Results 1 to 10 of about 223 (69)

A Biosensor for Urea From Succinimide-Modified Acrylic Microspheres Based on Reflectance Transduction

Sensors, 2011
New acrylic microspheres were synthesised by photopolymerisation where the succinimide functional group was incorporated during the microsphere preparation.
Lee Yook Heng, Alizar Ulianas, Musa Ahmad   +2 more
exaly   +3 more sources

Restoring the biological activity of crizanlizumab at physiological conditions through a pH-dependent aspartic acid isomerization reaction

mAbs, 2023
In this study, we report the isomerization of an aspartic acid residue in the complementarity-determining region (CDR) of crizanlizumab as a major degradation pathway.
Fabian Bickel, François Griaud, Wolfram Kern, Frieder Kroener, Manuela Gritsch, Jérôme Dayer, Samuel Barteau, Blandine Denefeld, Chi-Ya Kao-Scharf, Manuel Lang, Izabela Slupska-Muanza, Carla Schmidt, Matthias Berg, Jürgen Sigg, Lina Boado, Dirk Chelius   +15 more
doaj   +1 more source

Succinimides: Synthesis, properties and anticonvulsant activity [PDF]

Hemijska Industrija, 2011
Succinimide is a cycle imide of succinic acid that is present in numerous biologically active compounds including anticonvulsants, antitremor, anti-Parkinson`s agents.
Banjac Nebojša, Trišović Nemanja, Valentić Nataša, Ušćumlić Gordana, Petrović Slobodan   +4 more
doaj   +1 more source

Identification, Efficacy, and Stability Evaluation of Succinimide Modification With a High Abundance in the Framework Region of Golimumab

Frontiers in Chemistry, 2022
Succinimide (Asu) is the intermediate for asparagine deamidation in therapeutic proteins, and it can be readily hydrolyzed to form aspartate and iso-aspartate residues. Moreover, Asu plays an important role in the protein degradation pathways, asparagine
Tao Liu, Tao Liu, Tao Liu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Qingcheng Guo, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Jun Li, Weizhu Qian, Weizhu Qian, Weizhu Qian, Huaizu Guo, Huaizu Guo, Huaizu Guo, Huaizu Guo, Xinli Zhou, Sheng Hou, Sheng Hou, Sheng Hou   +22 more
doaj   +1 more source

Exploration of Succinimide Derivative as a Multi-Target, Anti-Diabetic Agent: In Vitro and In Vivo Approaches

Molecules, 2023
Diabetes mellitus (DM) is counted among one of the leading challenges in the recent era, and it is a life-threatening disorder. Compound 4-hydroxy 3-methoxy phenylacetone (compound 1) was previously isolated from Polygonum aviculare.
Mater H. Mahnashi, Waqas Alam, Mohammed A. Huneif, Alqahtani Abdulwahab, Mohammed Jamaan Alzahrani, Khaled S. Alshaibari, Umar Rashid, Abdul Sadiq, Muhammad Saeed Jan   +8 more
doaj   +1 more source

Characterizations and Assays of α-Glucosidase Inhibition Activity on Gallic Acid Cocrystals: Can the Cocrystals be Defined as a New Chemical Entity During Binding with the α-Glucosidase?

Molecules, 2020
Cocrystallization with co-former (CCF) has proved to be a powerful approach to improve the solubility and even bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
Na Xue, Yutao Jia, Congwei Li, Binnan He, Caiqin Yang, Jing Wang   +5 more
doaj   +1 more source

Solid State Structure and Hydrogen Bonding of Some Cyclic NH Carboximides

Crystals, 2023
Thirteen new crystal structures of cyclic NH carboximides have been determined and are compared with respect to the mode of intermolecular hydrogen bonding observed in the crystal.
R. Alan Aitken, Alexander J. B. Nelson, Alexandra M. Z. Slawin, Dheirya K. Sonecha   +3 more
doaj   +1 more source

Chiral Phosphine Catalyzed Allylic Alkylation of Benzylidene Succinimides with Morita–Baylis–Hillman Carbonates

Molecules, 2023
Owing to their unique chemical properties, α-alkylidene succinimides generally act as versatile synthons in organic synthesis. Compared with well-established annulations, nucleophilic alkylations of α-alkylidene succinimides are very limited. Accordingly,
Chang Liu, Jianwei Sun, Pengfei Li
doaj   +1 more source

Clusteroluminescence from Cluster Excitons in Small Heterocyclics Free of Aromatic Rings

Advanced Science, 2021
The study of nonconventional luminescence is important for revealing the luminescence of natural systems and has gradually drawn the attention of researchers in recent years. However, the underlying mechanism is still inexplicable.
Benzhao He, Jing Zhang, Jianyu Zhang, Haoke Zhang, Xiuying Wu, Xu Chen, Konnie H. S. Kei, Anjun Qin, Herman H. Y. Sung, Jacky W. Y. Lam, Ben Zhong Tang   +10 more
doaj   +1 more source

New Succinimide–Thiazolidinedione Hybrids as Multitarget Antidiabetic Agents: Design, Synthesis, Bioevaluation, and Molecular Modelling Studies

Molecules, 2023
Diabetes mellitus (DM) is a metabolic disorder majorly arising from the pathophysiology of the pancreas manifested as a decline in the insulin production or the tissue’s resistance to the insulin.
Mohammed A. Huneif, Mater H. Mahnashi, Muhammad Saeed Jan, Muhammad Shah, Sultan A. Almedhesh, Seham M. Alqahtani, Mohammad Jamaan Alzahrani, Muhammad Ayaz, Farhat Ullah, Umer Rashid, Abdul Sadiq   +10 more
doaj   +1 more source