Results 61 to 70 of about 5,719,188 (264)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The PERSonalized Glucose Optimization Through Nutritional Intervention (PERSON) Study: Rationale, Design and Preliminary Screening Results

Frontiers in Nutrition, 2021
Background: It is well-established that the etiology of type 2 diabetes differs between individuals. Insulin resistance (IR) may develop in different tissues, but the severity of IR may differ in key metabolic organs such as the liver and skeletal muscle.
Anouk Gijbels, Anouk Gijbels, Inez Trouwborst, Inez Trouwborst, Kelly M. Jardon, Kelly M. Jardon, Gabby B. Hul, Els Siebelink, Suzanne M. Bowser, Dilemin Yildiz, Lisa Wanders, Lisa Wanders, Balázs Erdos, Balázs Erdos, Dick H. J. Thijssen, Dick H. J. Thijssen, Edith J. M. Feskens, Gijs H. Goossens, Lydia A. Afman, Ellen E. Blaak, Ellen E. Blaak   +20 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Associations of the insulinemic potential of diet and lifestyle with metabolic dysfunction-associated steatotic liver disease (MASLD) risk in adults with type 2 diabetes

Scientific Reports
Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent among individuals with type 2 diabetes mellitus (T2DM), largely due to shared metabolic risk factors such as insulin resistance and obesity.
Danial Fotros, Ali Jafari, Azita Hekmatdoost, Marieh Salavatizadeh, Hossein Poustchi, Mohammad Ebrahim Khamseh, Zahra Yari   +6 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Dietary and lifestyle factors associated with cardiovascular disease risk: a structural equation modeling approach

BMC Cardiovascular Disorders
Background Cardiovascular diseases (CVDs), resulting from complex interactions among socioeconomic, behavioral, and dietary factors, remain a major global health challenge.
Faramarz Amini, Reza Pakzad, Kourosh Sayehmiri, Asma Salari-Moghaddam, Khairollah Asadollahi, Farhad Moradpour   +5 more
doaj   +1 more source

Associations of dietary sugar and glycemic index with adiposity and insulin dynamics in overweight Latino youth [PDF]

The American Journal of Clinical Nutrition, 2007
Few studies have examined the relation between dietary carbohydrate quality, adiposity, and insulin dynamics in children.The objective of the study was to determine which aspects of dietary carbohydrate, specifically dietary sugar, fiber, glycemic index, or glycemic load, are associated with adiposity and insulin dynamics in overweight Latino children ...
Jaimie N, Davis, Katharine E, Alexander, Emily E, Ventura, Louise A, Kelly, Christianne J, Lane, Courtney E, Byrd-Williams, Claudia M, Toledo-Corral, Chris K, Roberts, Donna, Spruijt-Metz, Marc J, Weigensberg, Michael I, Goran   +10 more
openaire   +2 more sources

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Insulin resistance and its relation to adiposity, cardiorespiratory fitness and dietary intake among Azorean adolescents [PDF]

, 2012
Insulin resistance is an important compo nent in the development of metabolic syndrome and lifestyle-related diseases. The aim of the present study is to investigate the relationship between insulin resistance (IR), adiposity, cardiorespiratory fitness ...
Soares-Miranda, L., Vale, S., Marques, A. I., Santos, P. C., Moreira, C., Abreu, S., Rute, Santos, Mota, J.   +7 more
core   +1 more source