Results 11 to 20 of about 328,615 (242)

Diethylcarbamazine elicits calcium signals by activation of Brugia malayi TRP-2b channels heterologously expressed in HEK293 cells [PDF]

Scientific Reports
Diethylcarbamazine is a classic anthelmintic that is used for the prevention and treatment of lymphatic filariasis. The mode of action of diethylcarbamazine is still not well understood with the consensus that it acts on the host immune system, rather ...
Paul D. E. Williams, Sudhanva S. Kashyap, Alan P. Robertson, Richard J. Martin   +3 more
doaj   +2 more sources

Antifilarial treatment strategies: a systematic review and network meta-analysis [PDF]

BMC Infectious Diseases
Background The World Health Organization (WHO) prescribes mass drug administration (MDA) to eradicate lymphatic filariasis within endemic populations.
Muayad Saud Albadrani, Amr Molla, Hossein M. Elbadawy, Heba M Eltahir, Shyamkumar Sriram, Mekky M Abouzied, Eman Mohamed Sharaf Elsayed   +6 more
doaj   +2 more sources

Development of diethylcarbamazine-loaded poly(caprolactone) nanoparticles for anti-inflammatory purpose: Preparation and characterization [PDF]

Brazilian Journal of Pharmaceutical Sciences, 2022
Diethylcarbamazine-loaded nanoparticles were previously evaluated for their anti-inflammatory activity. However, little is known regarding their physicochemical properties.
Henrique Rodrigues Marcelino, Brennda Martins Gabinio, Marine Nascimento de Lima, Silvana Cartaxo da Costa Urtiga, Gabriel Barros Rodrigues, Bruna Braga Dantas, Demétrius Antônio Machado de Araújo, Christina Alves Peixoto, Elquio Eleamen Oliveira   +8 more
doaj   +2 more sources

Diagnosis of O. volvulus infection via skin exposure to diethylcarbamazine: clinical evaluation of a transdermal delivery technology-based patch [PDF]

Parasites & Vectors, 2015
Background Elimination of onchocerciasis in Africa is now regarded as an achievable goal in many areas. This makes monitoring changes in infection prevalence a key component of control programmes. Monitoring is currently based on determining the presence
K. Awadzi, Nicholas O. Opoku, Simon K. Attah, Janis K. Lazdins-Helds, Annette C. Kuesel   +4 more
doaj   +2 more sources

Diethylcarbamazine (Hetrazan) in Experimental Trichinosis [PDF]

The American Journal of Tropical Medicine and Hygiene, 1952
The general acceptance of diethylcarbamazine or Hetrazan (1-diethylcarbamyl-4-methylpiperazine hydrochloride [or dihydrogen citrate]) as a useful drug in the treatment of filarial diseases caused by several types of worm and affecting various animals, including man, has stimulated its trial in treatment of other nematode infections. It has been claimed
T B, MAGATH, J H, THOMPSON
openaire   +3 more sources

Treatment of loiasis: a review of clinical management recommendations [PDF]

Infectious Diseases of Poverty
Background Loiasis affects more than 20 million residents of endemic regions in Central and West Africa causing chronic and often lifelong disease. Antifilarial treatment options for loiasis include diethylcarbamazine, ivermectin, and albendazole.
Dorothea Ekoka Mbassi, Rike Dreeßen, Rella Zoleko Manego, Saskia Dede Davi, Tamara Nordmann, Johannes Mischlinger, Michael Ramharter   +6 more
doaj   +2 more sources

Coverage evaluation of mass drug administration for lymphatic filariasis in four endemic districts of Jharkhand, India [PDF]

Journal of Health, Population and Nutrition
Background Lymphatic filariasis (LF) remains endemic in several districts of Jharkhand despite repeated Mass Drug Administration (MDA) rounds. This study assessed drug coverage, compliance, and associated factors in four endemic districts: Deoghar, Dumka,
Bijit Biswas, G. Jahnavi, Pratima Gupta, Abhishek Paul, Saurabh Varshney   +4 more
doaj   +2 more sources

Diethylcarbamazine and Non-Diethylcarbamazine Related Bancroftian Granuloma: An Immunohistochemical Study of Eosinophil Toxic Proteins [PDF]

International Journal of Biomedical Science, 2010
It has been suggested, mostly using in vitro experiments, that defenses against parasites involve mainly activated eosinophils and their toxic proteins, such as major basic protein (MBP), eosinophil cationic protein (ECP) and eosinophil peroxidase (EPO).
Jose, Figueredo-Silva, Carmelita, Cavalcanti, Luciano Tavares, Montenegro, Joaquim, Norões, Gerusa, Dreyer   +4 more
openaire   +3 more sources

A low-tech analytical method for diethylcarbamazine citrate in medicated salt. [PDF]

PLoS Neglected Tropical Diseases, 2011
The World Health Organization has called for an effort to eliminate Lymphatic Filariasis (LF) around the world. In regions where the disease is endemic, local production and distribution of medicated salt dosed with diethylcarbamazine (DEC) has been an ...
Abigail Weaver, Patrick Brown, Shannon Huey, Marco Magallon, E Brennan Bollman, Dominique Mares, Thomas G Streit, Marya Lieberman   +7 more
doaj   +3 more sources

Effects of rifampicin and ketoconazole on the pharmacokinetics of a single oral dose of diethylcarbamazine in healthy volunteers

Journal of Health Science and Medical Research (JHSMR), 2006
Diethylcarbamazine (DEC) is the first-line drug for the control and treatment of lymphatic filariasis caused by the Wuchereria bancrofti and Brugia malayi parasite. DEC is rapidly and extensively metabolised in the liver.
W Ridtitid, M Wongnawa, W Mahatthanatrakul, A Pattanawongsa, N Bumrungwong, M Sunbhanich   +5 more
doaj   +2 more sources