Results 1 to 10 of about 260 (70)
Molecules, 2022 Protein deamidation can severely alter the physicochemical characteristics and biological functions of protein therapeutics. Cobratide is a non-addictive analgesic with wide clinical acceptance. However, the Asn residue at position 48 from the N-terminus
Bo Liu +4 more
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Antibodies, 2023 Deamidation, a common post-translational modification, may impact multiple physiochemical properties of a therapeutic protein. MEDI7247, a pyrrolobenzodiazepine (PBD) antibody–drug conjugate (ADC), contains a unique deamidation site, N102, located within
Yue Huang +11 more
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Control of cellular Bcl-xL levels by deamidation-regulated degradation. [PDF]
PLoS Biology, 2013 The cellular concentration of Bcl-xL is among the most important determinants of treatment response and overall prognosis in a broad range of tumors as well as an important determinant of the cellular response to several forms of tissue injury.
So Hee Dho +8 more
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Molecules, 2023 The effects of protein-glutaminase (PG) on calcium sulphate (CaSO4)-induced gels of soy protein isolate (SPI) with different heat treatment levels were investigated.
Xin Li +7 more
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Structural effects of protein aging: terminal marking by deamidation in human triosephosphate isomerase. [PDF]
PLoS ONE, 2015 Deamidation, the loss of the ammonium group of asparagine and glutamine to form aspartic and glutamic acid, is one of the most commonly occurring post-translational modifications in proteins.
Ignacio de la Mora-de la Mora +11 more
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Antibodies, 2023 Asparagine deamidation is a post-translational modification (PTM) that converts asparagine residues into iso-aspartate and/or aspartate. Non-enzymatic asparagine deamidation is observed frequently during the manufacturing, processing, and/or storage of ...
Mingyan Cao +15 more
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Assessing the degradation of ancient milk proteins through site-specific deamidation patterns
Scientific Reports, 2021 The origins, prevalence and nature of dairying have been long debated by archaeologists. Within the last decade, new advances in high-resolution mass spectrometry have allowed for the direct detection of milk proteins from archaeological remains ...
Abigail Ramsøe +8 more
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Frontiers in Chemistry, 2022 Asparagine deamidation and aspartic acid isomerization in the complementarity determining regions (CDRs) of monoclonal antibodies may alter their affinity to the target antigen.
Baubek Spanov +6 more
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Deamidation-related blood biomarkers show promise for early diagnostics of neurodegeneration
Biomarker Research, 2022 Background The strongest risk factor of neurodegenerative diseases (NDDs) is aging. Spontaneous asparaginyl deamidation leading to formation of isoaspartate (isoAsp) has been correlated with protein aggregation in NDDs.
Jijing Wang +8 more
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A chimeric IgE that mimics IgE from patients allergic to acid-hydrolyzed wheat proteins is a novel tool for in vitro allergenicity assessment of functionalized glutens. [PDF]
PLoS ONE, 2017 Acid-hydrolyzed wheat proteins (acid-HWPs) have been shown to provoke severe allergic reactions in Europe and Japan that are distinct from classical wheat allergies.
Olivier Tranquet +8 more
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