Results 211 to 220 of about 20,408 (237)

Morphological changes in the testis induced by diethylcarbamazine

Reproductive Toxicology, 2006
Diethylcarbamazine (DEC) had been proved to be highly effective against lymphatic filariasis, however its effect on vertebrate cells remains uncertain. After 12 days treatment with DEC, most of the Leydig cells were hypertrophied with several lipid droplets, and others had no nucleus and presented characteristic steatosis features.
Valdemiro Amaro da Silva Junior, Elisângela Santos Ferreira Dias, Karina L.A. Saraiva, Christina Alves Peixoto   +3 more
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Genotoxic potential of diethylcarbamazine, an antifilarial drug

Toxicology Letters, 1988
The mutagenic potential of diethylcarbamazine (DEC) was evaluated by metaphase chromosome analysis and the micronucleus test in bone marrow cells of mice. Both assay systems revealed clastogenicity, although not severe. The time-response study of metaphase chromosomes exhibited an early effect; at 72 h post-treatment the effect came down to the control
B. Roy, R.K. Das
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Comparison of Ivermectin and Diethylcarbamazine in the Treatment of Onchocerciasis

New England Journal of Medicine, 1985
We compared ivermectin with diethylcarbamazine for the treatment of onchocerciasis in a double-blind, placebo-controlled trial. Thirty men with moderate to heavy infection and ocular involvement were randomly assigned to receive ivermectin in a single oral dose (200 micrograms per kilogram of body weight), diethylcarbamazine daily for eight days, or ...
Bruce M. Greene, Hugh R. Taylor, Eddie W. Cupp, Robert P. Murphy, Albert T. White, Mohammed A. Aziz, Hartwig Schulz-Key, Salvatore A. D'Anna, Henry S. Newland, Leonard P. Goldschmidt, Cheryl Auer, Aloysius P. Hanson, S. Vaanii Freeman, Earl W. Reber, P. Noel Williams   +14 more
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Immunoadjuvant effect of diethylcarbamazine in experimental filariasis

International Immunopharmacology, 2015
Lymphatic filariasis caused by tissue dwelling nematodes is endemic in 73 countries and drugs have been administered to control or stop the infection. Resurgence of the infection after mass drug administration necessitates the study of several parasite antigens or adjuvants for vaccine developments. In this study, diethylcarbamazine (DEC) was evaluated
Kaliraj Perumal, Anugraha Gandhirajan, Prince R. Prabhu, Jeya Prita Parasurama Jawaharlal, Nithya Krishnan   +4 more
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Platelets mediate the action of diethylcarbamazine on microfilariae

Nature, 1987
More than 400 million people in the world are infected by filarial parasites leading to a wide range of pathologies. Although introduced in 1947, the mainstay of the therapy and control of the filariases is diethylcarbamazine (N,N-diethyl-4-methyl-1-piperazine carboxamide; DEC), the mode of action of which still remains unknown despite widespread use ...
Henri Taelman, Michel Lagarde, Boris Vargaftig, Pierre Braquet, Joël Pincemail, André Capron, Michel Joseph, Jean-Yves Cesbron   +7 more
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Diethylcarbamazine in ascariasis [PDF]

The Indian Journal of Pediatrics, 1953
N. G. Mojumdar, B. Biswas
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In vivo suppression of delayed hypersensitivity by thiabendazole and diethylcarbamazine

Immunopharmacology, 1981
Several anthelminthic agents, such as niridazole and metronidazole, have been demonstrated to have striking effects on the immune system, apparently independent of their antiparasitic activities. In the present study, we have examined the effect of thiabendazole and diethylcarbamazine on two parameters of delayed hypersensitivity, lung granuloma ...
Erik L. Hewlett, Juanita Ruffier, Adel A. F. Mahmoud, Osama Y. Hamid   +3 more
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Diethylcarbamazine Salt in the Control of Lymphatic Filariasis

The American Journal of Tropical Medicine and Hygiene, 1994
Where lymphatic filariasis has diminished since about the 1950s, it has most frequently, though not always, been a direct result of chemotherapeutic intervention against the parasite. Diethylcarbamazine (DEC), a well-established drug, has been the single agent of chemotherapeutic control and has been successful in a wide variety of regimens. This paper
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Diethylcarbamazine and New Compounds for the Treatment of Filariasis

1979
Publisher Summary This chapter discusses the diethylcarbamatine and new compounds for the treatment of filariasis. Diethylcarbamazine is 1-diethylcarbamyl-4-methylpiperazine; it is also known as Hetrazan, Banocide, Notezine, Caricide, Carbilazine, Supatonin, and R.P. 3799.
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The treatment of ascariasis and ancylostomiasis with hetrazan (diethylcarbamazine)

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1954
Abstract The encouraging results obtained by Hewitt et al. (1948) in the treatment of canine ascariasis with hetrazan formed the basis of its trial in human beings. Oliver Gonzales et al. (1949) treated six patients with favourable results giving 2 mg. per kg. body weight three times daily for 24 hours, and followed 8 hours later by a purge.
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