Results 81 to 90 of about 380,567 (310)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

On Two Systems of Difference Equations

open access: yesDiscrete Dynamics in Nature and Society, 2010
We give very short and elegant proofs of the main results in the work of Yalcinkaya et al. (2008).
Bratislav Iričanin, Stevo Stević
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Properties of Schwarzian difference equations

open access: yesElectronic Journal of Differential Equations, 2015
We consider the Schwarzian type difference equation $$ \Big[\frac{\Delta^{3}f(z)}{\Delta f(z)}-\frac{3}{2} \Big(\frac{\Delta^{2}f(z)}{\Delta f(z)}\Big)^{2}\Big]^{k}=R(z), $$ where R(z) is a nonconstant rational function.
Shuang-Ting Lan, Zong-Xuan Chen
doaj  

Oscillation of certain partial difference equations

open access: yesDiscrete Dynamics in Nature and Society, 1998
We first obtain sufficiency conditions for the oscillation of all solutions of linear partial difference equation aAm+1,n+1+bAm+1,n+cAm,n+1−dAm,n+Pm,nAm−k,n−1=0.
Sung Kyu Choi, Bing Gen Zhang
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Solutions of the Rational Difference Equations

open access: yesMANAS: Journal of Engineering, 2018
Inthis paper the solutions of the following difference equation is examined, (1) wherethe initial conditions are positive real numbers.
Peil Esengul Kyzy, Dagıstan Şimşek
doaj   +2 more sources

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