Results 1 to 10 of about 648 (69)

A Novel Application of Maleimide for Advanced Drug Delivery: In Vitro and in Vivo Evaluation of Maleimide-Modified pH-Sensitive Liposomes

International Journal of Nanomedicine, 2013
Tianshu Li, Shinji TakeokaDepartment of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University (TWIns), Shinjuku-ku, Tokyo, JapanAbstract: Maleimide is a stable and easy-to-handle moiety that rapidly ...
Shinji Takeoka, Tianshu Li
exaly   +2 more sources

Maleimide-Functionalized Liposomes: Prolonged Retention and Enhanced Efficacy of Doxorubicin in Breast Cancer with Low Systemic Toxicity

Molecules, 2022
Cell surface thiols can be targeted by thiol-reactive groups of various materials such as peptides, nanoparticles, and polymers. Here, we used the maleimide group, which can rapidly and covalently conjugate with thiol groups, to prepare surface-modified ...
Chuane Tang, Dan Yin, Tianya Liu, Rui Gou, Jiao Fu, Qi Tang, Yao Wang, Liang Zou, Hanmei Li   +8 more
doaj   +1 more source

Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit

Frontiers in Chemistry, 2021
In order to use a Hemoglobin Based Oxygen Carrier as an oxygen therapeutic or blood substitute, it is necessary to increase the size of the hemoglobin molecule to prevent rapid renal clearance.
Chris E. Cooper, Matthew Bird, XiaoBo Sheng, Ji-Won Choi, Gary G.A. Silkstone, Michelle Simons, Natalie Syrett, Riccardo Piano, Luca Ronda, Luca Ronda, Stefano Bettati, Stefano Bettati, Gianluca Paredi, Andrea Mozzarelli, Andrea Mozzarelli, Brandon J. Reeder   +15 more
doaj   +1 more source

Evaluation of Substituted N-Aryl Maleimide and Acrylamides for Bioconjugation

AppliedChem, 2023
Novel SF5-bearing maleimide and acrylamide derivatives were synthesised as potential [18F]radio-prosthetic groups for radiolabelling peptides and proteins.
Hugh G. Hiscocks, Giancarlo Pascali, Alison T. Ung   +2 more
doaj   +1 more source

Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation

Antibodies, 2017
Thiosuccinimide-linked antibody-drug conjugates (ADCs) are susceptible to drug loss over time due to a retro-Michael reaction, which can be prevented by selecting stable conjugation positions or hydrolysis of the thiosuccinimide.
R. James Christie, Arnaud C. Tiberghien, Qun Du, Binyam Bezabeh, Ryan Fleming, Amanda Shannon, Shenlan Mao, Shannon Breen, Jing Zhang, Haihong Zhong, Jay Harper, Herren Wu, Philip W. Howard, Changshou Gao   +13 more
doaj   +1 more source

A BODIPY-Based Probe Enables Fluorogenicity via Thiol-Dependent Modulation of Fluorophore Aggregation

Molecules, 2022
Given the popular usage of BODIPY fluorophores in biological research, their propensity to aggregate in aqueous solution and impact their spectroscopic properties arguably warrants more attention. The probe under study herein serves as a case in point. A
Tak Ian Chio, Akiva J. Grimaldi, Thomas I. Radford, Susan L. Bane   +3 more
doaj   +1 more source

Effect of different kinds of maleimide resins on properties of nitrile rubber

Hecheng xiangjiao gongye, 2021
Curing characteristics，physical and mechanical properties，and thermal oxidative pro-perty of nitrile rubber （NBR） vulcanized by N-cyclohexylmaleimide，2，2′-bis[4-（4-maleimide phenoxy）phenyl]propane （BMP-BMI） and N，N′-（4，4′-diphenylmethane） bismaleimide ...
LI Bo1; DU Dong-hua2; HUANG Xi-dai1; ZHAO Hong-guo1; WU Zhou-quan3; XU Dian-hong1; GONG Zi-qing1; ZHOU Lei1; XIE Song-bai4; WU Yu1; HU Hai-hua1
doaj   +1 more source

Bisindolyl Maleimides and Indolylmaleimide Derivatives—A Review of Their Synthesis and Bioactivity

Pharmaceuticals, 2023
The evolution of bisindolyl maleimides and indolyl maleimide derivatives and their unique biological activities have stimulated great interest in medicinal chemistry programs.
Louise N. Cooney, Kevin D. O’Shea, Hannah J. Winfield, Michael M. Cahill, Larry T. Pierce, Florence O. McCarthy   +5 more
doaj   +1 more source

Injectable Microporous Annealed Particle Hydrogel Based on Guest–Host‐Interlinked Polyethylene Glycol Maleimide Microgels

Advanced NanoBiomed Research, 2022
Microporous annealed particle (MAP) hydrogels have emerged as a versatile biomaterial platform for regenerative medicine. MAP hydrogels have been used for the delivery of cells and organoids but often require annealing post‐injection by an external ...
Adrienne E. Widener, Senthilkumar Duraivel, Thomas E. Angelini, Edward A. Phelps   +3 more
doaj   +1 more source

Efficient synthesis of polyfunctionalized carbazoles and pyrrolo[3,4-c]carbazoles via domino Diels–Alder reaction

Beilstein Journal of Organic Chemistry, 2021
The p-TsOH-catalyzed Diels–Alder reaction of 3-(indol-3-yl)maleimides with chalcone in toluene at 60 °C afforded two diastereoisomers of tetrahydropyrrolo[3,4-c]carbazoles, which can be dehydrogenated by DDQ oxidation in acetonitrile at room temperature ...
Ren-Jie Fang, Chen Yan, Jing Sun, Ying Han, Chao-Guo Yan   +4 more
doaj   +1 more source