Results 151 to 160 of about 2,169,476 (341)

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Prediction of 24‐Hour Urinary Sodium Excretion Using Machine‐Learning Algorithms

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Accurate quantification of sodium intake based on self‐reported dietary assessments has been a persistent challenge. We aimed to apply machine‐learning (ML) algorithms to predict 24‐hour urinary sodium excretion from self‐reported ...
Rikuta Hamaya, Molin Wang, Stephen P. Juraschek, Kenneth J. Mukamal, JoAnn E. Manson, Deirdre K. Tobias, Qi Sun, Gary C. Curhan, Walter C. Willett, Eric B. Rimm, Nancy R. Cook   +10 more
doaj   +1 more source

Advanced Dental Composite Technology via Bisilanized Dual‐Action Nanofillers for Biofilm Control

Advanced Science, EarlyView.
A multimodal research strategy has led to the development of an innovative resin‐based composite (RBC) with dual antibacterial action. The S_CM‐RBC formula showed strong antibiofilm activity, excellent mechanical strength, and biosafety. It effectively controlled oral bacteria in prevention of caries recurrence, and maintained pulp health in a rat ...
Chenmin Yao, Line Etiennot, Naiera Zayed, Shengjie Liang, Mehraveh Saghi, Jelle Verdonck, Lingyue Liu, Fei Zhang, Wim Teughels, Cui Huang, Kirsten Van Landuyt, Bart Van Meerbeek   +11 more
wiley   +1 more source

Dietary Sodium in the Development of Renal Hypertension

Experimental Biology and Medicine, 1969
SummaryThe evolution of experimental renal hypertension was studied in rats on a sodium deficient diet (50 mg/kg) as compared to those on the same diet with 0.6% sodium added and also with sham operated controls on the two diets. On the low sodium diet, hypertension emerged more gradually and at 8 weeks, the blood pressure was significantly lower than ...
openaire   +2 more sources

Effects of exercise on l-carnitine and lipid metabolism in African catfish (Clarias gariepinus) fed different dietary l-carnitine and lipid levels

, 2010
African catfish (Clarias gariepinus) were fed four isonitrogenous diets (34 % crude protein), each containing one of two lipid (100 or 180 g/kg) and two l-carnitine (15 or 1000 mg/kg) levels. After 81 d of feeding, thirty-two fish (body weight 32 g) from
Ozorio, R.O.A., Verreth, J.A.J., Ginneken, V.J.T., van, Bessa, R.J.B., Verstegen, M.W.A., van Ginneken, V.J.T., Huisman, E.A.   +6 more
core   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Dietary Sodium Intake and Sweat Sodium Losses in Endurance Athletes

, 2020
Dietary Sodium Intake Compared to Sodium Losses in Endurance Athletes Context: Sweat rate and sodium concentration has been investigated previously for endurance athletes; however, dietary sodium intake has not been researched.
Gotthold, Christina
core  

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

An educational intervention for improving knowledge, attitude, and practice of dietary salt intake among individuals with hypertension in public sector secondary care facilities, Agra, India, 2021

The Journal of Clinical Hypertension
We conducted a pre‐post intervention study to determine knowledge, attitude, and practice toward dietary salt intake before, immediately, and 1‐month after nurse‐led one‐on‐one counseling.
Piyush Jain, Sharan Murali, Quincy Mariam Jacob, Roopa Shivashankar, Arun Srivastava, Bency Joseph, Mohankumar Raju, Manikanda Nesan S, Albertino Damasceno, Prabhdeep Kaur   +9 more
doaj   +1 more source