Results 101 to 110 of about 4,949,896 (284)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Finite difference method for time-space-fractional Schrödinger equation

, 2015
In this paper, an implicit finite difference scheme for the nonlinear time-space-fractional Schrödinger equation is presented. It is shown that the implicit scheme is unconditionally stable with experimental convergence order of O(τ2−α+h2), where τ and h
Li, C., Liu, Q., Zeng, F.
core   +1 more source

DIFFERENCE EQUATION FOR AUSTRALIAN SHEEP BLOWFLIES GROWTH

Barekeng
The population of Australian sheep blowflies, Lucilia cuprina, in Australia is of concern to many researchers because it causes several problems. These problems occur in the sheep industry where there is a term "flystrike" in the industry. Flystrike is a
J I Gisbtarani, M N Huda, H Setiyaningsih, Solikhatun Solikhatun   +3 more
doaj   +1 more source

Conservative Difference Scheme for Generalized Rosenau-KdV Equation

Advances in Mathematical Physics, 2014
A conservative Crank-Nicolson finite difference scheme for the initial-boundary value problem of generalized Rosenau-KdV equation is proposed. The difference scheme shows a discrete analogue of the main conservation law associated to the equation. On the
Yan Luo, Youcai Xu, Minfu Feng
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

FOURTH-ORDER AND OPTIMISED FINITE DIFFERENCE SCHEMES FOR THE 2-D WAVE EQUATION [PDF]

, 2013
This paper investigates some fourth-order accurate explicit finitedifference schemes for the 2-D wave equation obtained using 13-,17-, 21-, and 25-point discrete Laplacians.
Bilbao, Stefan, Hamilton, Brian
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A perturbational h4 exponential finite-difference scheme for the convective diffusion equation

, 1993
A perturbational h4 compact exponential finite difference scheme with diagonally dominant coefficient matrix and upwind effect is developed for the convective diffusion equation.
Yang ZF, Chen GQ, Gao Z, CHEN, GQ (reprint author), CHINESE ACAD SCI,INST MECH,BEIJING 100080,PEOPLES R CHINA.   +3 more
core   +1 more source

A different Equator

International Journal of Pharmacy Practice, 2015
Christine, Bond, Sally, Hopewell
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source