Results 201 to 210 of about 20,408 (237)
Some of the next articles are maybe not open access.
Diethylcarbamazine (Hetrazan) in Experimental Trichinosis
The American Journal of Tropical Medicine and Hygiene, 1952The general acceptance of diethylcarbamazine or Hetrazan (1-diethylcarbamyl-4-methylpiperazine hydrochloride [or dihydrogen citrate]) as a useful drug in the treatment of filarial diseases caused by several types of worm and affecting various animals, including man, has stimulated its trial in treatment of other nematode infections. It has been claimed
John H. Thompson, Thomas B. Magath
openaire +3 more sources
Diethylcarbamazine: A Leukotriene Inhibitor
International Journal of Microcirculation, 1994Sepsis is associated with alterations in microcirculatory flow which is demonstrated by impaired (O2 delivery and extraction by the peripheral tissues. Leukotrienes, derivatives of arachidonic acid, have been implicated as mediators of the septic process.
R. Dunn, A. Barrett, F.B. Rogers
openaire +2 more sources
Onchocerciasis treated with diethylcarbamazine
British Journal of Dermatology, 1977One hundred patients with onchocerciasis were treated with diethylcarbamazine: a single course of treatment led to clinical cure in 48% of the patients; no means of anticipating which patients might require only a single course of treatment was found.
openaire +3 more sources
Analysis of diethylcarbamazine and diethylcarbamazine-N-oxide by gas chromatography
Archives of Pharmacal Research, 1996Diethylcarbamazine (DEC, 1-diethylcarbamyl-4-methylpiperazine) is an antiparasitic piperazine derivative used in the treatment of lymphatic filariasis caused byWuchereria bancrofti, Brugia malayi orBrugia timori. DEC-N-oxide is a major metabolite in humans and has antifilarial activity.
openaire +2 more sources
Topical diethylcarbamazine in ocular onchocerciasis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1973Abstract 1. 1. The effects of 3% diethylcarbamazine eye drops (Onchozan) on O. volvulus microfilariae in the cornea and in the anterior chamber are described in 9 Cameroonian subjects. 2. 2. The therapy tended to reduce the numbers of microfilariae seen in the anterior chamber, but they were not completely eliminated.
John R. Anderson, Harald Fuglsang
openaire +3 more sources
COMPARISON OF FLUBENDAZOLE AND DIETHYLCARBAMAZINE IN TREATMENT OF ONCHOCERCIASIS
The Lancet, 1983Flubendazole, an injectable benzimidazole drug, was compared with diethylcarbamazine (DEC) in a prospective double-blind study of the treatment of onchocerciasis. Nineteen Mexican men were randomly assigned to receive either flubendazole 750 mg intramuscularly once a week for 5 doses, or DEC 100 mg twice daily for 14 days, and they were then followed ...
F. Beltran-Hernandez +13 more
openaire +3 more sources
Effect of Diethylcarbamazine on the Alveolitis of Tropical Eosinophilia
Respiration, 1991Bronchoalveolar lavage studies in 33 patients with acute untreated tropical eosinophilia have demonstrated intense eosinophilic alveolitis. Following treatment with a standard 3-week course of diethylcarbamazine, there was a significant fall in lung eosinophils (p less than 0.001).
Vijayan, V K +3 more
openaire +3 more sources
Evidence of Nonsusceptibihty to Diethylcarbamazine in Wucheria bancrofti
Journal of Infectious Diseases, 1991This study assessed Wuchereria bancrofti-infected patients who received diethylcarbamazine (DEC) to determined if drug levels were comparable between individuals who continued to harbor circulating microfilariae and those whose blood became clear of parasites, between those with high and low microfilaria counts, and between infected and noninfected ...
Patrick J. Lammie +3 more
openaire +3 more sources
Topical Diethylcarbamazine in the Treatment of Ocular Onchocerciasis
The American Journal of Tropical Medicine and Hygiene, 1970Abstract An ophthalmic preparation of diethylcarbamazine may be a useful addition to presently available methods of treating onchocerciasis. Studies in animals showed good penetration of such a preparation into the anterior segment of the eye, that portion that is most commonly affected by the disease.
Irving H. Leopold +2 more
openaire +3 more sources
Anti-inflammatory effects of diethylcarbamazine: A review
European Journal of Pharmacology, 2014Diethylcarbamazine (DEC) interferes with cyclooxygenase and lipoxygenase pathways, reducing the production of thromboxane, prostacyclin, prostaglandin and leukotrienes. Recent studies using different experimental models of inflammation have indicated that DEC, in addition to inhibiting cyclooxygenase and lipoxygenase pathways, also inhibits nuclear ...
Christina Alves Peixoto +1 more
openaire +3 more sources