Results 171 to 180 of about 3,278,096 (257)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Characterization of a metabolomics signature of the brain-health-promoting MIND diet in older persons. [PDF]

J Prev Alzheimers Dis
Neuffer J, González-Domínguez R, Lefèvre-Arbogast S, Low DY, Tor-Roca A, Helmer C, Preez AD, de Lucia C, Ruigrok SR, Altendorfer B, Aigner L, Lucassen PJ, Korosi A, Thuret S, Manach C, Pallàs M, Sánchez-Pla A, Andres-Lacueva C, Urpi-Sarda M, Samieri C.   +19 more
europepmc   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

Adolescent-Selected Food Intake and Engagement with the External Food Environment Contribute to Unhealthy Diets in Accra, Ghana. [PDF]

Curr Dev Nutr
Becquey E, Zagré RR, Ogum D, Huybregts L, Aryeetey R, Ruel MT, Leroy JL.   +6 more
europepmc   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Can the development of cooking skills influence nutritional status and diet? A systematic review. [PDF]

PLoS One
Andrade EDO, Freitas ÉPS, Nascimento DSMD, Pelonha RNDC, Galvão LLP, Nascimento ABD, Piuvezam G, Jomori MM, Passos TS, Maciel BLL.   +9 more
europepmc   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Soil-Plant-Animal Mineral Dynamics in Extensive Goat Production Systems: A Critical Review of Geochemical Availability, Soil-Plant Transfer, and Ruminal Bioavailability. [PDF]

Animals (Basel)
Rivera-Larraga JE, Olazaran-Santibañez FE, Mora-Olivo A, Reyes AG, Díaz-Sánchez VM, López-Aguirre D, Aguirre-Guzmán G, Zapata-Campos CC.   +7 more
europepmc   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Adherence to the Mediterranean diet and its effects on the onset and progression of diabetic nephropathy: a systematic review. [PDF]

Ren Fail
Sykaras I, Kantilafti M, Chrysostomou S.
europepmc   +1 more source