Results 151 to 160 of about 455,114 (311)

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Climate Change Threatens Micronutrient Density of European Winter Wheat

Advanced Science, EarlyView.
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao, Jennifer Michel, Eline Lorer, Markus Weinmann, Jacques Le Gouis, Claire Léon, Sibille Perrochon, David Alvarez, Vincent Leemans, Iñaki Balanzategui Guijarro, Jordi Moya Laraño, Sara Sánchez Moreno, Symanczik Sarah, Waibel Matthias, Hervé Vanderschuren, Cécile Thonar, Pierre Delaplace, Dominique Van Der Straeten   +17 more
wiley   +1 more source

The importance of reducing SFA to limit CHD [PDF]

, 2011
James, P.T., Elmadfa, I, Uusitupa, Matti, Kris-Etherton, P., Mike Rayner, Brouwer, I.A.; id_orcid, Ibrahim Elmadfa, Mensink, RP, Jan I. Pedersen, Daan Kromhout, Rayner, Mike, Katan, M.B., Kris Etherton, P.M., Mensink, Ronald P., Ingeborg A. Brouwer, Brouwer, IA, Kaare R. Norum, Ronald P. Mensink, Kromhout, D., Kris-Etherton, PM, Katan, Martijn B., Pedersen, J.L., Katan, MB, Pedersen, JI, Kris-Etherton, Penny M, Matti Uusitupa, Clarke, Robert, Clarke, R, Norum, K.R., Kromhout, Daan, Mensink, R.P., Pedersen, Jan I., Kromhout, D, Elmadfa, Ibrahim, Rayner, M., James, Philip T., Margetts, Barrie M., Pedersen, J.I., Clarke, R., Margetts, BM, Norum, Kaare R., Brouwer, I.A., Robert Clarke, Barrie M. Margetts, Margetts, B.M., Norum, KR, Katan, M.B.; id_orcid, Rayner, M, Uusitupa, M., Elmadfa, I., Brouwer, Ingeborg A., Martijn B. Katan, Philip T. James, Kris-Etherton, P.M., Penny M. Kris-Etherton, Uusitupa, M, James, PT   +56 more
core   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Effects of dietary changes on heat stress in broiler and Kampung chickens

, 2012
Poultry meat production has increased drastically over the last 35 years. Most developing countries are in the tropics and often have high ambient temperatures.
Syafwan, W.
core  

Adult Refsum Disease: Case Series of Reducing Circulating Phytanic Acid Levels With Dietary Interventions. [PDF]

JIMD Rep
Firman SJ, Cook J, Hall I, Yeung K, Buttigieg R, Vaz F, Wierzbicki AS, Ramachandran R.   +7 more
europepmc   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Assessment of psychoemotional state of overweight and obese women after reducing diet

, 2017
WSTĘP: Szczególną skłonność do otyłości i nadwagi przejawiają kobiety w okresie okołomenopauzalnym. Dietetyczne leczenie zespołów hiperalimentacji w tej grupie może mieć skutki wielowymiarowe.
Loba, Małgorzata, Górska-Ciebiada, Małgorzata, Walecka-Kapica, Ewa, Łokieć, Katarzyna   +3 more
core