Results 91 to 100 of about 1,943,434 (254)

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes, but not with insulin resistance [PDF]

, 2014
Mice lacking transcription factor NF-E2 p45-related factor 2 (Nrf2) develop more severe non-alcoholic steatohepatitis (NASH), with cirrhosis, than wild-type (Nrf2(+/+)) mice when fed a high-fat (HF) diet for 24 weeks.
Chowdhry, Sudhir, McCrimmon, Rory J.; id_orcid, Meakin, Paul J.; id_orcid, Dinkova-Kostova, AT, Meakin, PJ, Ashford, FB, Walsh, Shaun V., Chowdhry, S, Sharma, Ritu S., Walsh, SV, Ashford, Fiona B., Sharma, RS, Dillon, JF, Dillon, John F.; id_orcid, Hayes, John D, Hayes, JD, Dinkova-Kostova, Albena T.; id_orcid, Ashford, MLJ, Ashford, Michael L. J.; id_orcid, McCrimmon, RJ   +19 more
core   +1 more source

Differentiating brown and white adipose tissues by high-resolution diffusion NMR spectroscopy

Journal of Lipid Research, 2017
There are two types of fat tissues, white adipose tissue (WAT) and brown adipose tissue (BAT), which essentially perform opposite functions in whole body energy metabolism.
Sanjay Kumar Verma, Kaz Nagashima, Jadegoud Yaligar, Navin Michael, Swee Shean Lee, Tian Xianfeng, Venkatesh Gopalan, Suresh Anand Sadananthan, Rengaraj Anantharaj, S. Sendhil Velan   +9 more
doaj   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

The confusion about dietary fatty acids recommendations for CHD prevention [PDF]

, 2011
A recent meta-analysis of prospective cohort studies has not found an association between dietary saturated fat intake and CHD incidence. This funnelled the discussion about the importance of the recommendation to lower the intake of saturated fat for ...
Jacobs, D.R., Kromhout, D., Geleijnse, J.M., Menotti, A.   +3 more
core   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

MTOR signaling and ubiquitin-proteosome gene expression in the preservation of fat free mass following high protein, calorie restricted weight loss

Nutrition & Metabolism, 2012
Caloric restriction is one of the most efficient ways to promote weight loss and is known to activate protective metabolic pathways. Frequently reported with weight loss is the undesirable consequence of fat free (lean muscle) mass loss.
McIver Cassandra M, Wycherley Thomas P, Clifton Peter M   +2 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

A reappraisal of the impact of dairy foods and milk fat on cardiovascular disease risk [PDF]

, 2009
Background This review provides a reappraisal of the potential effects of dairy foods, including dairy fats, on cardiovascular disease (CVD)/coronary heart disease (CHD) risk.
German, J Bruce, Krauss, Ronald M, Krauss, R., Ronald M. Krauss, Nestel, P., Gibson, Robert A, van Staveren, W.A., Steijns, J.M., Lock, A.L., German, B., Adam L. Lock, de Groot, C.P.G.M., van Staveren, Wija A, Steijns, Jan M, Lock, A., Jan M. Steijns, Staveren, W.A., van, Gibson, R., de Groot, L., de Groot, Lisette CPGM, Krauss, R.M., J. Bruce German, Lock, Adam L, Wija A. van Staveren, van Staveren, W., Destaillats, Frédéric, Nestel, Paul, Lisette C. P. G. M. de Groot, Paul Nestel, Groot, C.P.G.M., de, Lamarche, Benoît, Destaillats, F., Gibson, R.A., Lamarche, B., Benoît Lamarche, Steijns, J., German, J.B., Robert A. Gibson, Frédéric Destaillats   +38 more
core   +1 more source

The ketogenic diet and other dietary treatments for refractory epilepsy in children

Annals of Indian Academy of Neurology, 2014
The ketogenic diet is a high-fat, low-carbohydrate, and restricted protein diet that is useful in patients with refractory epilepsy. The efficacy of the ketogenic diet is better than most of the new antiepileptic drugs.
Suvasini Sharma, Puneet Jain
doaj   +1 more source