openaire +4 more sources
Organics, 2022 The [2+2+2] cycloaddition (homo-Diels–Alder reaction) of N-substituted 1,2,4-triazoline-3,5-diones (TADs) with bicycloalkadienes produces strained heterocyclic compounds.
Gary W. Breton, Kenneth L. Martin
doaj +1 more source
Self-assembly using a retro Diels-Alder reaction
Nature Communications, 2021 Despite their great utility in synthetic and materials chemistry, Diels-Alder and retro Diels-Alder reactions have been vastly unexplored in promoting self-assembly processes.
Jaeyoung Park +4 more
doaj +1 more source
The hexadehydro-Diels–Alder reaction [PDF]
Nature, 2012 Arynes (aromatic systems containing, formally, a carbon-carbon triple bond) are among the most versatile of all reactive intermediates in organic chemistry. They can be 'trapped' to give products that are used as pharmaceuticals, agrochemicals, dyes, polymers and other fine chemicals.
Hoye, Thomas R. +4 more
openaire +2 more sources
Artificial Enzymes for Diels‐Alder Reactions [PDF]
ChemBioChem, 2020 AbstractThe Diels‐Alder (DA) reaction is a cycloaddition of a conjugated diene and an alkene (dienophile) leading to the formation of a cyclohexene derivative through a concerted mechanism. As DA reactions generally proceed with a high degree of regio‐ and stereoselectivity, they are widely used in synthetic organic chemistry. Considering eco‐conscious
Ghattas, Wadih +3 more
openaire +3 more sources