Results 141 to 150 of about 1,558,656 (326)

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Familial resemblance in dietary intake among singletons, twins, and spouses: a meta-analysis of family-based observations

BMC Public Health
Background Familial dietary intake can be influenced by both genetic and environmental factors; the current study aimed to examine the role of these two factors on dietary intake by investigating the resemblance in energy, nutrient, and food group intake
Farshad Teymoori, Mahdi Akbarzadeh, Mostafa Norouzzadeh, Mitra Kazemi Jahromi, Hossein Farhadnejad, Niloufar Saber, Hamid Ahmadirad, Mina Jahangiri, Danial Habibi, Parisa Riahi, Ebrahim Mokhtari, Maryam Zarkesh, Maryam S. Daneshpour, Parvin Mirmiran, Mohammadreza Vafa   +14 more
doaj   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Impact of Dietary Fats on Cardiovascular Disease with a Specific Focus on Omega-3 Fatty Acids. [PDF]

J Clin Med, 2022
Maggioni AP, Poli G, Mannucci PM.
europepmc   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Economic Impacts of Proposed Limits on Trans Fats in Canada [PDF]

In response to growing concerns about coronary heart disease (CHD), the Government of Canada has recently taken policy measures to reduce Canadian trans fatty acid (TFA) consumption. The mandatory labelling of trans fat content in foods began in December
Gray, Richard S., Malla, Stavroula, Perlich, Ken   +2 more
core   +1 more source

Nutritional quality of dietary patterns of children: are there differences inside and outside school?

Jornal de Pediatria
: Objectives: To describe the dietary patterns of children inside and outside school and investigate their associations with sociodemographic factors and nutritional status.
Diva Aliete dos Santos Vieira, Michelle Alessandra Castro, Mauro Fisberg, Regina Mara Fisberg   +3 more
doaj   +1 more source

Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer's disease: potential interactive effects of APOE genotype with dietary fats. [PDF]

Genes Nutr, 2023
D'Alonzo ZJ, Lam V, Takechi R, Nesbit M, Vaccarezza M, Mamo JCL.   +5 more
europepmc   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Changes in the gene expression profile of the mammary gland lipogenic enzymes in Saanen goats in response to dietary fats. [PDF]

Vet Med Sci, 2023
Javaheri Barfourooshi H, Sadeghipanah H, Asadzadeh N, Seyedabadi H, Borazjani M, Javanmard A.   +5 more
europepmc   +1 more source