Results 101 to 110 of about 9,178 (246)

Kinase Inhibitors of Novel Pyridopyrimidinone Candidates: Synthesis and In Vitro Anticancer Properties

Journal of Chemistry, 2019
A new class of pyridopyrimidinone compounds containing different nitrogenous heterocycles were synthesized starting from the key precursor 2-hydrazinyl-5-phenyl-7-(pyridin-3-yl)pyrido[2,3-d]pyrimidin-4(3H)-one via condensation with series of aromatic ...
Nagy M. Khalifa, Mohamed A. Al-Omar, Hamad M. Alkahtani, Ahmed H. Bakheit   +3 more
doaj   +1 more source

Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor [PDF]

, 2013
Established therapy in Alzheimer’s disease involves potentiation of the endogenous orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations in the cortex and hippocampus.
Arthur Christopoulos, Aurelio L., Avlani V. A., Barbosa J., Bell R. P., Ben Capuano, Bunce R. A., Canals M., Cao X., Casara P., Celine Valant, Conn P. J., Decker M., Eaton P. E., Gould R. G., Holden M., Koguro K., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Kuduk S. D., Langmead C. J., Lauer W. M., Leach K., Ma L., Maffioli S. I., Meanwell N. A., Medeiros R. R., Patrick M. Sexton, Peter J. Scammells, Podányi B., Reid P. R., Shailesh N. Mistry, Shirey J. K., Wess J., Wise W. M., Yang F. V., Zewge D., Zhang Y., Škugor M. M.   +43 more
core   +2 more sources

Diethyl 2-(3,4-dicyanophenyl)-2-[(2-naphthyl)methyl]malonate

Acta Crystallographica Section E Structure Reports Online, 2005
The asymmetric unit of the title compound, C26H22N2O4, contains two crystallographically independent mol­ecules. The crystal structure is stabilized by intra- and inter­molecular C—H⋯O inter­actions.
Sener, MK, Yildirim, SO, Kocak, MB, Fun, HK, Akkurt, MEHMET   +4 more
openaire   +3 more sources

Diethyl 2-[(5-methoxy-2-methyl-1-phenylsulfonyl-1H-indol-3-yl)methylene]malonate

Acta Crystallographica Section E, 2009
In the title compound, C24H25NO7S, the sulfonyl-bound phenyl ring is approximately perpendicular to the indole ring system [dihedral angle = 87.72 (5)°].
T. Kavitha, M. Thenmozhi, V. Dhayalan, A. K. Mohanakrishnan, M. N. Ponnuswamy   +4 more
doaj   +1 more source

Lactone Carboxylic Acids. III. Reaction of Ethyl　β-Alkylglycidates with Ethyl Malonate [PDF]

, 1967
The ring opening of epoxide group in the reaction of ethyl ,β-alkylglycidates with sodiomalonate was observed mostly at the α-position of the glycidates.
Kariya, Yosihiro, Takeda, Akira, Torii, Sigeru   +2 more
core   +1 more source

A new purple sulfur bacterium from saline littoral sediments, Thiorhodotvibrio winogradskyi gen. nov. and sp. nov. [PDF]

, 1992
Two strains of a new purple sulfur bacterium were isolated in pure culture from the littoral sediment of a saline lake (Mahoney Lake, Canada) and a marine microbial mat from the North Sea island of Mellum, respectively.
BB Jørgensen, BB Jørgensen, C Kämpf, CLM Steenbergen, E Reynolds, E Siefert, EF Hartree, GA Horridge, GW Luther, H Gemerden van, J Overmann, JAM Nicholson, K Schmidt, M Meshbah, M Takahashi, N Pfennig, N Pfennig, N Pfennig, N Pfennig, PT Visscher, R Wit De, R Wit de, RM Cole, TB Parkin, TW Goodwin, W Bavendamm   +25 more
core   +1 more source

Synthesis of carbon-13-labeled tetradecanoic acids.

Journal of Lipid Research, 1983
The synthesis of tetradecanoic acid enriched with 13C at carbons 1, 3, or 6 is described. The label at the carbonyl carbon was introduced by treating 1-bromotridecane with K13CN (90% enriched) to form the 13C-labeled nitrile, which upon hydrolysis ...
J T Sparrow, K M Patel, J D Morrisett
doaj   +1 more source

Ring transformations in reactions of pyrimidine and N-alkylpyrimidinium salts with nucleophile [PDF]

Paper IOn treatment with liquid ammonia at -33°C, the quaternary pyrimidinium salts, i.e. 1-methylpyrimidinium methyl sulfate, 1,2-dimethylpyrimidinium iodide, 1,4,6-trimethyl-pyrimidinium iodide and 1,2,4,6-tetramethylpyrimidinium iodide demethylate ...
Oostveen, E.A.
core   +1 more source

The Reactions of Ester with Acyl Chloride in the Presence of Aluminum Chloride. V. Reaction Mechanism of the Benzoylation of Diethyl Malonate [PDF]

, 1962
Hiroo Kaneyuki
openalex   +1 more source

Synthesis and characterization of new diiodocoumarin derivatives with promising antimicrobial activities

Beilstein Journal of Organic Chemistry, 2011
A series of 6,8-diiodocoumarin-3-N-carboxamides (4–11) were prepared. Treatment of ethyl 6,8-diiodocoumarin-3-carboxylate (1) with ethyl cyanoacetate/NH4OAc gave ethyl 2-(3-carbamoyl-6,8-diiodocoumarin-4-yl)-2-cyanoacetate (12) and 2-amino-4-hydroxy-7,9 ...
Hany M. Mohamed, Ashraf H. F. Abd EL-Wahab, Ahmed M. EL-Agrody, Ahmed H. Bedair, Fathy A. Eid, Mostafa M. Khafagy, Kamal A. Abd-EL-Rehem   +6 more
doaj   +1 more source