Results 261 to 270 of about 2,649,462 (341)

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

Impact of healthy and sustainable diets on the mortality burden from cardiometabolic diseases and colorectal cancer in Mexican adults: a modeling study. [PDF]

BMC Public Health
Arango-Angarita A, Unar-Munguía M, Zepeda-Tello R, Batis C, Rivera JA.   +4 more
europepmc   +1 more source

A MXene‐Based Nanothermal Knife Inhibits Aggresome‐Mediated Persister Formation for Preventing Dental Caries

Advanced Science, EarlyView.
Early childhood caries (ECC) involves cariogenic persisters that evade antimicrobial treatment. Persisters achieve this by downregulating heat shock proteins (HSPs) and formation of protein aggregates. Ti3C2 MXene‐based photothermal therapy (PTT) acts as a “nanothermal knife,” disrupting membranes, upregulating HSPs, inhibits aggregates, prevents ...
Yinyin Zhang, Leilei Yang, Jing jiao, Wenshuai Li, Sen Lin, Xianlong Zong, Haoyang Qin, Danfeng Liu, Rui Li   +8 more
wiley   +1 more source

The Correlation Between Carbohydrate Loading Diet and Gut Microbiome: A Systematic Review. [PDF]

Microbiologyopen
El-Kholy O, Nichols L, Elsayed AAR, Basson MD.   +3 more
europepmc   +1 more source

Ligilactobacillus Murinus and Lactobacillus Johnsonii Suppress Macrophage Pyroptosis in Atherosclerosis through Butyrate‐GPR109A‐GSDMD Axis

Advanced Science, EarlyView.
Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua, Ning Ding, Yiming Hua, Xiaoke Wang, Yu Xu, Xiangrui Qiao, Xue Shi, Ting Bai, Ying Xiong, Xiaozhen Zhuo, Chong Fan, Juan Zhou, Yue Wu, Junhui Liu, Zuyi Yuan, Ting Li   +15 more
wiley   +1 more source

Gompertz Law‐Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Ageing to Capture Morbidity and Mortality Risks

Advanced Science, EarlyView.
The Gompertz law‐based biological age metric (GOLD BioAge) introduces interpretable convenient and interpretable calculations to capture mortality, disease, and frailty risks. Its applications to proteomics and metabolomics (ProtAge and MetAge) demonstrate clinical potential to enhance aging evaluation and prevent age‐related diseases.
Meng Hao, Hui Zhang, Jingyi Wu, Yaqi Huang, Xiangnan Li, Meijia Wang, Shuming Wang, Jiaofeng Wang, Jie Chen, Zhi jun Bao, Li Jin, Xiaofeng Wang, Zixin Hu, Shuai Jiang, Yi Li   +14 more
wiley   +1 more source

ON A TYPE OF OPHTHALMIA CAUSED BY UNSATISFACTORY RELATIONS IN THE INORGANIC PORTION OF THE DIET. AN OPHTHALMIA NOT DUE TO STARVATION FOR FAT-SOLUBLE A, AND NOT CURABLE BY ITS ADMINISTRATION

, 1922
E. V. McCollum, Nina Simmonds, J. Ernestine Becker   +2 more
openalex   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu, Shaobo Kang, Na Lin, Wenqi Zhang, Shiwen Wang, Yuqing Ren, Xiaofan Ding, Jianxiu Yu, Ruiyu Xie   +8 more
wiley   +1 more source

Effect of intermittent fasting, portfolio-moderate-carbohydrate, and anti-inflammatory diets on cardio-metabolic status in pre-diabetic patients; an open-label randomized clinical trial. [PDF]

Diabetol Metab Syndr
Pasdar Y, Saber A, Rezvani N, Bozorgi S, Moradi S, Cheshmeh S, Niazi H, Najafi F.   +7 more
europepmc   +1 more source