Results 131 to 140 of about 1,252,753 (304)

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

The Diet in Diabetes [PDF]

BMJ, 1943
openaire   +2 more sources

Diabetic foot disease and oedema [PDF]

, 2013
Diabetic foot ulcers (DFUs) are common and disabling, giving rise to significant morbidity and mortality as well as worldwide socioeconomic problems. Despite treatment, DFUs readily become chronic wounds and may lead to major lower limb amputations.
Leigh, RD, Tsui, J, Ho, TK
core  

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Loss of Intestinal MSTN Promotes GLP‐1 Secretion Through SGLT1 Palmitoylation

Advanced Science, EarlyView.
Intestinal MSTN deficiency enhances glucose‐stimulated GLP‐1 secretion and glucose tolerance in high‐fat diet‐fed mice. Mechanistically, loss of MSTN promotes YY1‐associated ZDHHC20 expression, increasing SGLT1 S‐palmitoylation at Cys301 and its plasma membrane localization in L cells.
Sheng‐Zhong Han, Shuang‐Yan Chang, Zhaobo Luo, Ke Sun, Biaohu Quan, Yanqiu Lv, Zhouyan Li, Xinyue Liu, Sitong Lv, Meifu Xuan, Xiaoyufan Xu, Xue Fang, Hang Chang, Rihuan Zhang, Xi‐Jun Yin, Lin‐Hu Quan, Jin‐Dan Kang   +16 more
wiley   +1 more source

Hepatocyte CBX2 Safeguards Hepatic Lipid Homeostasis by Elevating Ca2+‐CaMKK2‐AMPK Signaling to Counter MASLD

Advanced Science, EarlyView.
In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei, Li Lin, Xiuyun Wang, Hui Du, Menglong Zhang, Kechao Tang, Han Gao, Xinrui Xie, Jingya Gao, Xu Wang, Zhenglin Wang, Siwei Huang, Lei Zhang, Fang Gu, Gong‐Hong Wei, Yinliang Qi, Wei Chen, Yongsheng Chang, Huabing Zhang   +18 more
wiley   +1 more source

Effects of Different Carbohydrate Content Diet on Gut Microbiota and Aortic Calcification in Diabetic Mice

Diabetes, Metabolic Syndrome and Obesity
Xinyi Shen,1,2 Ge Guo,1,2 Guoquan Feng,3 Zhongqun Wang1,2 1Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, People’s Republic of China; 2Institute of Cardiovascular Diseases, Jiangsu University, Zhenjiang, 212001 ...
Shen X, Guo G, Feng G, Wang Z
doaj  

Mediterranean diet and diabetic microvascular complications: a systematic review and meta-analysis

BMC Nutrition
Background Diabetic microvascular complications, including diabetic retinopathy (DR), diabetic nephropathy (DN), and diabetic peripheral neuropathy (DPN), contribute significantly to morbidity and healthcare burdens among individuals with diabetes.
Diar Zooravar, Pedram Soltani, Saeed Khezri   +2 more
doaj   +1 more source

Diet and the Cornerstones of Diabetes [PDF]

Diabetes Care, 1988
J, Calles-Escandon, D C, Robbins, J T, Devlin   +2 more
openaire   +2 more sources

A Markov model of Diabetic Retinopathy Progression for the Economic Evaluation of a novel DR prognostic device, CHERE Working Paper 2007/14 [PDF]

The initial diagnosis of Diabetic Retinopathy (DR) is often in the advance stages of the condition, as patients are only promoted for an examination when sight has been affected.
Marion Haas, Julia Ting, Donald Martin
core