Results 11 to 20 of about 18,296 (185)

Purification of Protein Glutaminase by Cell Surface Display and Krill Protein Modification via Deamidation [PDF]

Foods
In this study, a novel protein glutaminase derived from Chryseobacterium lactis CGMCC 33780 (CLPG) was successfully purified via a one-step cell surface display approach, yielding its mature form.
Jiacheng Zhang, Yu Zhang, Ting Wang, Xu Li, Xiujuan An, Chong Zhang   +5 more
doaj   +2 more sources

Mechanochemical unfolding facilitates protein-glutaminase deamidation and charge remodeling of myofibrillar protein to reduce low-salt-induced aggregation tendency [PDF]

Current Research in Food Science
Low-salt-induced aggregation tendency of myofibrillar protein (MP) reduces its solubility and functional performance under low ionic strength conditions.
Ningle Yang, Yating Liu, Xin Chen, Zongyun Yang, Zhen Li, Yating Xiong, Xinglian Xu, Peng Wang   +7 more
doaj   +2 more sources

Advances in the Study of Protein Deamidation: Unveiling Its Influence on Aging, Disease Progression, Forensics and Therapeutic Efficacy

Proteomes
Protein deamidation, a nonenzymatic post-translational modification that converts asparagine and glutamine residues into their acidic forms, such as aspartic acid, iso-aspartic acid, or glutamic acid, has emerged as a pivotal process affecting protein ...
Sunil S. Adav
doaj   +2 more sources

Prediction of Spontaneous Protein Deamidation from Sequence-Derived Secondary Structure and Intrinsic Disorder. [PDF]

PLoS ONE, 2015
Asparagine residues in proteins undergo spontaneous deamidation, a post-translational modification that may act as a molecular clock for the regulation of protein function and turnover.
J Ramiro Lorenzo, Leonardo G Alonso, Ignacio E Sánchez   +2 more
doaj   +2 more sources

HSV-1 UL42 and UL47 hijack cellular nucleotide synthetic enzyme CAD to promote lytic replication [PDF]

Journal of Virology
Cellular metabolic enzymes are well defined for their roles in metabolism, and their function beyond metabolism is poorly defined. Here, we report that herpes simplex virus 1 (HSV-1) couples evasion of the inflammatory response to metabolic activation to
Chao Qin, Xinchi Xie, Taolin Xie, Zhenhao An, Woo-Chang Chung, Pinghui Feng   +5 more
doaj   +2 more sources

Effects of deamidation by protein glutaminase on the flavor binding properties of pea protein isolate [PDF]

Food Chemistry: X
This study aimed to investigate the effects of protein deamidation by protein glutaminase (PG) on the flavor binding properties of pea protein isolate (PPI), using vanillin as a model.
Panatthida Siripitakpong, Thanakorn Wongprasert, Thanyada Rungrotmongkol, Inthawoot Suppavorasatit   +3 more
doaj   +2 more sources

Impact of Structural Flexibility on Tunneling Contribution to the Reaction Mechanism of Spontaneous Succinimide Formation in Asn-Gly-Containing Peptides [PDF]

Biomolecules
Spontaneous deamidation and isomerization of asparagine (Asn) residues is a major pathway of nonenzymatic protein aging, where Asn-Gly-containing peptides (NG motifs) represent the most reactive sequence.
Fruzsina Pilhál, Bianka Szalainé Ágoston, Imre Jákli, Ernő Keszei, András Perczel   +4 more
doaj   +2 more sources

Analysis of Glutamine Deamidation: Products, Pathways, and Kinetics [PDF]

, 2019
This manuscript examines glutamine deamidation, which is a spontaneous chemical modification similar to the much more thoroughly characterized asparagine deamidation.
Dylan L., Riggs, Jacob W., Silzel, Yana A., Lyon, Amrik S., Kang, Ryan, Julian   +4 more
core   +5 more sources

Impact of deamidation on the structure and function of anti-apoptotic Bcl-xL. [PDF]

, 2021
Bcl-xL is an anti-apoptotic mitochondrial trans-membrane protein, known to play a crucial role in the survival of tumor cells. The deamidation of Bcl-xL is a pivotal switch that regulates its biological function.
Saron, Catak, Gamze, Tanriver, Gerald, Monard   +2 more
core   +2 more sources

N‑Linked Glycosylation Prevents Deamidation of Glycopeptide and Glycoprotein [PDF]

, 2020
Deamidation has been recognized as a common spontaneous pathway of protein degradation and a prevalent concern in the pharmaceutical industry; deamidation caused the reduction of protein/peptide drug efficacy and shelf life in several cases.
Tran, Vy P., Liu, Ding, Zhang, Jiabin, Xue, Bingzhong, Zhu, Joshua, Zhu, He, Shi, Hang, Wang, Peng George, Gibbons, Christopher, Wu, Zhigang, Jiang, Kuan, Christopher Gibbons, Jiabin Zhang, Hang Shi, Peng George Wang, Zhigang Wu, Hailiang Joshua Zhu, Bingzhong Xue, Vy P. Tran, Ding Liu, He Zhu, Kuan Jiang   +21 more
core   +1 more source