Results 101 to 110 of about 844,096 (267)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Eventually periodic solutions of a max-type difference equation. [PDF]

ScientificWorldJournal, 2014
Sun T, Liu J, He Q, Liu XH, Tao C.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Beverton-Holt q-difference equation. [PDF]

J Biol Dyn, 2013
Bohner M, Chieochan R.
europepmc   +1 more source

High order compact finite difference schemes for a nonlinear Black-Scholes equation [PDF]

A nonlinear Black-Scholes equation which models transaction costs arising in the hedging of portfolios is discretized semi-implicitly using high order compact finite difference schemes. In particular, the compact schemes of Rigal are generalized.
Michel Fournié, Ansgar Jüngel, Bertram Düring   +2 more
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Global dynamics of certain homogeneous second-order quadratic fractional difference equation. [PDF]

ScientificWorldJournal, 2013
Garić-Demirović M, Kulenović MR, Nurkanović M.   +2 more
europepmc   +1 more source

Asymptotic properties of the solutions of the second order difference equation [PDF]

, 1998
summary:Asymptotic properties of the solutions of the second order nonlinear difference equation (with perturbed arguments) of the form \[ \Delta ^2 x_n = a_n \varphi (x_{n+k}) \] are ...
Migda, Janusz, Migda, Małgorzata
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

LYNESS DIFFERENCE EQUATION

, 2020
Bakalaura darbā tiek apskatīts klasiskais Lyness diferenču vienādojums: x_(n+1)=(x_n+a)/x_(n-1) , n=0,1,… . Formulētas tās definīcijas un teorēmas no diferenču vienādojumu teorijas, kas nepieciešamas, lai analizētu minēto diferenču vienādojumu.
Džeriņa, Ieva
core