Results 151 to 160 of about 370,458 (305)

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Intrahousehold empowerment gaps and dietary diversity in China

Frontiers in Nutrition
ObjectiveThis article analyzes the relationship between intrahousehold empowerment gaps and food and nutrition security using quantitative data collected through a household survey organized by the Agricultural Information Institute, Chinese Academy of Agricultural Sciences (CAAS-AII), in 2023.MethodsBased on empowerment theory, this study measured the
Yanfang Huang, Yuying Yang, Fengying Nie, Xiangping Jia   +3 more
openaire   +3 more sources

Dietary diversity and its associated factors among children aged 6–23 months in mauritania: evidence from national survey

BMC Nutrition
Introduction Dietary diversity is a key determinant of child nutrition and development, particularly for children aged 6–23 months. Not meeting minimum dietary diversity increases the risk of malnutrition, which remains a major public health concern in ...
Hiwot Altaye Asebe, Gilbert Eshun, Betelhem Abebe Andargie   +2 more
doaj   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Maternal dietary diversity increases with women's high decision-making autonomy in Northwest Ethiopia, 2022

Heliyon
Background: Dietary diversification is one of several approaches for improving micronutrient levels in women of reproductive age. Therefore, this study aimed to assess the magnitude of minimum dietary diversity among pregnant women, explore the ...
Habitamu Mekonen, Melese Linger Endalifer, Bayou Tilahun Assaye   +2 more
doaj   +1 more source

No. 02: The State of Urban Food Insecurity in Southern Africa [PDF]

, 2010
The number of people living in urban areas is rising rapidly in Southern Africa. By mid-century, the region is expected to be 60% urban. Rapid urbanization is leading to growing food insecurity in the region’s towns and cities.
Acquah, Ben, Battersby-Lennard, Jane, Bras, Eugenio, Chiweza, Asiyati, Crush, Jonathan, Dlamini, Tebogo, Fincham, Robert, Frayne, Bruce, Kroll, Florian, Leduka, Clement, Mosha, Aloysius, Mulenga, Chileshe, Mvula, Peter, Pendleton, Wade, Pomuti, Akiser, Raimundo, Ines, Rudolph, Michael, Ruysenaa, Shaun, Simelane, Nomcebo, Tawodzera, Godfrey, Tevara, Daniel, Tsoka, Maxton, Zanamwe, Lazarus   +22 more
core   +1 more source

APOE‐stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease

Advanced Science, EarlyView.
A large‐scale multiomic dataset (proteomic and metabolomic) comprising 3,060 plasma samples were analyzed to identify proteins, metabolites, pathways, and protein‐associated drugs linked to Alzheimer’s Disease (AD) independently of apolipoprotein E (APOE). AD was associated with a distinct molecular signature that captures.
Fuhai Li, Yike Chen, Daniel Western, Muhammad Ali, Menghan Liu, Katherine Gong, Ying Xu, Joseph Lowery, David M. Holtzman, Chloe Robins, John D. Eicher, Yen‐Ning Huang, ShiWei Liu, Tamina Park, Andrew J. Saykin, Kwangsik Nho, Mahdi Moqri, Richard C. Mohs, Amelia Farinas, Patricia Moran‐Losada, Hamilton Se‐Hwee Oh, Tony Wyss‐Coray, Carlos Cruchaga   +22 more
wiley   +1 more source

Reciprocal association between dietary diversity and subjective well-being in Chinese older adults: a three-wave longitudinal study

Archives of Public Health
Background Previous studies have shown that diet is closely related to the subjective well-being, but the interaction between dietary diversity and subjective well-being over time has not been reported.
Ting Wang, Juan Feng, Xiaolong Bu, Yanan Wang, Yanni Su, Qian Dong, Feng Zhong, Cuiping Liu   +7 more
doaj   +1 more source

A Natural Sweetener‐inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals

Advanced Science, EarlyView.
This study develops a natural sweetener, the psicose‐inducible transgene expression (PURE) system based on an Agrobacterium tumefaciens–derived transcriptional repressor PsiR. The PURE system is highly specific to psicose, being insensitive to other sugars and structurally similar molecules.
Longliang Qiao, Zhihao Wang, Shasha Tang, Yuan Fang, Guiling Yu, Xiaoting Qiu, Lingxue Niu, Tao Yan, Xingwan Liu, Xiaoding Ma, Deqiang Kong, Yang Zhou, Ningzi Guan, Jinzhong Tian, Meiyan Wang, Haifeng Ye, Fengfeng Cai   +16 more
wiley   +1 more source