Taming tosyl azide: the development of a scalable continuous diazo transfer process [PDF]
, 2016 Heat and shock sensitive tosyl azide was generated and used on demand in a telescoped diazo transfer process. Small quantities of tosyl azide were accessed in a one pot batch procedure using shelf stable, readily available reagents. For large scale diazo
Collins, SG +5 more
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On the ordeal of quinolone preparation via cyclisation of aryl-enamines; synthesis and structure of ethyl 6-methyl-7-iodo-4-(3-iodo-4-methylphenoxy)-quinoline-3-carboxylate [PDF]
, 2017 Recent studies directed to the design of compounds targeting the bc(1) protein complex of Plasmodium falciparum, the parasite responsible for most lethal cases of malaria, identified quinolones (4-oxo-quinolines) with low nanomolar inhibitory activity ...
Bras, Elisa M. +8 more
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Synthesis and Antimicrobial Activity of Novel Substituted Ethyl 2-(Quinolin-4-yl)-propanoates
Molecules, 2013 Substituted 4-hydroxyquinolines were synthesized from anilines and diethyl 2-(ethoxymethylene)malonate by the Gould-Jacobs reaction via cyclization of the intermediate anilinomethylenemalonate followed by hydrolysis and decarboxylation.
Yong Zhou +3 more
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Diethyl 2-[(4-bromoanilino)methylidene]malonate
Acta Crystallographica Section E, 2010 In the title compound, C14H16BrNO4, intermolecular C—H...O hydrogen bonds link the molecules, forming a stable structure. An intramolecular N—H...O hydrogen bond results in the formation of a six-membered ring and helps to establish ...
Huai-Qing Wang +4 more
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Latent olefin metathesis catalysts [PDF]
, 2009 Olefin metathesis is a versatile synthetic tool for the redistribution of alkylidene fragments at carbon-carbon double bonds. This field, and more specifically the development of task-specific, latent catalysts, attracts emerging industrial and academic ...
Drozdzak, Renata +4 more
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Synthesis and Characterisation of Various Diester and Triester Adducts of TiCl4 [PDF]
, 2015 Titanium(IV) chloride and the triester glycerol tribenzoate (gtb) were reacted under moisture-free conditions in order to investigate the use of triester-containing oils in the purification of TiCl4 in industrial processes. This resulted in the isolation
Blackburn, BJ +6 more
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Interrupted Carbonyl‐Alkyne Metathesis [PDF]
, 2020 Carbonyl‐olefin metathesis and carbonyl‐alkyne metathesis represent established reactivity modes between carbonyls, alkenes, and alkynes under Lewis and Brønsted acid catalysis.
McFarlin, Austin T. +3 more
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Ethyl (1,3-diphenyl-1H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)acetate
Molbank, 2011 Novel ethyl (1,3-diphenyl-1H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)acetate (5), was prepared via heating of 5-amino-1,3-diphenyl-4,5-dihydro-4-imino-1H-pyrazolo[3,4-d] pyrimidine (1) and diethyl malonate (2) under reflux.
Sobhi M. Gomha, Thoraya A. Farghaly
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Beilstein Journal of Organic Chemistry, 2012 A new guanidine-thiourea organocatalyst has been developed and applied as bifunctional organocatalyst in the Michael addition reaction of diethyl malonate to trans-β-nitrostyrene.
Tatyana E. Shubina +4 more
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An efficient [bmim]oh catalysed the condensations of aromatic aldehydes and diethyl malonate
Vietnam Journal of Science, Technology and Engineering, 2018 The rapid and green procedure for the Knoevenagel reaction between aromatic aldehydes and diethyl malonate was developed by using 1-butyl-3- methylimidazolium hydroxide, [Bmim]OH, as an efficient catalyst.
Thi Thuy Duy Nguyen, Hoang Phuong Tran
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