Results 241 to 250 of about 539,375 (309)

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

High-protein diets increase microbiota associated p-cresol production in the colon and reduce gut barrier function in a sex-dependent manner. [PDF]

Eur J Nutr
James D, Batool M, Poveda C, Hayirli Z, Callow C, Abbas M, Linden B, Gibson J, Griffin BA, Elmore JS, Walton GE, Robertson MD, Lewis MC.   +12 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Gut Health Responses to Nutritional Interventions in Paediatric Crohn's Disease, Including the Potential Outcomes of Mucosal Barrier Preservation: A Systematic Review. [PDF]

Nutrients
Marind EC, McCullough F.
europepmc   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Association between dietary patterns and depressive symptoms in Chinese adults. [PDF]

Asia Pac J Clin Nutr
Guo S, Sun X, Huang K, Pan C, Liu X, Wang W, Ning F, Xu J, Li A, Zhang D, Nan H.   +10 more
europepmc   +1 more source

Understanding Food Choices Among University Students: Dietary Identity, Decision-Making Motives, and Contextual Influences. [PDF]

Nutrients
Aboueldahab A, Vanutelli ME, D'Addario M, Steca P.   +3 more
europepmc   +1 more source

Gut Microbiome-Associated Effects of Plant-Based Diets on Glucose Homeostasis, Body Composition, and Cognitive Function: A Scoping Review. [PDF]

Adv Nutr
van Kalkeren CA, Adam TC, Blaak EE.
europepmc   +1 more source

Polyunsaturated Fatty Acid Biosynthesis Across Three Trophic Levels in Freshwater Aquaculture: Current Knowledge and Perspectives. [PDF]

Int J Mol Sci
Ivanova E, Dincheva I, Badjakov I, Georgiev V.   +3 more
europepmc   +1 more source

The multi-target protective effects of quercetin in cerebrovascular diseases: a dietary strategy for endothelial repair and neuroprotection. [PDF]

Front Nutr
Lu T, Gao J, Zhu P, Cao R, Ye K.
europepmc   +1 more source