Results 301 to 310 of about 164,007 (344)

Highly Stable Aggregation‐Induced Emission‐Functionalized Histatin1 Coated With Platelet Vesicles for Diabetic Wound Healing

Aggregate, EarlyView.
Diabetic wound healing is blocked by persistent inflammation and oxidative stress. Bioactive substances like growth factors and Hsts promote repair but lack long‐term stability. Herein, a platelet membrane‐coated nanoparticle system (PNP) is proposed to achieve enhanced retention of aggregation‐induced emissive (AIE) molecular‐modified Hst1 (Hst1‐AIE ...
Xiaoxuan Lei, Judun Zheng, Xu Chen, Liwen Liang, Zhuohong Li, Cancan Huang, Minghai Zhao, Gang Wu, Yuhui Liao, Bin Yang   +9 more
wiley   +1 more source

Changes in Types of Dietary Fats Influence Long-term Weight Change in US Women and Men. [PDF]

J Nutr, 2018
Liu X, Li Y, Tobias DK, Wang DD, Manson JE, Willett WC, Hu FB.   +6 more
europepmc   +1 more source

A conceptual model for co‐developing a culturally tailored intervention for Latina immigrant caregivers of children with disabilities

American Journal of Community Psychology, EarlyView.
Abstract The growing diversity of the U.S. population, partly due to immigration, has called attention to scholars and practitioners to attend to immigrants' cultural beliefs, values, and ways of doing when designing interventions to promote health and wellbeing.
Yolanda Suarez‐Balcazar, Amy Pei‐Lung Yu, Stephany Brown, Jasmine Brown‐Hollie, Adriana Crostley, Deborah Parra‐Medina, Mariela Saenz, Mansha Mirza, Aileen Velasquez, Sandra Vanegas, Sandy Magaña   +10 more
wiley   +1 more source

Hypoferremic Response to Chronic Inflammation Is Controlled via the Hemojuvelin/Hepcidin/Ferroportin Axis and Does Not Involve Hepcidin‐Independent Regulation of Fpn mRNA

American Journal of Hematology, EarlyView.
ABSTRACT The iron regulatory hormone hepcidin contributes to the pathogenesis of anemia of inflammation (AI) by inhibiting the iron exporter ferroportin in target cells, causing hypoferremia. Under acute inflammation, hepcidin induction requires hemojuvelin (Hjv), a bone morphogenetic protein co‐receptor, while Fpn mRNA is also suppressed in a hepcidin‐
Siqi Liu, Sofiya Tsyplenkova, Carine Fillebeen, Kostas Pantopoulos   +3 more
wiley   +1 more source

Yunweiling alleviates functional constipation: integrating network pharmacology and experimental study

Animal Models and Experimental Medicine, EarlyView.
In a study combining network pharmacological analysis and experimental verification, yunweiling has been shown improve functional constipation by inhibiting the PI3K‐Akt‐p53 signaling pathway and reducing the expression of TP53. Abstract Background This study investigated the impacts and mechanisms of yunweiling in the management of Functional ...
Peng Zhang, Wei Li, Weiwen Zheng, Jinwen Liu, Nuonan She, Xia Chen, Weibo Wen   +6 more
wiley   +1 more source

Improved husbandry measures to enhance reproducibility of wound healing studies in the Leprdb/db mouse

Animal Models and Experimental Medicine, EarlyView.
Though the Leprdb/db mouse is a common and well‐studied model of type II diabetes mellitus, there are a few specific guidelines for its husbandry, and wound complications are common. We present a modified husbandry approach for the Leprdb/db mouse that includes increased cage size, decreased housing density, and more frequent cage changes.
May Barakat, Brian P. David, Junhe Shi, Angela Xu, Terry W. Moore, Lin Chen, Luisa A. DiPietro   +6 more
wiley   +1 more source

Bifidobacterium animalis subsp. lactis modulates early‐life immune response and gut metabolism

Animal Models and Experimental Medicine, EarlyView.
Background: The maturation of the immune system is critical during early life, as it involves the differentiation, maturation, and establishment of immune tolerance of immune cells. This process is influenced not only by genetic factors but also by environmental factors, particularly the symbiotic microbiota. Bifidobacterium animalis subsp.
Haoming Du, Yiran Cai, Lulu Shen, Yuxing Zheng, Lingling Zhao, Ruibiao Hu, Shan Jiang, Jiajia Yuan, Chengming Hu, Qi Deng, Jiaoyan Huang, Jingbo Hu, Yuexiang Wang, Jing Tan, Jiahui Chen, Feitong Liu, Yuanyuan Duan, Haitao Niu   +17 more
wiley   +1 more source

Longitudinal Metabolomics in Amyotrophic Lateral Sclerosis Implicates Impaired Lipid Metabolism

Annals of Neurology, EarlyView.
Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by altered metabolome and energy homeostasis, manifesting with body mass index changes and hypermetabolism—both prognostic of disease progression and survival.
Kai Guo, Masha G. Savelieff, Dae‐Gyu Jang, Samuel J. Teener, Lili Zhao, Junguk Hur, Stephen A. Goutman, Eva L. Feldman   +7 more
wiley   +1 more source