Results 61 to 70 of about 78,883 (301)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Severe feed restriction increases permeability of mammary gland cell tight junctions and reduces ethanol stability of milk

Animal, 2013
A total of twelve lactating Jersey cows were used in a 5-week experiment to determine the effects of severe feed restriction on the permeability of mammary gland cell tight junctions (TJs) and its effects on milk stability to the alcohol test. During the
M.T. Stumpf, V. Fischer, C.M. McManus, G.J. Kolling, M.B. Zanela, C.S. Santos, A.S. Abreu, P. Montagner   +7 more
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Correlation between Type D Personality and Adherence to Low-Sodium Diet in Patients with Systolic Heart Failure

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2017
Background and Objectives: Adherence to low-sodium diet is an important aspect of self-care behaviors, which plays a role in improving the quality of life, and in reducing readmission rate, mortality, and healthcare costs. This study aimed to investigate
Sharareh Zeighami Mohammadi, Esmat Danesh, Parvin Farmani, Manijeh Shakoor, Farzad Fahidy, Behnam Mohseni, Ebrahim Fallah Taherpazir   +6 more
doaj  

A Comprehensive Overview on Necessity and Strategies of Salt Intake Reduction in the Population [PDF]

Taṣvīr-i salāmat, 2017
Non-communicable diseases (NCDs) have become a major public health problem not only in developed countries, but also in developing countries; as cardiovascular disease is considered to be the leading cause of death in the world.
Fathollah Pourali, Zahra Abdollahi, Leila Roufegarinejad, Jafar Sadegh Tabrizi, Ahmad koosha   +4 more
doaj  

What evidence for the benefits of ‘5-a-day’, a Mediterranean diet and sodium restriction on health? [PDF]

Drug and Therapeutics Bulletin, 2015
Guidelines for healthcare professionals encourage the provision of dietary advice to promote healthy eating, especially to patients at risk of chronic disease.1 Yet the evidence base for dietary interventions relies heavily on epidemiological studies, which are subject to the challenges associated with observational research.
openaire   +2 more sources

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Impacts of salt restriction on nutritional status, sarcopenia, and mortality of cirrhotic patients with ascites

BMC Gastroenterology
Background Salt restriction is a cornerstone in managing ascites in cirrhotic patients; however, its impact on nutritional status, sarcopenia, and mortality remains unclear.
Maha Elsabaawy, Mohammed Ragab, Madiha Naguib, Eman Kamal, Maymona Al-Khalifa, Khaled Gamil, Marwa Elfayoumy   +6 more
doaj   +1 more source

Renal sodium handling and blood pressure changes in gestational protein-restricted offspring: Role of renal nerves and ganglia neurokinin expression.

PLoS ONE, 2017
BackgroundConsidering long-term changes in renal sodium handling and blood pressure in maternal protein-restricted (LP) offspring, we assumed that the development of LP hypertension results from abnormal dorsal root ganglia (DRG) neurokinin expression ...
Augusto H Custódio, Marcelo C de Lima, Bárbara Vaccari, Patrícia A Boer, José A R Gontijo   +4 more
doaj   +1 more source