Results 51 to 60 of about 18,296 (185)

Adaptive Cellular Responsiveness to Electrical Stimulation at the Skin‐Electrode Interface

Advanced Science, EarlyView.
This study presents an adaptive bioelectronic response in which sustained electrical stimulation (ES) upregulates voltage‐gated calcium channels (VGCCs) and enhances cellular sensitivity to subsequent ES at the skin‐device interface. VGCC‐associated adaptive sensitization promotes regenerative wound‐healing responses in vivo, including accelerated ...
Yeon Jae Chang, Soon Jin Choi, Khandoker Asiqur Rahaman, Tae Kyoung Lee, Gwangbin Lee, Jaeyeon Jun, Hyeon‐Jeong Lee, Hophil Min, Hojeong Jeon, Jung Keun Hyun, Hyung‐Seop Han, Jimin Park   +11 more
wiley   +1 more source

Low cross reactivity between wild type and deamidated AAV can lead to false negative results in immune monitoring T-cell assays

Frontiers in Immunology, 2023
During gene therapy trials, immune responses against adeno-associated virus (AAV) vectors are monitored by antibody assays that detect the humoral and T-cell mediated cellular responses to AAV vectors.
So Jin Bing, Stephanee Warrington, Ronit Mazor   +2 more
doaj   +1 more source

Evaluation of the Effect of Trypsin Digestion Buffers on Artificial Deamidation

, 2016
Nonenzymatic deamidation occurs readily under the condition of trypsin digestion, resulting in the identification of many artificial deamidation sites. To evaluate the effect of trypsin digestion buffers on artificial deamidation, we compared the three ...
Yan Ren (149348), James P. Tam (335549), Piliang Hao (230313), Arnab Datta (586738), Siu Kwan Sze (230315)   +4 more
core   +1 more source

Impact of the Degree of Hydrolysis on the Functional Properties of Rice Proteins – A Review

Cereal Chemistry, EarlyView.
ABSTRACT Background and Objectives Enzymatic hydrolysis has been established as an effective strategy to improve the functional properties of plant proteins. Rice proteins are particularly attractive because of their hypoallergenic nature, high nutritional value, and sustainability, although their technological applications remain limited by their low ...
Poliana Martins de Ávila, Maria Gabriela Bello Koblitz   +1 more
wiley   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication

Toxins, 2017
The AB-type protein toxin from Pasteurella multocida (PMT) contains a functionally important disulfide bond within its catalytic domain, which must be cleaved in the host cell cytosol to render the catalytic domain of PMT into its active conformation ...
Stefan Carle, Thorsten Brink, Joachim H. C. Orth, Klaus Aktories, Holger Barth   +4 more
doaj   +1 more source

Z‐Scheme BiOCl‐Based Photocatalysts: Recent Advances in Designing, Structural Engineering, Formation Mechanisms, and High Performance Photocatalytic Environmental Remediation

EcoEnergy, EarlyView.
This review deals with the recent advancements in design and engineering of BiOCl‐based Z‐scheme photocatalysts with emphasis on tailoring of structural, optoelectronic properties and heterojunction assembly for environmental applications including photodegradation of industrial organic waste, pharmaceuticals, pesticides, herbicides, toxic heavy metals,
Sakshi Sharma, Neha Kaushal, Victor Ezebuiro, Monika Sindhu, Lovepreet Singh, Yugesh Singh Thakur, Hendrik C. Swart, Jai Prakash   +7 more
wiley   +1 more source

Identification, Efficacy, and Stability Evaluation of Succinimide Modification With a High Abundance in the Framework Region of Golimumab

Frontiers in Chemistry, 2022
Succinimide (Asu) is the intermediate for asparagine deamidation in therapeutic proteins, and it can be readily hydrolyzed to form aspartate and iso-aspartate residues. Moreover, Asu plays an important role in the protein degradation pathways, asparagine
Tao Liu, Tao Liu, Tao Liu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Qingcheng Guo, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Jun Li, Weizhu Qian, Weizhu Qian, Weizhu Qian, Huaizu Guo, Huaizu Guo, Huaizu Guo, Huaizu Guo, Xinli Zhou, Sheng Hou, Sheng Hou, Sheng Hou   +22 more
doaj   +1 more source

Age-dependent deamidation of glutamine residues in human γS crystallin: Deamidation and unstructured regions

, 2012
Link to a related website: http://europepmc.org/articles/pmc3403444?pdf=render, Open Access via UnpaywallHuman aging is associated with the deterioration of long-lived proteins.
Hooi, M., Raftery, M., Truscott, R.
core   +1 more source

Enhanced Photocatalytic Antibiotic Micropollutants Removal Resulting From a Synergism Between Cu Single Atoms and Carbon Vacancies on Graphitic Carbon Nitride

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Scheme of the synergistic degradation for antibiotic micropollutants in the Cu/ag‐C3N4 system. Photocatalytic processes driven by visible‐light irradiation offer a sustainable means of micropollutants removal from aquatic environments without the addition of reagents.
Xiaozhe Song, Cong Yan, Qinghua Yan, Congzhe Ren, Xin Liu, Ruiyan Zhang, Lei Chen, Chongqing Xu, Zhouyang Long, Wenyu Wang, Mingming Song, Xiaoguo Shi, Hui Wang   +12 more
wiley   +1 more source