Results 151 to 160 of about 12,555 (220)

Phytochemicals, antioxidant activity and hepatoprotective effect of ginger (Zingiber officinale) on diethylnitrosamine toxicity in rats

Biomarkers, 2019
Context: Chronic liver damage has serious medical consequences. Objective: To investigate the hepatoprotective effect of dry Zingiber officinale (ginger) and its essential (volatile) oil against diethylnitrosamine (DEN) toxicity in rats.
Mariam Abdur-Rahman, Abdelgawad Fahmi, Engy Shams-Eldin   +2 more
exaly   +2 more sources

Mouse Model of Diethylnitrosamine-Induced Gastric Cancer

Journal of Surgical Research, 2008
Nitrosamines are associated with the potential to induce cancer in the digestive tract. Ethanol has also been shown to enhance the effects of nitrosamine-induced carcinogenesis. The aim of this study was to investigate a murine model of the prevalence and types of epithelial lesions induced in the stomach by diethylnitrosamine (DEN), and to evaluate ...
Richard Gurski, Maria Isabel Edelweiss
exaly   +3 more sources

Augmentation of diethylnitrosamine–induced early stages of rat hepatocarcinogenesis by 1,2-dimethylhydrazine

Drug and Chemical Toxicology, 2019
Rawiwan Wongpoomchai, Kanokwan Jarukamjorn, Teera Chewonarin   +2 more
exaly   +2 more sources

Liver Carcinogenesis by Diethylnitrosamine in the Rat

Science, 1966
Diethylnitrosamine was continuously administered to rats at a dose rate of low toxicity. Ninety-two percent of the animals died with multicentrical hepatocellular carcinomata within a narrow and highly reproducible time interval. Discontinuing the carcinogen during the experiment resulted in a prolonged median time until death, a reduced tumor yield ...
Rajewsky, M., Dauber, W., Frankenberg, H.   +2 more
openaire   +3 more sources

Studies on the Metabolism of Diethylnitrosamine in the Rat

Biochemical Society Transactions, 1975
benzopyrene or phenobarbital was used in each case before adding an NADPHregenerating system and either microsomal or soluble fraction from avocado pear. The normal activities obtainable in the ‘microsomal’ and soluble fractions from avocado pear are illustrated in Table I .
J C, Phillips, B G, Lake, M J, Minski, S D, Gangolli, A G, Lloyd   +4 more
openaire   +2 more sources

Occurrence of diethylnitrosamine in some samples of food

Food and Cosmetics Toxicology, 1968
Summary The presence of diethylnitrosamine has been confirmed by thin-layer chromatography in some samples of wheat plant, wheat grain, wheat flour, milk and cheese.
L, Hedler, P, Marquardt
openaire   +2 more sources

Carcinogenesis in different animal species by diethylnitrosamine

Experientia, 1967
Die hepato-cancerogene Wirkung von Diathylnitrosamin konnte an 11 verschiedenen Tierarten in chronisch-toxikologischen Untersuchungen nachgewiesen werden. Die zur Krebserzeugung benotigten Gesamtdosen liegen bei allen Tierarten in der gleichen Grossenordnung.
D, Schmähl, H, Osswald
openaire   +2 more sources

Carcinogenicity of diethylnitrosamine in vitamin‐A‐deficient mice

International Journal of Cancer, 1987
AbstractThe effect of suboptimal levels of dietary vitamin A on diethylnitrosamine (DEN) carcinogenesis was studied in BALB/c and Swiss mice. Two different dietary regimens were employed to induce vitamin A deficiency and DEN was administered by gavage at 2 dose levels: 0.6 mg/kg as a single dose and 200 mg/kg in 4 divided doses.
U, Santhanam, V S, Lalitha, S V, Bhide
openaire   +2 more sources

Anticancer effect of propranolol on diethylnitrosamine‐induced hepatocellular carcinoma rat model

Fundamental & Clinical Pharmacology
Hepatocellular carcinoma (HCC) is the most widespread type of primary liver cancer. Diethylnitrosamine (DEN), a hepatotoxic hepatocarcinogenic compound, is used to induce HCC in animal models.
Yomna M. Tamim, Ahmed A Nagy, Ahmed M. Abdellah, Ahmed H. Osman, Amel F M Ismail   +4 more
semanticscholar   +1 more source

Quercetin and naringenin abate diethylnitrosamine/acetylaminofluorene-induced hepatocarcinogenesis in Wistar rats: the roles of oxidative stress, inflammation and cell apoptosis

Drug and chemical toxicology (New York, N.Y. 1978), 2019
This study was designed to assess the preventive effects and to suggest the probable mechanisms of action of quercetin and naringein in diethylnitrosamine (DEN)/2-acetylaminofluorene (2AAF)-induced hepatocarcinogenesis in Wistar male rats.
O. Ahmed, Adel A. Ahmed, H. Fahim, Mohamed Y. Zaky   +3 more
semanticscholar   +1 more source