Results 41 to 50 of about 43,444 (345)

Maleimide-oligo(ethylene glycol) Derivatives of Camptothecin as Albumin-Binding Prodrugs:  Synthesis and Antitumor Efficacy

, 2016
In situ binding of thiol-reactive prodrugs to the cysteine-34 position of circulating albumin is a new approach in drug delivery. Therefore, five maleimide-bearing derivatives of the anticancer drug camptothecin (CPT) were developed as albumin-binding ...
Felix Kratz (1926430), André Warnecke (2454520)   +1 more
core   +1 more source

Photoinduced Transformations with Diverse Maleimide Scaffolds

Molecules
Maleimides serve as crucial components in various synthetic processes and are of significant interest to researchers in bioorganic chemistry and biotechnology.
Jayachandran Parthiban, Dipti Garg, Jayaraman Sivaguru   +2 more
doaj   +1 more source

Automated three-component synthesis of a library of γ-lactams

Beilstein Journal of Organic Chemistry, 2012
A three-component method for the synthesis of γ-lactams from commercially available maleimides, aldehydes, and amines was adapted to parallel library synthesis. Improvements to the chemistry over previous efforts include the optimization of the method to
Erik Fenster, David Hill, Oliver Reiser, Jeffrey Aubé   +3 more
doaj   +1 more source

Synthesis of substituted N-phenylmaleimides and use in a Diels–Alder reaction: a green multi-step synthesis for an undergraduate organic chemistry laboratory

Green Chemistry Letters and Reviews, 2019
This paper describes the design and implementation of a minimally hazardous, environmentally friendly, and energy efficient sequential reaction sequence within a sophomore level Organic Chemistry lab course to efficiently synthesize N-phenylmaleimide ...
Loyd D. Bastin, Manisha Nigam, Sam Martinus, James E. Maloney, Landon L. Benyack, Brendan Gainer   +5 more
doaj   +1 more source

A Rapid Crosslinkable Maleimide-Modified Hyaluronic Acid and Gelatin Hydrogel Delivery System for Regenerative Applications

Gels, 2021
Hydrogels have played a significant role in many applications of regenerative medicine and tissue engineering due to their versatile properties in realizing design and functional requirements.
Kyung Min Yoo, Sean V. Murphy, Aleksander Skardal   +2 more
doaj   +1 more source

Thermally Reversible and Recyclable Polyethylene Networks via Furan-Maleimide Diels-Alder Dynamic Covalent Chemistry. [PDF]

Molecules
Hao Z, Zhang W, Liu Y, Xu J, Liu H, Tang S, Shen J.   +6 more
europepmc   +3 more sources

Oligonucleotide cyclization: The thiol-maleimide reaction revisited [PDF]

, 2014
A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol ...
Grandas Sagarra, Anna, Pedroso Muller, Enrique, Sánchez-Moya, Albert   +2 more
core   +1 more source

Evaluation of hemolysis interference and possible protective effect of N-phenyl maleimide on the measurement of small peptides

Türk Biyokimya Dergisi, 2022
This study aims to demonstrate that proteolytic enzymes released as a result of hemolysis decrease the small peptide hormones, whereas N-phenyl maleimide (NPM) can be used to prevent hemolysis interference.
Durmaz Mustafa, Erguder Imge
doaj   +1 more source

A Facile Procedure for One-Pot Stable Conjugation of Two Proglucagon Cysteine-Containing Peptide Analogs

Frontiers in Endocrinology, 2021
Optimization of peptides for therapeutic purposes often includes chemical conjugation or modification with substituents that serve to broaden pharmacology or improve pharmacokinetics.
Rongjun He, Stephanie A. Mowery, Joseph Chabenne, Brian Finan, John P. Mayer, Richard D. DiMarchi   +5 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source