Results 41 to 50 of about 18,296 (185)

Towards Celiac-safe foods: Decreasing the affinity of transglutaminase 2 for gliadin by addition of ascorbyl palmitate and ZnCl2 as detoxifiers

Scientific Reports, 2017
Initiation of celiac disease is triggered in the gastrointestinal tract by transglutaminase 2 (TG2) assisted deamidation of gluten peptides. Deamidation is a side-reaction to transamidation and occurs if primary amines are absent.
N. Engstrom, P. Saenz-Méndez, J. Scheers, N. Scheers   +3 more
doaj   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Engineering an anti-CD52 antibody for enhanced deamidation stability

mAbs, 2019
Deamidation evaluation and mitigation is an important aspect of therapeutic antibody developability assessment. We investigated the structure and function of the Asn-Gly deamidation in a human anti-CD52 IgG1 antibody light chain complementarity ...
Huawei Qiu, Ronnie Wei, Julie Jaworski, Ekaterina Boudanova, Heather Hughes, Scott VanPatten, Anders Lund, Jaime Day, Yanfeng Zhou, Tracey McSherry, Clark Q. Pan, Rebecca Sendak   +11 more
doaj   +1 more source

Deamidation of nicotinamide and NMN

, 1961
Deamidation of nicotinamide was first demonstrated in lactic acid bacteria by Hughes and Williamson (1953). Rajagopalan et al. (1958) were the first to report the presence of this enzyme nicotinamide deamidase in vertebrates.
Sarma, P. S., Rajalakshmi, S., Sarma, D. S. R., Sarma, DSR, Sarma, PS, Rajalakshmi, S   +5 more
core   +1 more source

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

The Accurate Prediction of Antibody Deamidations by Combining High-Throughput Automated Peptide Mapping and Protein Language Model-Based Deep Learning

Antibodies
Therapeutic antibodies such as monoclonal antibodies (mAbs), bispecific and multispecific antibodies are pivotal in therapeutic protein development and have transformed disease treatments across various therapeutic areas.
Ben Niu, Benjamin Lee, Lili Wang, Wen Chen, Jeffrey Johnson   +4 more
doaj   +1 more source

Extensive deamidation of RNase A inhibits its oligomerization through 3D domain swapping

, 2017
Bovine pancreatic ribonuclease A (RNase A) is the monomeric prototype of the so-called secretory 'pancreatic-type' RNase super-family. Like the naturally domain-swapped dimeric bovine seminal variant, BS-RNase, and its glycosylated RNase B isoform, RNase
Caloiu, Andra, FAGAGNINI, ANDREA, MONTIOLI, Riccardo, Ribó, Marc, Laurents, Douglas V., GOTTE, Giovanni   +5 more
core   +1 more source

An Infusible Decellularized Extracellular Matrix Material Binds to Vasculature in Infarcted Myocardium and Induces Pro‐Reparative Gene Expression Following Acute Myocardial Infarction Through Inherent Avidity and Bioactive Signaling

Advanced Science, EarlyView.
To better characterize an infusible extracellular matrix (iECM) material, we applied size‐based fractionation to separate out components into two major fractions. We characterized these fractions to understand how material properties such as composition, morphology, and biochemical properties affect bioactive effects in the context of acute myocardial ...
Michael B. Nguyen, Alexander Chen, Quincy Lyons, Van K. Ninh, Maxwell C. McCabe, Colin Luo, Benjamin D. Bridgelal, Connor Uhre, Julian Cheng, Kate E. Reimold, Selena Cao, Kirk C. Hansen, Kevin R. King, Karen L. Christman   +13 more
wiley   +1 more source

Mechanism for spontaneous deamidation of internal asparagine residues in proteins.

, 2015
Mechanism for spontaneous deamidation of internal asparagine residues in proteins.
J. Ramiro Lorenzo (837944), Ignacio E. Sánchez (43924), Leonardo G. Alonso (124584)   +2 more
core   +1 more source

Sequence and Solution Effects on the Prevalence of d-Isomers Produced by Deamidation [PDF]

, 2017
Deamidation of asparagine is a spontaneous and irreversible post-translational modification associated with a growing list of human diseases. While pervasive, deamidation is often overlooked because it represents a relatively minor chemical change ...
Ryan R. Julian, Gomez, Sonia V, Julian, Ryan R, Riggs, Dylan L, Dylan L. Riggs, Sonia V. Gomez   +5 more
core   +1 more source