Results 21 to 30 of about 18,296 (185)
Peer Community Journal, 2023 Parchment was used as a writing material in the Middle Ages and was made using animal skins by liming them with Ca(OH)2. During liming, collagen peptides containing Glutamine (Q) undergo deamidation resulting in a mass shift of 0.984 Da.
Nair, Bharath +5 more
doaj +1 more source
Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures. [PDF]
PLoS ONE, 2012 The degradation of proteins by asparagine deamidation and aspartate isomerization is one of several chemical degradation pathways for recombinant antibodies.
Katharina Diepold +11 more
doaj +1 more source
Data in Brief, 2022 Paleoproteomics typically involves the destructive sampling of precious bioarchaeological materials. This analysis aims to investigate the proteins identifiable via nanoLC-MS/MS from highly degraded 26th Dynasty Egyptian mummified human remains (NMR.29.1-
Dylan H. Multari +6 more
doaj +1 more source
Machine Learning Enables Accurate Prediction of Asparagine Deamidation Probability and Rate
Molecular Therapy: Methods & Clinical Development, 2019 The spontaneous conversion of asparagine residues to aspartic acid or iso-aspartic acid, via deamidation, is a major pathway of protein degradation and is often seriously disruptive to biological systems.
Jared A. Delmar +4 more
doaj +1 more source
Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation? [PDF]
, 2018 Mass spectrometry has been applied to determine the deamidation sites and the aggregation region of the deamidated human islet amyloid polypeptide (hIAPP).
Chiu, Cookson K. C. +12 more
core +1 more source
Protein asparagine deamidation prediction based on structures with machine learning methods. [PDF]
PLoS ONE, 2017 Chemical stability is a major concern in the development of protein therapeutics due to its impact on both efficacy and safety. Protein "hotspots" are amino acid residues that are subject to various chemical modifications, including deamidation ...
Lei Jia, Yaxiong Sun
doaj +1 more source
Characterization of N-Terminal Asparagine Deamidation and Clipping of a Monoclonal Antibody
Antibodies, 2023 This study presents a novel degradation pathway of a human immunoglobulin G (IgG) molecule featuring a light chain N-terminal asparagine. We thoroughly characterize this pathway and investigate its charge profiles using cation exchange chromatography ...
Jing Zhen +6 more
doaj +1 more source
DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH.
PLoS Biology, 2007 The pro-survival protein Bcl-xL is critical for the resistance of tumour cells to DNA damage. We have previously demonstrated, using a mouse cancer model, that oncogenic tyrosine kinase inhibition of DNA damage-induced Bcl-xL deamidation tightly ...
Rui Zhao +5 more
doaj +1 more source
Foods, 2020 Hydrochloric acid (HCl)-treated wheat protein (HWP) is widely used in various products, including foods, cosmetics and shampoos. Recently, immediate hypersensitivity towards facial soap containing HWP has been reported.
Ryosuke Abe +6 more
doaj +1 more source
Impact of Deamidation on the Structure and Function of Antiapoptotic Bcl‑xL
, 2021 Bcl-xL is an antiapoptotic mitochondrial trans-membrane protein, which is known to play a crucial role in the survival of tumor cells. The deamidation of Bcl-xL is a pivotal switch that regulates its biological function.
Gamze Tanriver (7521413) +2 more
core +2 more sources