ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy
Advanced Science, EarlyView.Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie +11 more
wiley +1 more source
Interactions of Colorectal Cancer, Dietary Fats, and Polymorphisms of Arachidonate Lipoxygenase and Cyclooxygenase Genes: A Literature Review. [PDF]
Front Oncol, 2022 Gholamalizadeh M +12 more
europepmc +1 more source
PFKFB2‐Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury
Advanced Science, EarlyView.Paraquat (PQ) or lipopolysaccharide (LPS) exposure activates the HIF‐1α–PFKFB2 pathway, driving glycolysis in dendritic cells (DCs). This metabolic shift enhances DC maturation and immune activation, exacerbating acute lung injury (ALI). This study demonstrates that PFKFB2‐driven glycolytic reprogramming in DCs plays a critical role in the pathogenesis
Ding Yuan +17 more
wiley +1 more source
Influence of Strain of Chicken and Dietary Fat On Egg Production Traits [PDF]
, 1968 P.A. Kondra, Siew Choo, JERRY L. SELL
openalex +1 more source
Advanced Science, EarlyView.The release of COL6A3 by fibroblasts is sensed by the CD44 receptor on melanocytes, activating glutathione (GSH) metabolism and increasing melanocyte survival during skin organoid culture. SEMA3C released by bulge cells binds to the NRP1 receptor on melanocytes, regulating microtubule stability and promoting melanocyte recruitment and function during ...
Tingting Li +17 more
wiley +1 more source
Molecular Immune-Inflammatory Connections between Dietary Fats and Atherosclerotic Cardiovascular Disease: Which Translation into Clinics? [PDF]
Nutrients, 2021 Mattavelli E, Catapano AL, Baragetti A.
europepmc +1 more source
Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy
Advanced Science, EarlyView.This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou +13 more
wiley +1 more source
Dietary fats and their sources in association with the risk of bladder cancer: A pooled analysis of 11 prospective cohort studies. [PDF]
Int J Cancer, 2022 Dianatinasab M +12 more
europepmc +1 more source
Effect of Source of Carbohydrate as Influenced by Dietary Fat: Carbohydrate ratio and forced exercise in rats [PDF]
, 1968 Richard A. Ahrens +4 more
openalex +1 more source
Advanced Science, EarlyView.Clinical discovery and the proposed underlying mechanism by how P. johnsonii ameliorated metabolic disorders. Abstract The gut bacterium Parabacteroides spp. is increasingly recognized for its therapeutic potential in treating metabolic disorders. However, the role of Parabacteroides johnsonii in metabolic disorders is never reported.
Yimeng Chen +9 more
wiley +1 more source