Multi-scale times and modes of fast and slow relaxation in solutions with coexisting spherical and cylindrical micelles according to the difference Becker-Döring kinetic equations [PDF]
, 2014 I. A. Babintsev +2 more
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Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Asymptotically almost periodic mild solutions to a class of Weyl-like fractional difference equations [PDF]
, 2019 Junfei Cao, Bessem Samet, Yong Zhou
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Global Stability of a Rational Difference Equation
Discrete Dynamics in Nature and Society, 2010 We consider the higher-order nonlinear difference equation 𝑥𝑛+1=(𝑝+𝑞𝑥𝑛−𝑘)/(1+𝑥𝑛+𝑟𝑥𝑛−𝑘),𝑛=0,1,… with the parameters, and the initial conditions 𝑥−𝑘,…,𝑥0 are nonnegative real numbers.
Guo-Mei Tang, Lin-Xia Hu, Gang Ma
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Oscillatory properties for Emden–Fowler type difference equations with oscillating coefficients
Results in Applied MathematicsIn this paper, we give new criteria on the oscillation of the fourth-order Emden–Fowler type delay difference equation with oscillating coefficients of the form ΔWn+rnyn−τβ=0,n≥n0,where Wn=pnΔ3vnα and vn=yn+qnyn−σ.
Yaşar Bolat +2 more
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Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
An explicit finite difference scheme for the Camassa-Holm equation
, 2008 We put forward and analyze an explicit finite difference scheme for the Camassa-Holm shallow water equation that can handle general $H^1$ initial data and thus peakon-antipeakon interactions.
Coclite, Giuseppe Maria +2 more
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On the Linearization of Second-Order Differential and Difference Equations [PDF]
, 2006 В. А. Дородницын
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