Results 81 to 90 of about 2,259,648 (327)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Almost Automorphic Solutions of Difference Equations

Advances in Difference Equations, 2009
We study discrete almost automorphic functions (sequences) defined on the set of integers with values in a Banach space X. Given a bounded linear operator T defined on X and a discrete almost automorphic function f(n), we give criteria for the existence ...
Daniela Araya, Rodrigo Castro, Carlos Lizama   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Generalized β-Hyers-Ulam-Rassias Stability of Impulsive Difference Equations. [PDF]

Comput Intell Neurosci, 2022
Almalki Y, Rahmat G, Ullah A, Shehryar F, Numan M, Ali MU.   +5 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Closed-Form Solutions of a Nonlinear Rational Second-Order Three-Dimensional System of Difference Equations

Mathematics
In this paper, we investigate the behavior of solutions to a nonlinear system of rational difference equations of order two, defined by xn+1=xnyn−1yn(a+bxnyn−1),yn+1=ynzn−1zn(c+dynzn−1),zn+1=znxn−1xn(e+fznxn−1), where n denotes a nonzero integer; the ...
Messaoud Berkal, Taha Radwan, Mehmet Gümüş, Raafat Abo-Zeid, Karim K. Ahmed   +4 more
doaj   +1 more source

Complex adaptive learning cortical neural network systems for solving time-fractional difference equations with bursting and mixed-mode oscillation behaviours. [PDF]

Sci Rep, 2023
Chu YM, Rashid S, Alzahrani T, Alhulayyil H, Alsagri H, Rehman SU.   +5 more
europepmc   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Asymptotic iteration method for solving Hahn difference equations. [PDF]

Adv Differ Equ, 2021
MacQuarrie L, Saad N, Islam MS.
europepmc   +1 more source