Results 61 to 70 of about 8,721 (248)

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, EarlyView.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

Nanoporous aluminosilicate-catalyzed telescoped acetalization-direct aldol reactions of acetals with 1,3-dicarbonyl compounds [PDF]

, 2018
Nanoporous aluminosilicate materials, synthesized by an evaporation-induced self-assembly process, catalyze the direct aldol reaction of acyclic acetals with a range of 1,3-dicarbonyl compounds to produce the corresponding aldol addition products in high
Davies, Thomas Edward, Graham, Andrew Edward, Taylor, Stuart Hamilton   +2 more
core   +4 more sources

Reversibly Cross‐Linked Polyamide 6 Using 1‐(5‐(Aminoethyl)‐2‐nitrophenyl)Ethanol as Photolabile Cross‐Linker

Macromolecular Materials and Engineering, EarlyView.
This exploratory study investigates the reversible cross‐linking of polyamide 6 by the photolabile cross‐linker 1‐(5‐(Aminoethyl)‐2‐nitrophenyl)ethanol (PXL). The storage modulus of the material increases with increasing PXL content and decreases when the exposure time of the samples is increased.
Florian Puch, Anthony Fink, Michel Schlosser, Thomas Welzel, Robert Geitner   +4 more
wiley   +1 more source

Facile and Practical Synthesis of Substituted Piperidine‐2,6‐Diones Under Transition‐Metal Free Condition

ChemistryOpen, EarlyView.
KOtBu‐promoted facile and practical synthesis of various substituted piperidine‐2,6‐diones between methyl acetates and acrylamides via a Michael addition/intramolecular imidation cascade sequence has been disclosed. And reaction scale‐up, further transformation of representative products, and preparation of bioactive molecules (e. g.
Yue‐Hua Liu, Zhang‐Qin Xue, Kai‐Wen Yang, Hao‐Wen Yin, Bo Yang, Rui Zhang, Hao Zhong, Zhu‐Shuang Bai   +7 more
wiley   +1 more source

Benzamide‐Directed Hydroarylative Cross‐Couplings Using Minimally Activated Alkenes: Enantioselective Synthesis of Tertiary and Quaternary Stereocenters

Angewandte Chemie, Volume 137, Issue 22, May 26, 2025.
Benzamide‐directed iridium‐catalyzed branched selective and enantioselective C(sp2)‐H additions to minimally activated alkenes give tertiary and quaternary benzylic stereocenters under byproduct‐free conditions. The processes are enabled by a family of SPINOL‐based homochiral diphosphonite ligands.
Timothy P. Aldhous, Raymond Chung, Abbas Hassan, Andrew G. Dalling, Phillippa Cooper, Simon Grélaud, Richard J. Mudd, Lyman J. Feron, Paul D. Kemmitt, John F. Bower   +9 more
wiley   +2 more sources

Enantioselective Synthesis of Dialkylated N-Heterocycles by Palladium-Catalyzed Allylic Alkylation [PDF]

, 2015
The enantioselective synthesis of α-disubstituted N-heterocyclic carbonyl compounds has been accomplished using palladium-catalyzed allylic alkylation.
Houk, K. N., Jiménez-Osés, Gonzalo, Numajiri, Yoshitaka, Stoltz, Brian M., Wang, Bo   +4 more
core   +2 more sources

Recyclable Ligand‐Free Cobalt Catalyst for Alkoxycarbonylation of Chloroacetates

ChemSusChem, Volume 18, Issue 17, September 1, 2025.
The first recyclable homogeneous catalyst based on ligand‐free cobalt carbonyls for alkoxycarbonylation is reported here. Using the inexpensive precursor CoCO3, this system is shown to yield up to 99% alkoxycarbonylation of the C(sp3)Cl bond with nearly 100% selectivity.
Wenyu Wang, Zhusong Cao, Yuya Hu, Rui Sang, Qingshan Kong, Qicai Xue, Baoxin Zhang   +6 more
wiley   +1 more source

Mn-mediated sequential three-component domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction towards annulated imidazo[1,2-a]pyridines

Beilstein Journal of Organic Chemistry, 2018
The sequential three-component reaction between o-hydroxybenzaldehydes, N-(cyanomethyl)pyridinium salts and a nucleophile towards substituted chromenoimidazopyridines under oxidative conditions has been developed. The employment of Mn(OAc)3·2H2O or KMnO4
Olga A. Storozhenko, Alexey A. Festa, Delphine R. Bella Ndoutoume, Alexander V. Aksenov, Alexey V. Varlamov, Leonid G. Voskressensky   +5 more
doaj   +1 more source

Addition-substitution reactions of 2-thio-3-chloroacrylamides with carbon, nitrogen, oxygen, sulfur and selenium nucleophiles [PDF]

, 2011
Synthetically versatile conjugate addition of a range of carbon, nitrogen, oxygen, sulfur and selenium nucleophiles to the highly functionalised 2-thio-3-chloroacrylamides is described.
Chopra, Jay, Collins, Stuart G., Kissane, Marie, Lawrence, Simon E., Maguire, Anita R., Murphy, Linda., Murphy, Maureen, O'Brien, Elisabeth   +7 more
core   +1 more source

Decarboxylative Michael Additions of Substituted Malonic Acid Half‐Oxyesters to Methylidene Malonates

European Journal of Organic Chemistry, Volume 28, Issue 30, August 19, 2025.
Substituted malonic acid half oxyesters reacted with alkylidene malonates in a fast, efficient decarboxylative Michael addition, delivering adducts in high yields. The reaction occurred in bulk solvent, open to air, needing only a weak amine base as an organocatalyst to drive a mechanism involving addition prior to decarboxylation.
Marine Pinaud, Tania Xavier, Léa Lin, Erwan Le Gall, Marc Presset   +4 more
wiley   +1 more source