Results 281 to 290 of about 173,728 (337)

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR‐δ Signaling Pathway

Advanced Science, EarlyView.
Utilizing PDO, cell lines and cervical cancer xenograft (CDX) models, the study demonstrate both in vitro and in vivo that the metabolite of L. crispatus, erucic acid, can modulate the proliferation, migration and invasion of cervical cancer by activating the PPAR‐δ pathway.
Qianwei Zhen, Yuexuan Xu, Ying Xu, Xiao Liu, Yuting Zhang, Dan Ye, Sai Han, Shili Liu, Youzhong Zhang   +8 more
wiley   +1 more source

MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis

Advanced Science, EarlyView.
This study uncovers a size‐dependent adhesion paradigm, demonstrating that the glycocalyx protein MUC15 suppresses pancreatic cancer progression by attenuating integrin activation, focal adhesion assembly, and YAP mechanotransduction. Integrating computational modeling and experimental validation, the work reveals a mechanical mechanism by which MUC15 ...
Simei Zhang, Hongyuan Zhu, Zeen Zhu, Shuai Wu, Yiqun Song, Jin Wang, Xinlong Chen, Weikun Qian, Jianpeng Li, Yangyang Yue, Qinhong Xu, Zhiping Ruan, Qing Li, Yaomin Zhu, Tian Jian Lu, Guy M. Genin, Feng Xu, Zheng Wang, Min Lin   +18 more
wiley   +1 more source

The Circadian Transcription Factor CLOCK Modulates Oxidative Stress Resistance via the ACHL–Relish Axis in Drosophila

Advanced Science, EarlyView.
This study identifies the circadian transcription factor CLOCK (CLK) as a key regulator of oxidative stress resistance in fruit flies. CLK controls immune responses by driving rhythmic transcription of an RNA‐binding protein‐Achilles (ACHL) in the fly brain, which post‐transcriptionally represses the NF‐κB homolog Relish, limiting immune activation and
Xu Liu, Jiajia Fang, Dawei Cheng, Wei Luan, Yan Lv, Wen Hu, Lei Pan, Yong Zhang   +7 more
wiley   +1 more source

The High‐Altitude Adaptation Characteristics of Microbiota‐Host Cross‐Talk in Yak Gastrointestinal Track

Advanced Science, EarlyView.
In this study, a single‐cell atlas of 117,019 yak gastrointestinal cells across 54 subtypes identified HNF4A and SREBF2 as key transcription factors targeting MYO6 gene. Cross‐species and multi‐omics analyses reveals epithelial cells as key regulators that, through interactions with microbes, particularly Bacillus, facilitate flexible energy supply and
Chun Huang, Minghao Zhang, Qingbo Zheng, Qinran Yu, Guowu Yang, Wenwen Ren, Xiaoming Ma, Yongfu La, Pengjia Bao, Min Chu, Xian Guo, Chunnian Liang, Ping Yan   +12 more
wiley   +1 more source

Cancer Manipulates Adjacent Adipose Tissue to Exploit Fatty Acids via HIF‐1α/CCL2/PPARα Axis: A Metabolic Circuit to Support Tumor Progression

Advanced Science, EarlyView.
Cancer cells drive adjacent adipose tissue to release fatty acids by secreting CCL2, which activates PPARα‐dependent lipolysis. The resulting fatty acid influx amplifies HIF‐1α/CCL2 signaling, establishing a positive feedback loop that fuels tumor growth.
Jeong‐Eun Yun, Jieun Seo, Jiwon Koh, Seock‐Ah Im, Ki Yong Hong, Yeseon Son, Do‐Won Jeong, Junji Fukuda, Jong‐Wan Park, Yang‐Sook Chun   +9 more
wiley   +1 more source

Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort studies.

BMJ, 2019
Jiao J, Liu G, Shin HJ, Hu FB, Rimm EB, Rexrode KM, Manson JE, Zong G, Sun Q.   +8 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Dietary fat and carcinogenesis

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1999
Epidemiologic investigations have suggested a relationship between dietary fat intake and various types of cancer incidences. Furthermore, epidemiologic studies as well as studies with animal models have demonstrated that not only the amount but also the type of fat consumed is important.
Woutersen, R.A., Appel, M.J., Garderen-Hoetmer, A. van, Wijnands, M.V.W.   +3 more
openaire   +4 more sources

Dietary fats and cancer

Medical Hypotheses, 1985
The mono-unsaturated non-essential fatty acid oleic acid (OA) has been shown to stimulate malignant cell proliferation in culture significantly. In contrast, the essential fatty acids (EFAs) linoleic acid (LA) and alpha-linolenic acid (ALA) and their longer chain metabolic derivatives have been shown to have potent proliferation suppressive effects on ...
I.E. Katzeff, J. Booyens, L Maguire
openaire   +3 more sources